{"_id":"MONDO:0019454","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"20537-88-6","chemical_name":"Amifostine","direct_evidence":"therapeutic","mesh_chemical_id":"D004999","pubmed":"10688811","source":"CTD"},{"cas_registry_number":"85721-33-1","chemical_name":"Ciprofloxacin","direct_evidence":"therapeutic","mesh_chemical_id":"D002939","pubmed":"10688811","source":"CTD"},{"cas_registry_number":"50-02-2","chemical_name":"Dexamethasone","direct_evidence":"therapeutic","mesh_chemical_id":"D003907","pubmed":"10688811","source":"CTD"},{"cas_registry_number":"59-05-2","chemical_name":"Methotrexate","direct_evidence":"marker/mechanism","mesh_chemical_id":"D008727","pubmed":"16639489","source":"CTD"},{"cas_registry_number":"6493-05-6","chemical_name":"Pentoxifylline","direct_evidence":"therapeutic","mesh_chemical_id":"D010431","pubmed":"10688811","source":"CTD"},{"cas_registry_number":"52-24-4","chemical_name":"Thiotepa","direct_evidence":"marker/mechanism","mesh_chemical_id":"D013852","pubmed":"6776297","source":"CTD"}],"mesh":"D000754"},"hpo":{"disease_name":"Myelodysplastic neoplasm with increased blasts","orphanet":"86839","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0010972","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0012378","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001017","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001945","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001962","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002875","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000573","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001873","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001892","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001974","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002653","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0004808","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0005528","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0005561","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0010741","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0010876","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0012116","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0012136","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0012148","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0012150","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0025065","orphanet_refs":"orphanet:86839"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0031035","orphanet_refs":"orphanet:86839"}]},"mondo":{"ancestors":["MONDO:0000001","MONDO:0045024","MONDO:0005570","MONDO:0002334","MONDO:0018881","MONDO:0044881","MONDO:7770008","MONDO:0005070","MONDO:0021058","MONDO:7770006","MONDO:0023370","MONDO:0700096","MONDO:0015756","MONDO:0002254"],"children":["MONDO:0015040","MONDO:0015041"],"definition":"A myelodysplastic syndrome characterized by the presence of 5-19% myeloblasts in the bone marrow or 2-19% blasts in the peripheral blood. It includes two categories: myelodysplastic syndrome with excess blasts-1 and myelodysplastic syndrome with excess blasts-2. [NCIT:C7506]","descendants":["MONDO:0015040","MONDO:0015041"],"disease_arises_from_structure":{"cl":["CL:0000049"]},"disease_has_feature":{"mondo":["MONDO:0002049"]},"label":"myelodysplastic syndrome with excess blasts","mondo":"MONDO:0019454","parents":["MONDO:0018881","MONDO:0044881"],"synonym":{"exact":["MDS-EB","myelodysplastic syndrome with Excess blasts","RAEB","refractory Anaemia with an Excess of blasts","refractory Anaemia with Excess blasts","refractory Anemia with an Excess of blasts","refractory Anemia with Excess blasts"]},"xrefs":{"efo":["EFO:0003811"],"gard":["0019070"],"icdo":["9983/3"],"meddra":["10038270"],"medgen":["8066"],"mesh":["D000754"],"ncit":["C7506"],"orphanet":["86839"],"sctid":["398623004"],"umls":["C0002894"]}},"original_id":"orphanet:86839","umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"preferred":"D46.2"},"icd10am":{"preferred":["D46.2","M9983/1"]},"icd10cm":{"non-preferred":["D46.20","D46.2"]},"mesh":{"non-preferred":"D000754","preferred":"D000754"},"nci":{"non-preferred":"C7506","preferred":"C7506"},"snomed":{"non-preferred":["109999001","398623004","128847002","189511007","16956001"],"preferred":["398623004","128847002","189511007","16956001"]},"umls":"C0002894"}}