{"_id":"MONDO:0800175","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"60719-84-8","chemical_name":"Amrinone","direct_evidence":"therapeutic","mesh_chemical_id":"D000676","pubmed":"1774400","source":"CTD"},{"cas_registry_number":"29122-68-7","chemical_name":"Atenolol","direct_evidence":"marker/mechanism","mesh_chemical_id":"D001262","pubmed":"1764831","source":"CTD"},{"cas_registry_number":"34841-39-9","chemical_name":"Bupropion","direct_evidence":"marker/mechanism","mesh_chemical_id":"D016642","pubmed":"17924251","source":"CTD"},{"chemical_name":"Capecitabine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D000069287","pubmed":"18813211","source":"CTD"},{"chemical_name":"Carbachol","direct_evidence":"marker/mechanism","mesh_chemical_id":"D002217","pubmed":"7110388","source":"CTD"},{"cas_registry_number":"298-46-4","chemical_name":"Carbamazepine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D002220","pubmed":"20129423","source":"CTD"},{"cas_registry_number":"51781-06-7","chemical_name":"Carteolol","direct_evidence":"marker/mechanism","mesh_chemical_id":"D002354","pubmed":"1979694","source":"CTD"},{"chemical_name":"Catecholamines","direct_evidence":"marker/mechanism","mesh_chemical_id":"D002395","pubmed":"15806412","source":"CTD"},{"cas_registry_number":"54-05-7","chemical_name":"Chloroquine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D002738","pubmed":"1774400","source":"CTD"},{"chemical_name":"Cinacalcet","direct_evidence":"marker/mechanism","mesh_chemical_id":"D000069449","pubmed":"17472827","source":"CTD"},{"cas_registry_number":"5786-21-0","chemical_name":"Clozapine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D003024","pubmed":"8664211","source":"CTD"},{"cas_registry_number":"50-36-2","chemical_name":"Cocaine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D003042","pubmed":"20723251","source":"CTD"},{"cas_registry_number":"50-18-0","chemical_name":"Cyclophosphamide","direct_evidence":"marker/mechanism","mesh_chemical_id":"D003520","pubmed":"7707444","source":"CTD"},{"cas_registry_number":"20830-81-3","chemical_name":"Daunorubicin","direct_evidence":"marker/mechanism","mesh_chemical_id":"D003630","pubmed":"3481411","source":"CTD"},{"cas_registry_number":"50-02-2","chemical_name":"Dexamethasone","direct_evidence":"marker/mechanism","mesh_chemical_id":"D003907","pubmed":"11059621","source":"CTD"},{"cas_registry_number":"42399-41-7","chemical_name":"Diltiazem","direct_evidence":"marker/mechanism","mesh_chemical_id":"D004110","pubmed":"1979694","source":"CTD"},{"cas_registry_number":"58-32-2","chemical_name":"Dipyridamole","direct_evidence":"marker/mechanism","mesh_chemical_id":"D004176","pubmed":"15944542","source":"CTD"},{"cas_registry_number":"3737-09-5","chemical_name":"Disopyramide","direct_evidence":"marker/mechanism","mesh_chemical_id":"D004206","pubmed":"7339947","source":"CTD"},{"cas_registry_number":"97-77-8","chemical_name":"Disulfiram","direct_evidence":"marker/mechanism","mesh_chemical_id":"D004221","pubmed":"19390700","source":"CTD"},{"cas_registry_number":"34368-04-2","chemical_name":"Dobutamine","direct_evidence":"therapeutic","mesh_chemical_id":"D004280","pubmed":["16143579","1979694","21037469","9064946"],"source":"CTD"},{"cas_registry_number":"51-61-6","chemical_name":"Dopamine","direct_evidence":"therapeutic","mesh_chemical_id":"D004298","pubmed":["16143579","9064946"],"source":"CTD"},{"cas_registry_number":"51-43-4","chemical_name":"Epinephrine","direct_evidence":"therapeutic","mesh_chemical_id":"D004837","pubmed":"21037469","source":"CTD"},{"cas_registry_number":"54143-55-4","chemical_name":"Flecainide","direct_evidence":"marker/mechanism","mesh_chemical_id":"D005424","pubmed":["11373489","1354292","3141115"],"source":"CTD"},{"cas_registry_number":"51-21-8","chemical_name":"Fluorouracil","direct_evidence":"marker/mechanism","mesh_chemical_id":"D005472","pubmed":["1642435","19499187","2205312","2344152","2351781","2353140","3661619","647321","7954023","8422644","9063536"],"source":"CTD"},{"chemical_name":"Gemcitabine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D000093542","pubmed":"10541971","source":"CTD"},{"chemical_name":"gemeprost","direct_evidence":"marker/mechanism","mesh_chemical_id":"C021182","pubmed":"10904996","source":"CTD"},{"chemical_name":"glimepiride","direct_evidence":"marker/mechanism","mesh_chemical_id":"C057619","pubmed":"8911987","source":"CTD"},{"cas_registry_number":"9007-92-5","chemical_name":"Glucagon","direct_evidence":"therapeutic","mesh_chemical_id":"D005934","pubmed":"3156367","source":"CTD"},{"cas_registry_number":"10238-21-8","chemical_name":"Glyburide","direct_evidence":"marker/mechanism","mesh_chemical_id":"D005905","pubmed":"8911987","source":"CTD"},