{"_id":"MONDO:0018312","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"1397-89-3","chemical_name":"Amphotericin B","direct_evidence":"therapeutic","mesh_chemical_id":"D000666","pubmed":["3487266","6113376","7178410"],"source":"CTD"},{"cas_registry_number":"67-73-2","chemical_name":"Fluocinolone Acetonide","direct_evidence":"marker/mechanism","mesh_chemical_id":"D005446","pubmed":"15767049","source":"CTD"},{"cas_registry_number":"84625-61-6","chemical_name":"Itraconazole","direct_evidence":"therapeutic","mesh_chemical_id":"D017964","pubmed":["11972151","14616112"],"source":"CTD"},{"cas_registry_number":"65277-42-1","chemical_name":"Ketoconazole","direct_evidence":"therapeutic","mesh_chemical_id":"D007654","pubmed":"3487266","source":"CTD"}],"mesh":"D006660"},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:0050292","DOID:4","DOID:0050136","DOID:1564","DOID:0050117"],"children":["DOID:11315","DOID:1759"],"def":"\"A primary systemic mycosis that results in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum or has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains.\" [url:http\\://www.cdc.gov/niosh/hi97146.html]","descendants":["DOID:1759","DOID:11315"],"doid":"DOID:1731","name":"histoplasmosis","parents":["DOID:0050292"],"synonyms":{},"xrefs":{"icd10":"B39","icd9":"115","mesh":["C538362","D006660"],"ncit":["C34977","C77201"],"snomedct_us_2025_09_01":"266218008","umls_cui":["C0019655","C0035288"]}},"mondo":{"ancestors":["MONDO:0002041","MONDO:0700096","MONDO:0005550","MONDO:0000001","MONDO:7770010","MONDO:0000308","MONDO:0000256","MONDO:7770008"],"children":["MONDO:0000981","MONDO:0002099"],"definition":"A disease caused by the fungus Histoplasma capsulatum. It primarily affects the lungs but can also occur as a disseminated disease that affects additional organs. The acute respiratory disease has symptoms similar to those of a cold or flu and it usually resolves without treatment in healthy individuals. The disseminated form is generally fatal if untreated. [NCIT:C77201]","descendants":["MONDO:0001471","MONDO:0002099","MONDO:0001263","MONDO:0000981","MONDO:0001262"],"disease_has_infectious_agent":{"ncbitaxon":["NCBITaxon:5036"]},"label":"histoplasmosis","mondo":"MONDO:0018312","parents":["MONDO:0000308"],"synonym":{"exact":["darling disease","Histoplasma caused disease or disorder","Histoplasma disease or disorder","Histoplasma infectious disease"]},"xrefs":{"doid":["DOID:1731"],"efo":["EFO:0007310"],"gard":["0018692"],"icd10cm":["B39"],"icd10who":["B39"],"icd11":["foundation:1553838370","foundation:1303003466"],"icd9":["115","115.9","115.90","115.99"],"meddra":["10021808","10020141"],"medgen":["42468"],"mesh":["D006660"],"ncit":["C77201"],"orphanet":["390"],"sctid":["12962009"],"umls":["C0019655"]}},"umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"non-preferred":"B39.9","preferred":"B39"},"icd10am":{"non-preferred":"B39.9","preferred":"B39"},"icd10cm":{"non-preferred":"B39.9","preferred":"B39"},"icd9cm":{"non-preferred":"115.9","preferred":"115"},"mesh":{"non-preferred":"D006660","preferred":"D006660"},"nci":{"preferred":"C77201"},"snomed":{"non-preferred":["187055002","187056001","187482000","187063001","12962009"],"preferred":["266218008","154408001","12962009"]},"umls":"C0019655"}}