{"_id":"MONDO:0019754","_version":1,"ctd":{"chemical_related_to_disease":{"cas_registry_number":"148-82-3","chemical_name":"Melphalan","direct_evidence":"therapeutic","mesh_chemical_id":"D008558","pubmed":"17915620","source":"CTD"},"mesh":"C537372"},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:0111157","DOID:612","DOID:0060704","DOID:4","DOID:7","DOID:2914"],"children":[],"def":"\"A Castleman disease characterized by systemic inflammatory symptoms, polyclonal lymphoproliferation, cytopenias, and multiple organ system dysfunction caused by a cytokine storm often including interleukin-6.\" [url:http\\://www.bloodjournal.org/content/129/12/1646, url:https\\://rarediseases.info.nih.gov/diseases/9644/multicentric-castleman-disease]","descendants":[],"doid":"DOID:0111152","name":"multicentric Castleman disease","parents":["DOID:0111157"],"synonyms":{"exact":["MCD","multicentric giant lymph node hyperplasia","plasmablastic multicentric Castleman disease","PMCD"]},"xrefs":{"gard":"9644","mesh":"C537372","ncit":"C27855","ordo":"93686","snomedct_us_2025_09_01":"1156805003","umls_cui":"C1334815"}},"mondo":{"ancestors":["MONDO:7770009","MONDO:0000001","MONDO:0045024","MONDO:0021669","MONDO:0017341","MONDO:0015157","MONDO:7770010","MONDO:0016537","MONDO:7770008","MONDO:0015564","MONDO:0005070","MONDO:7770006","MONDO:0005046","MONDO:0023370","MONDO:0700096","MONDO:0003847","MONDO:0003778","MONDO:0021674"],"definition":"Multicentric castleman disease (MCD) is an aggressive form of Castleman disease that mostly results from human herpesvirus 8 (HHV8) infection. It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein. [Orphanet:93686]","label":"multicentric Castleman disease","mondo":"MONDO:0019754","parents":["MONDO:0015157","MONDO:0015564"],"seeAlso":{"https":["https://rarediseases.info.nih.gov/diseases/9644/multicentric-castleman-disease"]},"synonym":{"exact":["HHV-8-associated multicentric Castleman disease","Human herpesvirus-8-associated multicentric Castleman disease","MCD","multicentric Angiofollicular lymphoid hyperplasia","multicentric Castleman's disease"],"related":["idiopathic multicentric Castleman's disease","multicentric plasma cell variant of Castleman's disease"]},"xrefs":{"doid":["DOID:0111152"],"gard":["0022310"],"icd11":["foundation:1590444463"],"medgen":["233197"],"ncit":["C27855"],"orphanet":["93686","570438"],"umls":["C1334815"]}},"original_id":"MESH:C537372","umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"non-preferred":"C537372","preferred":"C537372"},"nci":{"non-preferred":"C27855"},"snomed":{"non-preferred":"1156805003"},"umls":"C1334815"}}