{"_id":"MONDO:0018666","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"15663-27-1","chemical_name":"Cisplatin","direct_evidence":"therapeutic","mesh_chemical_id":"D002945","pubmed":"2206854","source":"CTD"},{"cas_registry_number":"55-18-5","chemical_name":"Diethylnitrosamine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D004052","pubmed":["11560253","11714029","2472233","8242847"],"source":"CTD"},{"cas_registry_number":"51-21-8","chemical_name":"Fluorouracil","direct_evidence":"therapeutic","mesh_chemical_id":"D005472","pubmed":"25178657","source":"CTD"},{"cas_registry_number":"2752-65-0","chemical_name":"gambogic acid","direct_evidence":"therapeutic","mesh_chemical_id":"C052659","pubmed":"24373880","source":"CTD"},{"chemical_name":"IAP protocol","direct_evidence":"therapeutic","mesh_chemical_id":"C056512","pubmed":"11813174","source":"CTD"},{"chemical_name":"JET protocol","direct_evidence":"therapeutic","mesh_chemical_id":"C066308","pubmed":"2206854","source":"CTD"},{"cas_registry_number":"113-45-1","chemical_name":"Methylphenidate","direct_evidence":"marker/mechanism","mesh_chemical_id":"D008774","pubmed":"8545847","source":"CTD"},{"cas_registry_number":"604-75-1","chemical_name":"Oxazepam","direct_evidence":"marker/mechanism","mesh_chemical_id":"D010076","pubmed":"7982536","source":"CTD"},{"cas_registry_number":"50-06-6","chemical_name":"Phenobarbital","direct_evidence":"marker/mechanism","mesh_chemical_id":"D010634","pubmed":["11560253","11714029","2472233","7817132"],"source":"CTD"},{"cas_registry_number":"57-41-0","chemical_name":"Phenytoin","direct_evidence":"marker/mechanism","mesh_chemical_id":"D010672","pubmed":"8242847","source":"CTD"},{"cas_registry_number":"52-53-9","chemical_name":"Verapamil","direct_evidence":"therapeutic","mesh_chemical_id":"D014700","pubmed":"24373880","source":"CTD"}],"mesh":"D018197","pathway_related_to_disease":[{"inference_gene_symbol":"TGFA","kegg_pathway_id":"hsa01521","pathway_name":"EGFR tyrosine kinase inhibitor resistance","source":"CTD"},{"inference_gene_symbol":"PCNA","kegg_pathway_id":"hsa03030","pathway_name":"DNA replication","source":"CTD"},{"inference_gene_symbol":"PCNA","kegg_pathway_id":"hsa03410","pathway_name":"Base excision repair","source":"CTD"},{"inference_gene_symbol":"PCNA","kegg_pathway_id":"hsa03420","pathway_name":"Nucleotide excision repair","source":"CTD"},{"inference_gene_symbol":"PCNA","kegg_pathway_id":"hsa03430","pathway_name":"Mismatch repair","source":"CTD"},{"inference_gene_symbol":"TGFA","kegg_pathway_id":"hsa04012","pathway_name":"ErbB signaling pathway","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa04015","pathway_name":"Rap1 signaling pathway","source":"CTD"},{"inference_gene_symbol":"PCNA","kegg_pathway_id":"hsa04110","pathway_name":"Cell cycle","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa04310","pathway_name":"Wnt signaling pathway","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa04390","pathway_name":"Hippo signaling pathway","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa04510","pathway_name":"Focal adhesion","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa04520","pathway_name":"Adherens junction","source":"CTD"},{"inference_gene_symbol":"PCNA","kegg_pathway_id":"hsa04530","pathway_name":"Tight junction","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa04550","pathway_name":"Signaling pathways regulating pluripotency of stem cells","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa04670","pathway_name":"Leukocyte transendothelial migration","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa04916","pathway_name":"Melanogenesis","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa04919","pathway_name":"Thyroid hormone signaling pathway","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa05100","pathway_name":"Bacterial invasion of epithelial cells","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa05130","pathway_name":"Pathogenic Escherichia coli infection","source":"CTD"},{"inference_gene_symbol":"PCNA","kegg_pathway_id":"hsa05161","pathway_name":"Hepatitis B","source":"CTD"},{"inference_gene_symbol":["CTNNB1","PCNA"],"kegg_pathway_id":"hsa05166","pathway_name":"HTLV-I infection","source":"CTD"},{"inference_gene_symbol":["CTNNB1","TGFA"],"kegg_pathway_id":"hsa05200","pathway_name":"Pathways in cancer","source":"CTD"},{"inference_gene_symbol":["CTNNB1","IGF2"],"kegg_pathway_id":"hsa05205","pathway_name":"Proteoglycans in cancer","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa05210","pathway_name":"Colorectal cancer","source":"CTD"},{"inference_gene_symbol":"TGFA","kegg_pathway_id":"hsa05211","pathway_name":"Renal cell carcinoma","source":"CTD"},{"inference_gene_symbol":"TGFA","kegg_pathway_id":"hsa05212","pathway_name":"Pancreatic cancer","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa05213","pathway_name":"Endometrial