{"_id":"MONDO:0016566","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"90-89-1","chemical_name":"Diethylcarbamazine","direct_evidence":"therapeutic","mesh_chemical_id":"D004049","pubmed":["1858969","6951321"],"source":"CTD"},{"cas_registry_number":"70288-86-7","chemical_name":"Ivermectin","direct_evidence":"therapeutic","mesh_chemical_id":"D007559","pubmed":"8555762","source":"CTD"}],"mesh":"D008118"},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:37","DOID:0050155","DOID:1398","DOID:4","DOID:16","DOID:1080","DOID:0050117","DOID:863","DOID:5614","DOID:7","DOID:883"],"children":[],"def":"\"A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.\" [url:http\\://en.wikipedia.org/wiki/Loiasis]","descendants":[],"doid":"DOID:13523","name":"loiasis","parents":["DOID:1080","DOID:37","DOID:5614"],"synonyms":{},"xrefs":{"gard":"3283","icd10":"B74.3","icd9":"125.2","mesh":"D008118","ncit":"C34784","snomedct_us_2025_09_01":"44250009","umls_cui":"C0023968"}},"mondo":{"ancestors":["MONDO:0700096","MONDO:0005135","MONDO:0005550","MONDO:0000001","MONDO:7770010","MONDO:0016075","MONDO:0004664","MONDO:7770008"],"definition":"Loiasis is a form of filariasis (see this term), caused by the parasitic worm Loa loa, endemic to the forest and savannah regions of Central and Western Africa. Loiasis may either be asymptomatic or manifest as a large, transient area of localized, non-erythematous subcutaneous edema (Calabar swellings), adult worm migration through the sub-conjunctiva (''African eye worm'') and pruritus. Generalized itching, hives, muscle pains, arthralgias, fatigue, and adult worms visibly migrating under the surface of the skin may be observed. Severe complications such as encephalopathy have been reported in highly infected individuals receiving ivermectin during mass drug administration programs for the control of onchocerciasis and lymphatic filariasis. [Orphanet:2404]","label":"loiasis","mondo":"MONDO:0016566","parents":["MONDO:0016075"],"synonym":{"related":["African eye worm","Loa loa filariasis"]},"xrefs":{"doid":["DOID:13523"],"efo":["EFO:1000729"],"gard":["0003283"],"icd10cm":["B74.3"],"icd11":["foundation:709184369"],"icd9":["125.2"],"meddra":["10024797"],"medgen":["6132"],"mesh":["D008118"],"ncit":["C34784"],"orphanet":["2404"],"sctid":["44250009"],"umls":["C0023968"]}},"umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"preferred":"B74.3"},"icd10am":{"preferred":"B74.3"},"icd10cm":{"non-preferred":"B74.3","preferred":"B74.3"},"icd9cm":{"preferred":"125.2"},"mesh":{"non-preferred":"D008118","preferred":"D008118"},"nci":{"preferred":"C34784"},"snomed":{"non-preferred":"44250009","preferred":"44250009"},"umls":"C0023968"}}