{"_id":"MONDO:0019479","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"50-35-1","chemical_name":"Thalidomide","direct_evidence":"therapeutic","mesh_chemical_id":"D013792","pubmed":"17408102","source":"CTD"},{"cas_registry_number":"30516-87-1","chemical_name":"Zidovudine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D015215","pubmed":"10558926","source":"CTD"}],"mesh":"D054747"},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:74","DOID:4","DOID:162","DOID:2531","DOID:7","DOID:0050686","DOID:5621","DOID:14566"],"children":[],"def":"\"A histiocytic and dendritic cell cancer that is characterized by the presence of neoplastic cells with morphologic and immunophenotypic characteristics similar to those seen in mature histiocytes.\" [url:https\\://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520642/]","descendants":[],"doid":"DOID:0080915","name":"histiocytic sarcoma","parents":["DOID:5621"],"synonyms":{},"xrefs":{"icdo":"9755/3","mesh":"D054747","ncit":"C27349"}},"mondo":{"ancestors":["MONDO:0023370","MONDO:0006247","MONDO:0002334","MONDO:0005570","MONDO:0015757","MONDO:0000001","MONDO:0045024","MONDO:7770006","MONDO:0044881","MONDO:7770008","MONDO:0700096","MONDO:0005070"],"definition":"An aggressive malignant neoplasm with a poor response to therapy, usually presenting as stage III/IV disease. It is characterized by the presence of neoplastic cells with morphologic and immunophenotypic characteristics similar to those seen in mature histiocytes. [NCIT:P378]","label":"histiocytic sarcoma","mondo":"MONDO:0019479","parents":["MONDO:0006247"],"synonym":{"exact":["histiocytic sarcoma","sarcoma, histiocytic, malignant"]},"xrefs":{"doid":["DOID:0080915"],"gard":["0019080"],"icd10cm":["C96.A"],"icd11":["foundation:1925254893","foundation:911785965"],"icd9":["171.9"],"icdo":["9755/3"],"medgen":["137793"],"mesh":["D054747"],"ncit":["C27349"],"oncotree":["HS"],"orphanet":["86896"],"sctid":["109988003"],"umls":["C0334663"]}},"umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"non-preferred":"C96.3"},"icd10am":{"non-preferred":["C96.3","M9723/3"]},"icd10cm":{"preferred":"C96.A"},"mesh":{"non-preferred":"D054747","preferred":"D054747"},"nci":{"non-preferred":"C35382","preferred":"C27349"},"snomed":{"non-preferred":["109988003","26640009","188692003","128813000"],"preferred":["109988003","128813000"]},"umls":"C0334663"}}