{"_id":"MONDO:0019345","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"69-53-4","chemical_name":"Ampicillin","direct_evidence":"therapeutic","mesh_chemical_id":"D000667","pubmed":"8903184","source":"CTD"},{"cas_registry_number":"389-08-2","chemical_name":"Nalidixic Acid","direct_evidence":"therapeutic","mesh_chemical_id":"D009268","pubmed":"1972527","source":"CTD"}],"mesh":"D004405"},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:0050338","DOID:5295","DOID:104","DOID:4","DOID:7","DOID:0050117","DOID:77","DOID:5353"],"children":[],"def":"\"A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.\" [url:http\\://www.merck.com/mmpe/sec14/ch173/ch173q.html?qt=shigellosis&alt=sh]","descendants":[],"doid":"DOID:12385","name":"shigellosis","parents":["DOID:0050338","DOID:5353"],"synonyms":{"exact":["bacillary dysentery","Shigella boydii infectious disease","Shigella flexneri infectious disease","Shigella gastroenteritis","Shigella sonnei infectious disease"]},"xrefs":{"gard":"4818","icd10":["A03","A03.0","A03.1","A03.2"],"icd9":["004","004.0","004.1","004.2"],"kegg":"05131","mesh":"D004405","ncit":"C157978","snomedct_us_2025_09_01":["111817006","34335000","55760004","66301008"],"umls_cui":["C0013371","C0302358","C0302359","C0302360"]}},"hpo":{"disease_name":"Shigellosis","orphanet":"810","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0001945","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0002027","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0025086","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0032155","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001944","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001974","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002013","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002018","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002039","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0003111","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0012378","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0012702","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0025406","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001531","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001943","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002373","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002590","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002721","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002902","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0025085","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0025615","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0031274","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0100279","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0100282","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0000509","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0000554","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0000979","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001025","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001369","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001396","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001399","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001873","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001919","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001937","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0002090","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0002586","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0003201","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0005575","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0009830","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0012804","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0012819","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0025059","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0031368","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0031864","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0100806","orphanet_refs":"orphanet:810"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0500006","orphanet_refs":"orphanet:810"}]},"mondo":{"ancestors":["MONDO:0004335","MONDO:0005020","MONDO:0000001","MONDO:0000257","MONDO:7770007","MONDO:0001517","MONDO:0020683","MONDO:0000252","MONDO:7770010","MONDO:0005550","MONDO:7770008","MONDO:0024634","MONDO:0002269","MONDO:7770006","MONDO:0005113","MONDO:0700096","MONDO:0001673","MONDO:0021166","MONDO:0000314","MONDO:0000916","MONDO:0043424","MONDO:0000888","MONDO:0020579"],"definition":"Shigellosis is a bacterial infection leading to dysentery and is caused by Shigella, which are small, ubiquitous Gram-negative bacteria belonging to the enterobacteria family. There are four species: S. dysenteriae, S. flexneri, S. boydii and S. sonnei, all of which cause bacillary dysentery and are strictly limited to human hosts. [Orphanet:810]","disease_has_feature":{"hp":["HP:0002027"]},"disease_has_infectious_agent":{"ncbitaxon":["NCBITaxon:621"]},"label":"shigellosis","mondo":"MONDO:0019345","parents":["MONDO:0000314","MONDO:0001517","MONDO:0024634"],"synonym":{"exact":["shigellosis"]},"xrefs":{"doid":["DOID:12385"],"efo":["EFO:0005585"],"gard":["0004818"],"icd10cm":["A03"],"icd10who":["A03"],"icd11":["foundation:2080365623"],"icd9":["004.0","004.2","004.1","004","004.3","004.9"],"meddra":["10017915","10054178"],"medgen":["8513"],"mesh":["D004405"],"ncit":["C157978"],"orphanet":["810"],"sctid":["36188001"],"umls":["C0013371"]}},"original_id":["orphanet:810","UMLS:C0013371","UMLS:C1527298","UMLS:C0302358","UMLS:C0302359","UMLS:C0302360"],"umls":[{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"non-preferred":["A03","A03.9"]},"icd10am":{"non-preferred":["A03","A03.9"]},"icd10cm":{"non-preferred":["A03","A03.9"]},"icd9cm":{"non-preferred":["004.9","004"]},"mesh":{"non-preferred":"D004405","preferred":"D004405"},"nci":{"non-preferred":"C157978"},"snomed":{"non-preferred":["111817006","266175007","187272003","36188001","154272001","186108001"],"preferred":"111817006"},"umls":"C0013371"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10cm":{"preferred":"A03.9"},"mesh":{"preferred":"D004405"},"snomed":{"non-preferred":["266175007","154272001","274081004"],"preferred":["274081004","266175007","36188001","186103005","154272001"]},"umls":"C1527298"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"non-preferred":"A03.0"},"icd10am":{"non-preferred":"A03.0"},"icd10cm":{"non-preferred":"A03.0"},"icd9cm":{"non-preferred":"004.0"},"snomed":{"non-preferred":"66301008","preferred":"66301008"},"umls":"C0302358"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"non-preferred":"A03.1"},"icd10am":{"non-preferred":"A03.1"},"icd10cm":{"non-preferred":"A03.1"},"icd9cm":{"non-preferred":"004.1"},"snomed":{"non-preferred":["186104004","34335000"],"preferred":"34335000"},"umls":"C0302359"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"non-preferred":"A03.2"},"icd10am":{"non-preferred":"A03.2"},"icd10cm":{"non-preferred":"A03.2"},"icd9cm":{"non-preferred":"004.2"},"snomed":{"non-preferred":["55760004","186105003"],"preferred":"55760004"},"umls":"C0302360"}]}