cancer","source":"CTD"},{"inference_gene_symbol":"TGFA","kegg_pathway_id":"hsa05214","pathway_name":"Glioma","source":"CTD"},{"inference_gene_symbol":["CTNNB1","TGFA"],"kegg_pathway_id":"hsa05215","pathway_name":"Prostate cancer","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa05216","pathway_name":"Thyroid cancer","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa05217","pathway_name":"Basal cell carcinoma","source":"CTD"},{"inference_gene_symbol":"TGFA","kegg_pathway_id":"hsa05223","pathway_name":"Non-small cell lung cancer","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa05224","pathway_name":"Breast cancer","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa05412","pathway_name":"Arrhythmogenic right ventricular cardiomyopathy (ARVC)","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa05418","pathway_name":"Fluid shear stress and atherosclerosis","source":"CTD"},{"inference_gene_symbol":"PCNA","kegg_pathway_id":"hsa_M00295","pathway_name":"BRCA1-associated genome surveillance complex (BASC)","source":"CTD"},{"inference_gene_symbol":"CTNNB1","kegg_pathway_id":"hsa_M00677","pathway_name":"Wnt signaling","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Apoptosis","react_pathway_id":"R-HSA-109581","source":"CTD"},{"inference_gene_symbol":"IGF2","pathway_name":"Hemostasis","react_pathway_id":"R-HSA-109582","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Translesion synthesis by REV1","react_pathway_id":"R-HSA-110312","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template","react_pathway_id":"R-HSA-110313","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Recognition of DNA damage by PCNA-containing replication complex","react_pathway_id":"R-HSA-110314","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Translesion Synthesis by POLH","react_pathway_id":"R-HSA-110320","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Resolution of AP sites via the multiple-nucleotide patch replacement pathway","react_pathway_id":"R-HSA-110373","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Apoptotic cleavage of cellular proteins","react_pathway_id":"R-HSA-111465","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"E2F mediated regulation of DNA replication","react_pathway_id":"R-HSA-113510","source":"CTD"},{"inference_gene_symbol":"IGF2","pathway_name":"Platelet degranulation","react_pathway_id":"R-HSA-114608","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Developmental Biology","react_pathway_id":"R-HSA-1266738","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Cell-Cell communication","react_pathway_id":"R-HSA-1500931","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"G0 and Early G1","react_pathway_id":"R-HSA-1538133","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Telomere Maintenance","react_pathway_id":"R-HSA-157579","source":"CTD"},{"inference_gene_symbol":["CTNNB1","IGF2"],"pathway_name":"Signal Transduction","react_pathway_id":"R-HSA-162582","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Cell Cycle","react_pathway_id":"R-HSA-1640170","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Disease","react_pathway_id":"R-HSA-1643685","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Innate Immune System","react_pathway_id":"R-HSA-168249","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Immune System","react_pathway_id":"R-HSA-168256","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Polymerase switching on the C-strand of the telomere","react_pathway_id":"R-HSA-174411","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Processive synthesis on the C-strand of the telomere","react_pathway_id":"R-HSA-174414","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Telomere C-strand (Lagging Strand) Synthesis","react_pathway_id":"R-HSA-174417","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Removal of the Flap Intermediate from the C-strand","react_pathway_id":"R-HSA-174437","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Extension of Telomeres","react_pathway_id":"R-HSA-180786","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Cytosolic sensors of pathogen-associated DNA","react_pathway_id":"R-HSA-1834949","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Signaling by VEGF","react_pathway_id":"R-HSA-194138","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Signaling by Rho GTPases","react_pathway_id":"R-HSA-194315","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Degradation of beta-catenin by the destruction complex","react_pathway_id":"R-HSA-195253","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"RHO GTPase Effectors","react_pathway_id":"R-HSA-195258","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Signaling by Wnt","react_pathway_id":"R-HSA-195721","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Beta-catenin