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Manifestations of malignant hyperthermia (MH) are precipitated by certain volatile anesthetics (i.e., halothane, isoflurane, sevoflurane, desflurane, enflurane), either alone or in conjunction with a depolarizing muscle relaxant (specifically, succinylcholine).\" [url:http\\://en.wikipedia.org/wiki/Malignant_hyperthermia]","descendants":[],"doid":"DOID:8545","name":"malignant hyperthermia","parents":["DOID:0050736","DOID:66"],"synonyms":{"exact":["anesthesia related hyperthermia","malignant hyperpyrexia due to anesthesia"]},"xrefs":{"gard":"6964","icd10":"T88.3","mesh":"D008305","mim":"PS145600","ordo":"423","snomedct_us_2025_09_01":"111738008","umls_cui":"C0024591"}},"hpo":{"disease_name":"Malignant hyperthermia of anesthesia","orphanet":"423","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001942","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001945","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002047","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002789","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002905","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0003552","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0004755","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0004756","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0011964","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0012416","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0031320","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001722","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001919","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002153","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002913","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0003256","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0006554","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0006682","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0008331","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0008942","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0008978","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0009045","orphanet_refs":"orphanet:423"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:3000005","orphanet_refs":"orphanet:423"}]},"mondo":{"ancestors":["MONDO:7770007","MONDO:0100546","MONDO:0700096","MONDO:7770009","MONDO:0000001","MONDO:0005071","MONDO:7770011","MONDO:0019119","MONDO:7770006","MONDO:0003847","MONDO:0019056","MONDO:0100545","MONDO:7770008"],"definition":"A pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gasses such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, to stresses such as vigorous exercise and heat. [https://orcid.org/0000-0001-5208-3432, Orphanet:423]","disease_has_major_feature":{"hp":["HP:0002047"]},"excluded_subClassOf":{"mondo":["MONDO:0002254"]},"label":"malignant hyperthermia of anesthesia","mondo":"MONDO:0018493","parents":["MONDO:0019119","MONDO:0100546"],"synonym":{"exact":["anaesthesia related hyperthermia","hyperthermia of anaesthesia","hyperthermia of anesthesia","malignant hyperpyrexia","malignant hyperpyrexia due to anaesthesia","malignant hyperthermia","malignant hyperthermia of anesthesia","malignant hyperthermia syndrome"]},"xrefs":{"doid":["DOID:8545"],"gard":["0006964"],"hp":["HP:0002047"],"icd9":["995.86"],"meddra":["10020844"],"medgen":["9867"],"mesh":["D008305"],"ncit":["C84869"],"orphanet":["423"],"sctid":["405501007"],"umls":["C0024591"]}},"original_id":["orphanet:423","UMLS:C5779784","UMLS:C0024591"],"umls":[{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd9cm":{"preferred":"995.86"},"nci":{"non-preferred":"C84869","preferred":"C84869"},"snomed":{"non-preferred":["405501007","248453001"],"preferred":["405501007","248453001"]},"umls":"C5779784"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"non-preferred":"T88.3"},"icd10am":{"non-preferred":"T88.3"},"icd10cm":{"non-preferred":"T88.3"},"mesh":{"non-preferred":"D008305"},"snomed":{"non-preferred":["269435009","157762007","405500008","111738008","213026003"],"preferred":["111738008","405500008","213026003"]},"umls":"C0024591"}]}