{"_id":"MONDO:0015306","_version":1,"ctd":{"chemical_related_to_disease":{"chemical_name":"Tetracyclines","direct_evidence":"therapeutic","mesh_chemical_id":"D013754","pubmed":"11089368","source":"CTD"},"mesh":"D005674"},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:104","DOID:0050117","DOID:0050339","DOID:4"],"children":[],"def":"\"A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.\" [url:http\\://en.wikipedia.org/wiki/Fusobacterium_necrophorum, url:https\\://www.merriam-webster.com/medical/necrobacillosis]","descendants":[],"doid":"DOID:11337","name":"Lemierre's syndrome","parents":["DOID:0050339"],"synonyms":{"exact":["human necrobacillosis","Lemierre syndrome","postanginal sepsis"],"related":["acute sore throat"]},"xrefs":{"gard":"6882","icd9":"040.3","mesh":"D005674","snomedct_us_2025_09_01":"52542005","umls_cui":"C0027537"}},"mondo":{"ancestors":["MONDO:0005113","MONDO:0005229","MONDO:0700096","MONDO:0000001","MONDO:1040015","MONDO:7770010","MONDO:0000315","MONDO:0005550","MONDO:7770008"],"definition":"Lemierre syndrome is a rare, potentially lethal, oropharyngeal infectious disease occurring in immunocompetent adolescents and young adults that is mainly due to Fusobacterium necrophorum and that is characterized by septic thrombophlebitis of the internal jugular vein that leads to septic, usually pulmonary, embolism, associated with ENT (ear, nose, and throat) infection that manifests with fever, neck pain, and tonsillopharyngitis. [Orphanet:137839]","disease_has_feature":{"hp":["HP:0001974"]},"label":"Lemierre syndrome","mondo":"MONDO:0015306","parents":["MONDO:0000315","MONDO:0005229"],"synonym":{"exact":["Lemierre postanginal sepsis","Lemierre syndrome","postanginal sepsis secondary to orophyngeal infection","septic phlebitis of the internal jugular vein"],"related":["necrobacillosis","oropharyngeal infection leading to secondary septic thrombophlebitis of the internal jugular vein"]},"xrefs":{"doid":["DOID:11337"],"gard":["0006882"],"icd9":["040.3"],"meddra":["10065552"],"medgen":["6541"],"mesh":["D057831"],"orphanet":["137839"],"sctid":["52542005"],"umls":["C0027537"]}},"original_id":["MESH:D005674","UMLS:C0016879","UMLS:C0027537","UMLS:C0343525"],"umls":[{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"non-preferred":"D005674","preferred":"D005674"},"nci":{"preferred":"C84722"},"umls":"C0016879"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd9cm":{"preferred":"040.3"},"mesh":{"preferred":"D005674"},"snomed":{"non-preferred":"52542005","preferred":"52542005"},"umls":"C0027537"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"non-preferred":"D057831","preferred":"D057831"},"snomed":{"non-preferred":"1231140009","preferred":"1231140009"},"umls":"C0343525"}]}