phosphorylation cascade","react_pathway_id":"R-HSA-196299","source":"CTD"},{"inference_gene_symbol":"TGFA","pathway_name":"ER to Golgi Anterograde Transport","react_pathway_id":"R-HSA-199977","source":"CTD"},{"inference_gene_symbol":"TGFA","pathway_name":"Membrane Trafficking","react_pathway_id":"R-HSA-199991","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"TCF dependent signaling in response to WNT","react_pathway_id":"R-HSA-201681","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Formation of the beta-catenin:TCF transactivating complex","react_pathway_id":"R-HSA-201722","source":"CTD"},{"inference_gene_symbol":"TGFA","pathway_name":"COPII (Coat Protein 2) Mediated Vesicle Transport","react_pathway_id":"R-HSA-204005","source":"CTD"},{"inference_gene_symbol":["PCNA","TGFA"],"pathway_name":"Generic Transcription Pathway","react_pathway_id":"R-HSA-212436","source":"CTD"},{"inference_gene_symbol":"IGF2","pathway_name":"Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","react_pathway_id":"R-HSA-2404192","source":"CTD"},{"inference_gene_symbol":"IGF2","pathway_name":"IGF1R signaling cascade","react_pathway_id":"R-HSA-2428924","source":"CTD"},{"inference_gene_symbol":"IGF2","pathway_name":"IRS-related events triggered by IGF1R","react_pathway_id":"R-HSA-2428928","source":"CTD"},{"inference_gene_symbol":"IGF2","pathway_name":"SHC-related events triggered by IGF1R","react_pathway_id":"R-HSA-2428933","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Peptide hormone metabolism","react_pathway_id":"R-HSA-2980736","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"SUMOylation","react_pathway_id":"R-HSA-2990846","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"SUMO E3 ligases SUMOylate target proteins","react_pathway_id":"R-HSA-3108232","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production","react_pathway_id":"R-HSA-3134973","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Apoptotic cleavage of cell adhesion  proteins","react_pathway_id":"R-HSA-351906","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Transcriptional Regulation by TP53","react_pathway_id":"R-HSA-3700989","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"CDO in myogenesis","react_pathway_id":"R-HSA-375170","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Deactivation of the beta-catenin transactivating complex","react_pathway_id":"R-HSA-3769402","source":"CTD"},{"inference_gene_symbol":"IGF2","pathway_name":"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)","react_pathway_id":"R-HSA-381426","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)","react_pathway_id":"R-HSA-381771","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Beta-catenin independent WNT signaling","react_pathway_id":"R-HSA-3858494","source":"CTD"},{"inference_gene_symbol":["CTNNB1","IGF2","PCNA","TGFA"],"pathway_name":"Metabolism of proteins","react_pathway_id":"R-HSA-392499","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Incretin synthesis, secretion, and inactivation","react_pathway_id":"R-HSA-400508","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Ca2+ pathway","react_pathway_id":"R-HSA-4086398","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Adherens junctions interactions","react_pathway_id":"R-HSA-418990","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Cell-cell junction organization","react_pathway_id":"R-HSA-421270","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Binding of TCF/LEF:CTNNB1 to target gene promoters","react_pathway_id":"R-HSA-4411364","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"VEGFA-VEGFR2 Pathway","react_pathway_id":"R-HSA-4420097","source":"CTD"},{"inference_gene_symbol":"TGFA","pathway_name":"Asparagine N-linked glycosylation","react_pathway_id":"R-HSA-446203","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Cell junction organization","react_pathway_id":"R-HSA-446728","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Mitotic G1-G1/S phases","react_pathway_id":"R-HSA-453279","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"SUMOylation of DNA replication proteins","react_pathway_id":"R-HSA-4615885","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Disassembly of the destruction complex and recruitment of AXIN to the membrane","react_pathway_id":"R-HSA-4641262","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Signaling by WNT in cancer","react_pathway_id":"R-HSA-4791275","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex","react_pathway_id":"R-HSA-4839743","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"VEGFR2 mediated vascular permeability","react_pathway_id":"R-HSA-5218920","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Myogenesis","react_pathway_id":"R-HSA-525793","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Misspliced