{"_id":"MONDO:0015564","_version":1,"ctd":{"chemical_related_to_disease":{"cas_registry_number":"50-35-1","chemical_name":"Thalidomide","direct_evidence":"therapeutic","mesh_chemical_id":"D013792","pubmed":"12701121","source":"CTD"},"mesh":"D005871","pathway_related_to_disease":[{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa01521","pathway_name":"EGFR tyrosine kinase inhibitor resistance","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa01523","pathway_name":"Antifolate resistance","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04060","pathway_name":"Cytokine-cytokine receptor interaction","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04066","pathway_name":"HIF-1 signaling pathway","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04068","pathway_name":"FoxO signaling pathway","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04151","pathway_name":"PI3K-Akt signaling pathway","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04620","pathway_name":"Toll-like receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04621","pathway_name":"NOD-like receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04623","pathway_name":"Cytosolic DNA-sensing pathway","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04630","pathway_name":"Jak-STAT signaling pathway","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04640","pathway_name":"Hematopoietic cell lineage","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04657","pathway_name":"IL-17 signaling pathway","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04659","pathway_name":"Th17 cell differentiation","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04668","pathway_name":"TNF signaling pathway","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04672","pathway_name":"Intestinal immune network for IgA production","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04931","pathway_name":"Insulin resistance","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04932","pathway_name":"Non-alcoholic fatty liver disease (NAFLD)","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa04933","pathway_name":"AGE-RAGE signaling pathway in diabetic complications","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05020","pathway_name":"Prion diseases","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05132","pathway_name":"Salmonella infection","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05133","pathway_name":"Pertussis","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05134","pathway_name":"Legionellosis","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05142","pathway_name":"Chagas disease (American trypanosomiasis)","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05143","pathway_name":"African trypanosomiasis","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05144","pathway_name":"Malaria","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05146","pathway_name":"Amoebiasis","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05152","pathway_name":"Tuberculosis","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05161","pathway_name":"Hepatitis B","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05162","pathway_name":"Measles","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05164","pathway_name":"Influenza A","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05166","pathway_name":"HTLV-I infection","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05168","pathway_name":"Herpes simplex infection","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05200","pathway_name":"Pathways in cancer","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05202","pathway_name":"Transcriptional misregulation in cancer","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05321","pathway_name":"Inflammatory bowel disease (IBD)","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05323","pathway_name":"Rheumatoid arthritis","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05332","pathway_name":"Graft-versus-host disease","source":"CTD"},{"inference_gene_symbol":"IL6","kegg_pathway_id":"hsa05410","pathway_name":"Hypertrophic cardiomyopathy (HCM)","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"Interleukin-6 signaling","react_pathway_id":"R-HSA-1059683","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"MAPK3 (ERK1) activation","react_pathway_id":"R-HSA-110056","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"RAF-independent MAPK1/3 activation","react_pathway_id":"R-HSA-112409","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"MAPK1 (ERK2) activation","react_pathway_id":"R-HSA-112411","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"Cytokine Signaling in Immune system","react_pathway_id":"R-HSA-1280215","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"Signal Transduction","react_pathway_id":"R-HSA-162582","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"Immune System","react_pathway_id":"R-HSA-168256","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"Cellular responses to stress","react_pathway_id":"R-HSA-2262752","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"Senescence-Associated Secretory Phenotype (SASP)","react_pathway_id":"R-HSA-2559582","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"Cellular Senescence","react_pathway_id":"R-HSA-2559583","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"Signaling by Interleukins","react_pathway_id":"R-HSA-449147","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"MAPK family signaling cascades","react_pathway_id":"R-HSA-5683057","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"MAPK1/MAPK3 signaling","react_pathway_id":"R-HSA-5684996","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"Interleukin-6 family signaling","react_pathway_id":"R-HSA-6783589","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"Interleukin-10 signaling","react_pathway_id":"R-HSA-6783783","source":"CTD"},{"inference_gene_symbol":"IL6","pathway_name":"Interleukin-4 and 13 signaling","react_pathway_id":"R-HSA-6785807","source":"CTD"}]},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:612","DOID:0060704","DOID:4","DOID:7","DOID:2914"],"children":["DOID:0111152"],"def":"\"A lymphoproliferative syndrome characterized by one or more enlarged lymph nodes containing cells with hyaline-vascular, plasmacytic, or mixed appearance microscopically.\" [url:https\\://rarediseases.org/rare-diseases/castlemans-disease/]","descendants":["DOID:0111152"],"doid":"DOID:0111157","name":"Castleman disease","parents":["DOID:0060704"],"synonyms":{"exact":["angiofollicular lymph hyperplasia","angiofollicular lymph node hyperplasia","giant lymph node hyperplasia","lymphoid hamartoma"]},"xrefs":{"gard":"12656","icd10":"D47.Z2","mesh":["C536362","D005871"],"ncit":"C3056","ordo":"160","snomedct_us_2025_09_01":"207036003","umls_cui":["C0017531","C2931179"]}},"hpo":{"disease_name":"Castleman disease","orphanet":"160","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0002716","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001824","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001903","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002027","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002729","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0003565","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0011227","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0012378","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0025142","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0030783","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0100721","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000952","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002017","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0003270","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0008940","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0011024","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0012735","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0025066","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0030157","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0031500","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0000083","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0000790","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001723","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001873","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0002094","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0005214","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0006000","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0011974","orphanet_refs":"orphanet:160"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0012050","orphanet_refs":"orphanet:160"}]},"mondo":{"ancestors":["MONDO:0700096","MONDO:7770009","MONDO:0000001","MONDO:0016537","MONDO:0003847","MONDO:0003778","MONDO:7770006","MONDO:0005046","MONDO:7770008"],"children":["MONDO:0019752","MONDO:0019753","MONDO:0019754","MONDO:0035838"],"definition":"Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form. The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms. [Orphanet:160]","descendants":["MONDO:0018702","MONDO:0019752","MONDO:0019753","MONDO:0035838","MONDO:0019754"],"excluded_subClassOf":{"mondo":["MONDO:0015157"]},"label":"Castleman disease","mondo":"MONDO:0015564","parents":["MONDO:0016537"],"synonym":{"exact":["AFLH","angiofollicular ganglionic hyperplasia","angiofollicular lymph hyperplasia","angiofollicular lymph node hyperplasia","angiofollicular lymphoid hyperplasia","Castleman disease","Castleman's disease","Castleman's tumor","Castleman's tumour","giant lymph node hyperplasia","GLNH"],"related":["ALNH"]},"xrefs":{"doid":["DOID:0111157"],"gard":["0012656"],"icd10cm":["D47.Z2"],"icd11":["foundation:1940989685"],"meddra":["10050251"],"medgen":["42211"],"mesh":["D005871"],"ncit":["C3056"],"nord":["898"],"orphanet":["160"],"sctid":["207036003"],"umls":["C0017531"]}},"original_id":["orphanet:160","UMLS:C0017531","UMLS:C2931179"],"umls":[{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10cm":{"non-preferred":"D47.Z2"},"mesh":{"non-preferred":"D005871"},"nci":{"non-preferred":"C3056"},"snomed":{"non-preferred":["367497006","238809002","207036003","781094002","69484003"],"preferred":["207036003","69484003"]},"umls":"C0017531"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"preferred":"C536362"},"umls":"C2931179"}]}