{"_id":"MONDO:0016010","_version":1,"ctd":{"chemical_related_to_disease":{"cas_registry_number":"81-81-2","chemical_name":"Warfarin","direct_evidence":"marker/mechanism","mesh_chemical_id":"D014859","pubmed":["15605910","31238190"],"source":"CTD"},"mesh":"C536683"},"hpo":{"disease_name":"Vitamin K antagonist embryofetopathy","orphanet":"1914","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0000463","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0003196","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0005280","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0008420","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0010655","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000470","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001156","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001249","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001511","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002093","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0009882","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000158","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000238","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000316","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000365","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000453","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000505","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000518","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000520","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000648","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001250","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001252","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002475","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0008056","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0008551","orphanet_refs":"orphanet:1914"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0030680","orphanet_refs":"orphanet:1914"}]},"mondo":{"ancestors":["MONDO:0019755","MONDO:7770007","MONDO:0700096","MONDO:0021147","MONDO:0000001","MONDO:0016677","MONDO:7770006","MONDO:0002254"],"definition":"A teratogenic disorder observed in a newborn or child of a mother who was exposed to warfarin during pregnancy. Manifestations include nasal bridge depression, nasal bones hypoplasia, microcephaly, congenital heart disorders, and brachydactyly. [NCIT:C98906]","label":"vitamin K-antagonist embryofetopathy","mondo":"MONDO:0016010","parents":["MONDO:0002254","MONDO:0016677"],"synonym":{"exact":["di Sala syndrome","fetal Coumadin syndrome","fetal warfarin syndrome","foetal Coumadin syndrome","foetal warfarin syndrome","vitamin K antagonist embryopathy","vitamin K-antagonist embryofetopathy","vitamin K-antagonist embryopathy","warfarin embryofetopathy","warfarin embryopathy"],"related":["congenital warfarin syndrome","coumarin embryopathy","coumarin syndrome","DiSala syndrome","embryofetopathy due to oral anticoagulant therapy","fetal anticoagulant syndrome","foetal anticoagulant syndrome","vitamin K antagonists embryofetopathy","warfarin syndrome"]},"xrefs":{"icd11":["foundation:71579696"],"icd9":["759.89"],"meddra":["10051445"],"medgen":["75570"],"mesh":["C536683"],"ncit":["C98906"],"orphanet":["1914"],"sctid":["38323006"],"umls":["C0265374"]}},"original_id":"orphanet:1914","umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"non-preferred":"Q86.2"},"icd10am":{"non-preferred":"Q86.2"},"icd10cm":{"non-preferred":"Q86.2"},"mesh":{"non-preferred":"C536683","preferred":"C536683"},"nci":{"non-preferred":"C98906"},"snomed":{"non-preferred":["38323006","205790003"]},"umls":"C0265374"}}