GSK3beta mutants stabilize beta-catenin","react_pathway_id":"R-HSA-5339716","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Programmed Cell Death","react_pathway_id":"R-HSA-5357801","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Mismatch Repair","react_pathway_id":"R-HSA-5358508","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)","react_pathway_id":"R-HSA-5358565","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)","react_pathway_id":"R-HSA-5358606","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"S33 mutants of beta-catenin aren't phosphorylated","react_pathway_id":"R-HSA-5358747","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"S37 mutants of beta-catenin aren't phosphorylated","react_pathway_id":"R-HSA-5358749","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"S45 mutants of beta-catenin aren't phosphorylated","react_pathway_id":"R-HSA-5358751","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"T41 mutants of beta-catenin aren't phosphorylated","react_pathway_id":"R-HSA-5358752","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"RHO GTPases activate IQGAPs","react_pathway_id":"R-HSA-5626467","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"PCNA-Dependent Long Patch Base Excision Repair","react_pathway_id":"R-HSA-5651801","source":"CTD"},{"inference_gene_symbol":"TGFA","pathway_name":"Vesicle-mediated transport","react_pathway_id":"R-HSA-5653656","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Translesion synthesis by POLK","react_pathway_id":"R-HSA-5655862","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Translesion synthesis by POLI","react_pathway_id":"R-HSA-5656121","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Termination of translesion DNA synthesis","react_pathway_id":"R-HSA-5656169","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Diseases of signal transduction","react_pathway_id":"R-HSA-5663202","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Infectious disease","react_pathway_id":"R-HSA-5663205","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"HDR through Homologous Recombination (HRR)","react_pathway_id":"R-HSA-5685942","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"DNA Double-Strand Break Repair","react_pathway_id":"R-HSA-5693532","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Homology Directed Repair","react_pathway_id":"R-HSA-5693538","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)","react_pathway_id":"R-HSA-5693567","source":"CTD"},{"inference_gene_symbol":"TGFA","pathway_name":"Cargo concentration in the ER","react_pathway_id":"R-HSA-5694530","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Gap-filling DNA repair synthesis and ligation in GG-NER","react_pathway_id":"R-HSA-5696397","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Nucleotide Excision Repair","react_pathway_id":"R-HSA-5696398","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Global Genome Nucleotide Excision Repair (GG-NER)","react_pathway_id":"R-HSA-5696399","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Dual Incision in GG-NER","react_pathway_id":"R-HSA-5696400","source":"CTD"},{"inference_gene_symbol":["PCNA","TGFA"],"pathway_name":"Post-translational protein modification","react_pathway_id":"R-HSA-597592","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Transcription-Coupled Nucleotide Excision Repair (TC-NER)","react_pathway_id":"R-HSA-6781827","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Dual incision in TC-NER","react_pathway_id":"R-HSA-6782135","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Gap-filling DNA repair synthesis and ligation in TC-NER","react_pathway_id":"R-HSA-6782210","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"TP53 Regulates Transcription of Cell Cycle Genes","react_pathway_id":"R-HSA-6791312","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","react_pathway_id":"R-HSA-6804114","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Polymerase switching","react_pathway_id":"R-HSA-69091","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Leading Strand Synthesis","react_pathway_id":"R-HSA-69109","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Removal of the Flap Intermediate","react_pathway_id":"R-HSA-69166","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Processive synthesis on the lagging strand","react_pathway_id":"R-HSA-69183","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Lagging Strand Synthesis","react_pathway_id":"R-HSA-69186","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"DNA strand elongation","react_pathway_id":"R-HSA-69190","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"G1/S-Specific Transcription","react_pathway_id":"R-HSA-69205","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"G1/S