{"_id":"MONDO:0015523","_version":1,"ctd":{"chemical_related_to_disease":{"chemical_name":"Silicones","direct_evidence":"marker/mechanism","mesh_chemical_id":"D012828","pubmed":"15982392","source":"CTD"},"mesh":"D018323","pathway_related_to_disease":[{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa04060","pathway_name":"Cytokine-cytokine receptor interaction","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa04151","pathway_name":"PI3K-Akt signaling pathway","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa04620","pathway_name":"Toll-like receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa04621","pathway_name":"NOD-like receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa04622","pathway_name":"RIG-I-like receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa04623","pathway_name":"Cytosolic DNA-sensing pathway","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa04630","pathway_name":"Jak-STAT signaling pathway","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa04650","pathway_name":"Natural killer cell mediated cytotoxicity","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa05152","pathway_name":"Tuberculosis","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa05160","pathway_name":"Hepatitis C","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa05161","pathway_name":"Hepatitis B","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa05162","pathway_name":"Measles","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa05164","pathway_name":"Influenza A","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa05168","pathway_name":"Herpes simplex infection","source":"CTD"},{"inference_gene_symbol":"IFNA2","kegg_pathway_id":"hsa05320","pathway_name":"Autoimmune thyroid disease","source":"CTD"},{"inference_gene_symbol":"IFNA2","pathway_name":"Hemostasis","react_pathway_id":"R-HSA-109582","source":"CTD"},{"inference_gene_symbol":"IFNA2","pathway_name":"Cytokine Signaling in Immune system","react_pathway_id":"R-HSA-1280215","source":"CTD"},{"inference_gene_symbol":"IFNA2","pathway_name":"Innate Immune System","react_pathway_id":"R-HSA-168249","source":"CTD"},{"inference_gene_symbol":"IFNA2","pathway_name":"Immune System","react_pathway_id":"R-HSA-168256","source":"CTD"},{"inference_gene_symbol":"IFNA2","pathway_name":"RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways","react_pathway_id":"R-HSA-168928","source":"CTD"},{"inference_gene_symbol":"IFNA2","pathway_name":"Interferon alpha/beta signaling","react_pathway_id":"R-HSA-909733","source":"CTD"},{"inference_gene_symbol":"IFNA2","pathway_name":"Regulation of IFNA signaling","react_pathway_id":"R-HSA-912694","source":"CTD"},{"inference_gene_symbol":"IFNA2","pathway_name":"Interferon Signaling","react_pathway_id":"R-HSA-913531","source":"CTD"},{"inference_gene_symbol":"IFNA2","pathway_name":"TRAF6 mediated IRF7 activation","react_pathway_id":"R-HSA-933541","source":"CTD"},{"inference_gene_symbol":"IFNA2","pathway_name":"Factors involved in megakaryocyte development and platelet production","react_pathway_id":"R-HSA-983231","source":"CTD"}]},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:14566","DOID:0080189","DOID:4","DOID:1287","DOID:1115","DOID:175","DOID:0050686","DOID:176","DOID:7","DOID:178","DOID:0050687","DOID:162"],"children":[],"def":"\"A malignant hemangioma characterized by the presence of epithelioid endothelial cells. The neoplastic cells are arranged in cords and nests, which are embedded in a myxoid to hyalinized stroma.\" [url:https\\://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&version=16.12d&ns=NCI_Thesaurus&code=C3800]","descendants":[],"doid":"DOID:0080190","name":"malignant epithelioid hemangioendothelioma","parents":["DOID:0080189"],"synonyms":{},"xrefs":{"ncit":"C3800"}},"mondo":{"ancestors":["MONDO:0000001","MONDO:0005385","MONDO:0045024","MONDO:0002100","MONDO:0004995","MONDO:0004992","MONDO:7770008","MONDO:0021121","MONDO:0005070","MONDO:7770006","MONDO:0023370","MONDO:0024757","MONDO:0700096","MONDO:0021080","MONDO:0024296","MONDO:0002095"],"definition":"A low-grade malignant blood vessel neoplasm. It is characterized by the presence of epithelioid endothelial cells. The neoplastic cells are arranged in cords and nests, which are embedded in a myxoid to hyalinized stroma. [NCIT:C3800]","label":"epithelioid hemangioendothelioma","mondo":"MONDO:0015523","parents":["MONDO:0002095","MONDO:0021121"],"synonym":{"exact":["epithelioid angioendothelioma","epithelioid angiosarcoma","epithelioid hemangioendothelioma","malignant epithelioid hemangioendothelioma"]},"xrefs":{"doid":["DOID:0080190"],"gard":["0020014"],"icdo":["9130/3","9133/1","9133/3"],"medgen":["569676"],"mesh":["D018323"],"ncit":["C3800"],"nord":["124536"],"oncotree":["EHAE"],"orphanet":["157791"],"sctid":["403981003","54124005"],"umls":["C0334538"]}},"original_id":["UMLS:C0206732","UMLS:C0334538"],"umls":[{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10am":{"preferred":"M9133/1"},"mesh":{"preferred":"D018323"},"snomed":{"non-preferred":["189871009","403981003","84290008"],"preferred":["403981003","84290008"]},"umls":"C0206732"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10am":{"preferred":"M9133/3"},"nci":{"non-preferred":"C3800"},"snomed":{"non-preferred":["189872002","54124005"],"preferred":["189872002","54124005"]},"umls":"C0334538"}]}