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syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels. [Orphanet:2905, PMID:23398538]","disease_has_feature":{"mondo":["MONDO:0004959"]},"disease_has_location":{"cl":["CL:0000786"]},"excluded_subClassOf":{"mondo":["MONDO:0002459"]},"label":"POEMS syndrome","mondo":"MONDO:0017364","parents":["MONDO:0004805","MONDO:0015923","MONDO:0018215","MONDO:0700252","MONDO:0700253"],"synonym":{"exact":["Crow-Fukase syndrome","osteosclerotic myeloma","PEP syndrome","POEMS syndrome","polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome","Takatsuki syndrome"],"related":["polyneuropathy organomegaly","polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome"]},"xrefs":{"doid":["DOID:14039"],"efo":["EFO:1001115"],"gard":["0007411"],"icd11":["foundation:1555299114"],"meddra":["10053869"],"medgen":["39276"],"mesh":["D016878"],"nando":["1200033"],"ncit":["C80303"],"nord":["1586"],"orphanet":["2905"],"sctid":["79268002"],"umls":["C0085404"]}},"original_id":"orphanet:2905","umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"non-preferred":"D016878","preferred":"D016878"},"nci":{"non-preferred":"C80303","preferred":"C80303"},"snomed":{"non-preferred":"79268002","preferred":"79268002"},"umls":"C0085404"}}