{"cas_registry_number":"9005-49-6","chemical_name":"Heparin","direct_evidence":"marker/mechanism","mesh_chemical_id":"D006493","pubmed":"5090805","source":"CTD"},{"cas_registry_number":"50-49-7","chemical_name":"Imipramine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D007099","pubmed":"8161395","source":"CTD"},{"cas_registry_number":"7683-59-2","chemical_name":"Isoproterenol","direct_evidence":"therapeutic","mesh_chemical_id":"D007545","pubmed":"3156367","source":"CTD"},{"cas_registry_number":"137-58-6","chemical_name":"Lidocaine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D008012","pubmed":"7154501","source":"CTD"},{"cas_registry_number":"76-99-3","chemical_name":"Methadone","direct_evidence":"marker/mechanism","mesh_chemical_id":"D008691","pubmed":"16997682","source":"CTD"},{"cas_registry_number":"537-46-2","chemical_name":"Methamphetamine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D008694","pubmed":["17404411","1996001"],"source":"CTD"},{"cas_registry_number":"37350-58-6","chemical_name":"Metoprolol","direct_evidence":"marker/mechanism","mesh_chemical_id":"D008790","pubmed":["18566202","3156367","8649751"],"source":"CTD"},{"chemical_name":"Milrinone","direct_evidence":"therapeutic","mesh_chemical_id":"D020105","pubmed":["20628043","9064946"],"source":"CTD"},{"cas_registry_number":"434-22-0","chemical_name":"Nandrolone","direct_evidence":"marker/mechanism","mesh_chemical_id":"D009277","pubmed":"19337937","source":"CTD"},{"cas_registry_number":"15078-28-1","chemical_name":"Nitroprusside","direct_evidence":"therapeutic","mesh_chemical_id":"D009599","pubmed":"3987325","source":"CTD"},{"cas_registry_number":"51-41-2","chemical_name":"Norepinephrine","direct_evidence":"therapeutic","mesh_chemical_id":"D009638","pubmed":"21037469","source":"CTD"},{"cas_registry_number":"35080-11-6","chemical_name":"Prajmaline","direct_evidence":"marker/mechanism","mesh_chemical_id":"D011219","pubmed":"8649751","source":"CTD"},{"cas_registry_number":"51-06-9","chemical_name":"Procainamide","direct_evidence":"marker/mechanism","mesh_chemical_id":"D011342","pubmed":"7154501","source":"CTD"},{"cas_registry_number":"525-66-6","chemical_name":"Propranolol","direct_evidence":"marker/mechanism","mesh_chemical_id":"D011433","pubmed":["10460701","1185021","7154501"],"source":"CTD"},{"cas_registry_number":"616-68-2","chemical_name":"Trimecaine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D014288","pubmed":"7154501","source":"CTD"},{"cas_registry_number":"52-53-9","chemical_name":"Verapamil","direct_evidence":"marker/mechanism","mesh_chemical_id":"D014700","pubmed":["1094900","1354292","1764831","19830220","7154501","9205542"],"source":"CTD"},{"cas_registry_number":"81-81-2","chemical_name":"Warfarin","direct_evidence":"marker/mechanism","mesh_chemical_id":"D014859","pubmed":"5090805","source":"CTD"}],"mesh":"D012770","pathway_related_to_disease":[{"inference_gene_symbol":"EPO","kegg_pathway_id":"hsa04060","pathway_name":"Cytokine-cytokine receptor interaction","source":"CTD"},{"inference_gene_symbol":"EPO","kegg_pathway_id":"hsa04066","pathway_name":"HIF-1 signaling pathway","source":"CTD"},{"inference_gene_symbol":"SOD2","kegg_pathway_id":"hsa04068","pathway_name":"FoxO signaling pathway","source":"CTD"},{"inference_gene_symbol":"SOD2","kegg_pathway_id":"hsa04146","pathway_name":"Peroxisome","source":"CTD"},{"inference_gene_symbol":"EPO","kegg_pathway_id":"hsa04151","pathway_name":"PI3K-Akt signaling pathway","source":"CTD"},{"inference_gene_symbol":"SOD2","kegg_pathway_id":"hsa04211","pathway_name":"Longevity regulating pathway","source":"CTD"},{"inference_gene_symbol":"SOD2","kegg_pathway_id":"hsa04213","pathway_name":"Longevity regulating pathway - multiple species","source":"CTD"},{"inference_gene_symbol":"PLAT","kegg_pathway_id":"hsa04371","pathway_name":"Apelin signaling pathway","source":"CTD"},{"inference_gene_symbol":"PLAT","kegg_pathway_id":"hsa04610","pathway_name":"Complement and coagulation cascades","source":"CTD"},{"inference_gene_symbol":"EPO","kegg_pathway_id":"hsa04630","pathway_name":"Jak-STAT signaling pathway","source":"CTD"},{"inference_gene_symbol":"EPO","kegg_pathway_id":"hsa04640","pathway_name":"Hematopoietic cell lineage","source":"CTD"},{"inference_gene_symbol":"SOD2","kegg_pathway_id":"hsa05016","pathway_name":"Huntington's disease","source":"CTD"},{"inference_gene_symbol":"PLAT","kegg_pathway_id":"hsa05202","pathway_name":"Transcriptional misregulation in cancer","source":"CTD"},{"inference_gene_symbol":"PLAT","kegg_pathway_id":"hsa05418","pathway_name":"Fluid shear stress and atherosclerosis","source":"CTD"},{"inference_gene_symbol":"PLAT","pathway_name":"Hemostasis","react_pathway_id":"R-HSA-109582","source":"CTD"},{"inference_gene_symbol":"EPO","pathway_name":"Regulation