Transition","react_pathway_id":"R-HSA-69206","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Synthesis of DNA","react_pathway_id":"R-HSA-69239","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"S Phase","react_pathway_id":"R-HSA-69242","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Cell Cycle, Mitotic","react_pathway_id":"R-HSA-69278","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"DNA Replication","react_pathway_id":"R-HSA-69306","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Base Excision Repair","react_pathway_id":"R-HSA-73884","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Chromosome Maintenance","react_pathway_id":"R-HSA-73886","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"DNA Damage Bypass","react_pathway_id":"R-HSA-73893","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"DNA Repair","react_pathway_id":"R-HSA-73894","source":"CTD"},{"inference_gene_symbol":"PCNA","pathway_name":"Resolution of Abasic Sites (AP sites)","react_pathway_id":"R-HSA-73933","source":"CTD"},{"inference_gene_symbol":["PCNA","TGFA"],"pathway_name":"Gene Expression","react_pathway_id":"R-HSA-74160","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Apoptotic execution  phase","react_pathway_id":"R-HSA-75153","source":"CTD"},{"inference_gene_symbol":"IGF2","pathway_name":"Platelet activation, signaling and aggregation","react_pathway_id":"R-HSA-76002","source":"CTD"},{"inference_gene_symbol":"IGF2","pathway_name":"Response to elevated platelet cytosolic Ca2+","react_pathway_id":"R-HSA-76005","source":"CTD"},{"inference_gene_symbol":"TGFA","pathway_name":"Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","react_pathway_id":"R-HSA-8864260","source":"CTD"},{"inference_gene_symbol":"TGFA","pathway_name":"TFAP2 (AP-2) family regulates transcription of growth factors and their receptors","react_pathway_id":"R-HSA-8866910","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"Listeria monocytogenes entry into host cells","react_pathway_id":"R-HSA-8876384","source":"CTD"},{"inference_gene_symbol":"CTNNB1","pathway_name":"InlA-mediated entry of Listeria monocytogenes into host cells","react_pathway_id":"R-HSA-8876493","source":"CTD"},{"inference_gene_symbol":"TGFA","pathway_name":"Transport to the Golgi and subsequent modification","react_pathway_id":"R-HSA-948021","source":"CTD"}]},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:3571","DOID:3118","DOID:14566","DOID:170","DOID:0080355","DOID:409","DOID:4","DOID:162","DOID:3119","DOID:7","DOID:77","DOID:0050686"],"children":["DOID:5789","DOID:5798"],"def":"","descendants":["DOID:5789","DOID:5798"],"doid":"DOID:687","name":"hepatoblastoma","parents":["DOID:3571"],"synonyms":{},"xrefs":{"gard":"2657","icd10":"C22.2","icdo":"8970/3","mesh":"D018197","ncit":"C3728","snomedct_us_2025_09_01":"109843000","umls_cui":"C0206624"}},"mondo":{"ancestors":["MONDO:0018531","MONDO:0007256","MONDO:0004335","MONDO:0024477","MONDO:0000001","MONDO:0045024","MONDO:0002691","MONDO:0002516","MONDO:0005154","MONDO:0004992","MONDO:0005564","MONDO:0006181","MONDO:0021223","MONDO:0004970","MONDO:7770008","MONDO:0021069","MONDO:0002515","MONDO:0005070","MONDO:0024276","MONDO:7770006","MONDO:0005151","MONDO:0005626","MONDO:0023370","MONDO:0002082","MONDO:0004993","MONDO:0700096","MONDO:0002514"],"children":["MONDO:0003650","MONDO:0003651"],"definition":"Hepatoblastoma (HB) is a malignant hepatic tumor and is the most common pediatric liver cancer. It is characterized by anorexia, weight loss and an enlarged abdomen. HB is more common in patients with familial adenomatous polyposis (FAP), and can occur in patients with other pre-existing liver conditions. About 5% of HB cases are associated with genetic factors, especially overgrowth syndromes, such as Beckwith-Wiedemann syndrome (BWS) or hemihypertrophy. [Orphanet:449]","descendants":["MONDO:0003651","MONDO:0003650"],"label":"hepatoblastoma","mondo":"MONDO:0018666","parents":["MONDO:0005564","MONDO:0007256"],"synonym":{"exact":["HBL","hepatoblastoma","hepatoblastoma, malignant","paediatric embryonal hepatoma","paediatric hepatoblastoma","pediatric embryonal hepatoma","pediatric hepatoblastoma"]},"xrefs":{"doid":["DOID:687"],"efo":["EFO:1000292"],"gard":["0002657"],"icd10cm":["C22.2"],"icd11":["foundation:1241693063","foundation:1556608523"],"icdo":["8970/3"],"meddra":["10062001"],"medgen":["61644"],"mesh":["D018197"],"nando":["2200046"],"ncit":["C3728"],"oncotree":["LIHB"],"orphanet":["449"],"umls":["C0206624"]}},"umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"preferred":"C22.2"},"icd10am":{"preferred":["C22.2","M8970/3"]},"icd10cm":{"preferred":"C22.2"},"mesh":{"preferred":"D018197"},"nci":{"non-preferred":"C3728","preferred":"C3728"},"snomed":{"non-preferred":["45024009","109843000"],"preferred":["45024009","109843000"]},"umls":"C0206624"}}