of gene expression by Hypoxia-inducible Factor","react_pathway_id":"R-HSA-1234158","source":"CTD"},{"inference_gene_symbol":"EPO","pathway_name":"Regulation of Hypoxia-inducible Factor (HIF) by oxygen","react_pathway_id":"R-HSA-1234174","source":"CTD"},{"inference_gene_symbol":"PLAT","pathway_name":"Signal Transduction","react_pathway_id":"R-HSA-162582","source":"CTD"},{"inference_gene_symbol":"SOD2","pathway_name":"Disease","react_pathway_id":"R-HSA-1643685","source":"CTD"},{"inference_gene_symbol":"PLAT","pathway_name":"Signaling by PDGF","react_pathway_id":"R-HSA-186797","source":"CTD"},{"inference_gene_symbol":"EPO","pathway_name":"Cellular response to hypoxia","react_pathway_id":"R-HSA-2262749","source":"CTD"},{"inference_gene_symbol":["EPO","SOD2"],"pathway_name":"Cellular responses to stress","react_pathway_id":"R-HSA-2262752","source":"CTD"},{"inference_gene_symbol":"SOD2","pathway_name":"Detoxification of Reactive Oxygen Species","react_pathway_id":"R-HSA-3299685","source":"CTD"},{"inference_gene_symbol":"PLAT","pathway_name":"Dissolution of Fibrin Clot","react_pathway_id":"R-HSA-75205","source":"CTD"},{"inference_gene_symbol":"SOD2","pathway_name":"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","react_pathway_id":"R-HSA-8862803","source":"CTD"},{"inference_gene_symbol":"SOD2","pathway_name":"Neurodegenerative Diseases","react_pathway_id":"R-HSA-8863678","source":"CTD"}]},"hpo":{"disease_name":"Cardiogenic shock","orphanet":"97292","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0002615","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0003115","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0005162","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0009805","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000961","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000969","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001635","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001658","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001695","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002094","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0004372","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0006670","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0011675","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0012418","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0012764","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0030830","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0030848","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0030851","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0030876","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0100520","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001289","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001653","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001942","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002151","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002240","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002321","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0003259","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0012251","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001259","orphanet_refs":"orphanet:97292"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001708","orphanet_refs":"orphanet:97292"}]},"mondo":{"ancestors":["MONDO:0700096","MONDO:0000001","MONDO:7770006","MONDO:0005267","MONDO:0004995"],"definition":"A rare, cardiac condition characterized by severely decreased cardiac output, hypoperfusion and end-organ dysfunction, in the presence of adequate intravascular volume. The clinical presentation is variable and may range from subtle hemodynamic alterations to overt cardiovascular collapse. Commonly reported features include dyspnea, crackles, elevated jugular venous pressure, altered mental state, abnormal pulse pressure, oliguria, cold extremities, and increased serum lactate levels. [Orphanet:97292]","label":"cardiogenic shock","mondo":"MONDO:0800175","parents":["MONDO:0005267"],"xrefs":{"gard":["0019362"],"icd10cm":["R57.0"],"icd11":["foundation:1974956233"],"meddra":["10007625"],"medgen":["48650"],"orphanet":["97292"],"umls":["C0036980"]}},"original_id":["MESH:D012770","orphanet:97292"],"umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"preferred":"R57.0"},"icd10am":{"preferred":"R57.0"},"icd10cm":{"preferred":"R57.0"},"icd9cm":{"preferred":"785.51"},"mesh":{"preferred":"D012770"},"nci":{"preferred":"C50482"},"snomed":{"non-preferred":["89138009","158355003","207027002"],"preferred":"89138009"},"umls":"C0036980"}}