{"_id":"MONDO:0010434","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"15663-27-1","chemical_name":"Cisplatin","direct_evidence":"therapeutic","mesh_chemical_id":"D002945","pubmed":["2206854","9059068"],"source":"CTD"},{"cas_registry_number":"23214-92-8","chemical_name":"Doxorubicin","direct_evidence":"therapeutic","mesh_chemical_id":"D004317","pubmed":"9059068","source":"CTD"},{"cas_registry_number":"33419-42-0","chemical_name":"Etoposide","direct_evidence":"therapeutic","mesh_chemical_id":"D005047","pubmed":"9059068","source":"CTD"},{"cas_registry_number":"3778-73-2","chemical_name":"Ifosfamide","direct_evidence":"therapeutic","mesh_chemical_id":"D007069","pubmed":["7668875","9059068"],"source":"CTD"},{"chemical_name":"JET protocol","direct_evidence":"therapeutic","mesh_chemical_id":"C066308","pubmed":"2206854","source":"CTD"},{"chemical_name":"pirarubicin","direct_evidence":"therapeutic","mesh_chemical_id":"C027260","pubmed":"7668875","source":"CTD"},{"cas_registry_number":"18883-66-4","chemical_name":"Streptozocin","direct_evidence":"therapeutic","mesh_chemical_id":"D013311","pubmed":"4261143","source":"CTD"},{"chemical_name":"Vincristine","direct_evidence":"therapeutic","mesh_chemical_id":"D014750","pubmed":"7668875","source":"CTD"}],"mesh":"D013584","pathway_related_to_disease":[{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa01521","pathway_name":"EGFR tyrosine kinase inhibitor resistance","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa01522","pathway_name":"Endocrine resistance","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa01524","pathway_name":"Platinum drug resistance","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04064","pathway_name":"NF-kappa B signaling pathway","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04066","pathway_name":"HIF-1 signaling pathway","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04071","pathway_name":"Sphingolipid signaling pathway","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04140","pathway_name":"Autophagy - animal","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04141","pathway_name":"Protein processing in endoplasmic reticulum","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04151","pathway_name":"PI3K-Akt signaling pathway","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04210","pathway_name":"Apoptosis","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04215","pathway_name":"Apoptosis - multiple species","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04261","pathway_name":"Adrenergic signaling in cardiomyocytes","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04340","pathway_name":"Hedgehog signaling pathway","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04510","pathway_name":"Focal adhesion","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04621","pathway_name":"NOD-like receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04630","pathway_name":"Jak-STAT signaling pathway","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04722","pathway_name":"Neurotrophin signaling pathway","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04725","pathway_name":"Cholinergic synapse","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa04933","pathway_name":"AGE-RAGE signaling pathway in diabetic complications","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa05014","pathway_name":"Amyotrophic lateral sclerosis (ALS)","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa05145","pathway_name":"Toxoplasmosis","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa05152","pathway_name":"Tuberculosis","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa05161","pathway_name":"Hepatitis B","source":"CTD"},{"inference_gene_symbol":["BCL2","VIM"],"kegg_pathway_id":"hsa05169","pathway_name":"Epstein-Barr virus infection","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa05200","pathway_name":"Pathways in cancer","source":"CTD"},{"inference_gene_symbol":["SS18","SSX1","SSX2"],"kegg_pathway_id":"hsa05202","pathway_name":"Transcriptional misregulation in cancer","source":"CTD"},{"inference_gene_symbol":["BCL2","VIM"],"kegg_pathway_id":"hsa05206","pathway_name":"MicroRNAs in cancer","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa05210","pathway_name":"Colorectal cancer","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa05215","pathway_name":"Prostate cancer","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa05222","pathway_name":"Small cell lung cancer","source":"CTD"},{"inference_gene_symbol":"BCL2","kegg_pathway_id":"hsa05418","pathway_name":"Fluid shear stress and atherosclerosis","source":"CTD"},{"inference_gene_symbol":["BCL2","VIM"],"pathway_name":"Apoptosis","react_pathway_id":"R-HSA-109581","source":"CTD"},{"inference_gene_symbol":"BCL2","pathway_name":"Intrinsic Pathway for Apoptosis","react_pathway_id":"R-HSA-109606","source":"CTD"},{"inference_gene_symbol":"BCL2","pathway_name":"Activation of BAD and translocation to mitochondria","react_pathway_id":"R-HSA-111447","source":"CTD"},{"inference_gene_symbol":"BCL2","pathway_name":"BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members","react_pathway_id":"R-HSA-111453","source":"CTD"},{"inference_gene_symbol":"VIM","pathway_name":"Apoptotic cleavage of cellular proteins","react_pathway_id":"R-HSA-111465","source":"CTD"},{"inference_gene_symbol":"BCL2","pathway_name":"Activation of BH3-only proteins","react_pathway_id":"R-HSA-114452","source":"CTD"},{"inference_gene_symbol":["BCL2","VIM"],"pathway_name":"Cytokine Signaling in Immune system","react_pathway_id":"R-HSA-1280215","source":"CTD"},{"inference_gene_symbol":"BCL2","pathway_name":"Innate Immune System","react_pathway_id":"R-HSA-168249","source":"CTD"},{"inference_gene_symbol":["BCL2","VIM"],"pathway_name":"Immune System","react_pathway_id":"R-HSA-168256","source":"CTD"},{"inference_gene_symbol":"BCL2","pathway_name":"Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways","react_pathway_id":"R-HSA-168643","source":"CTD"},{"inference_gene_symbol":"VIM","pathway_name":"Caspase-mediated cleavage of cytoskeletal proteins","react_pathway_id":"R-HSA-264870","source":"CTD"},{"inference_gene_symbol":"VIM","pathway_name":"Striated Muscle Contraction","react_pathway_id":"R-HSA-390522","source":"CTD"},{"inference_gene_symbol":"VIM","pathway_name":"Muscle contraction","react_pathway_id":"R-HSA-397014","source":"CTD"},{"inference_gene_symbol":["BCL2","VIM"],"pathway_name":"Signaling by Interleukins","react_pathway_id":"R-HSA-449147","source":"CTD"},{"inference_gene_symbol":["BCL2","VIM"],"pathway_name":"Programmed Cell Death","react_pathway_id":"R-HSA-5357801","source":"CTD"},{"inference_gene_symbol":"BCL2","pathway_name":"Inflammasomes","react_pathway_id":"R-HSA-622312","source":"CTD"},{"inference_gene_symbol":["BCL2","VIM"],"pathway_name":"Interleukin-4 and 13 signaling","react_pathway_id":"R-HSA-6785807","source":"CTD"},{"inference_gene_symbol":"VIM","pathway_name":"Apoptotic execution  phase","react_pathway_id":"R-HSA-75153","source":"CTD"},{"inference_gene_symbol":"BCL2","pathway_name":"The NLRP1 inflammasome","react_pathway_id":"R-HSA-844455","source":"CTD"}]},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:201","DOID:65","DOID:7","DOID:4","DOID:162","DOID:17","DOID:2706","DOID:0060100","DOID:14566","DOID:0050686"],"children":["DOID:5484","DOID:5487","DOID:5488","DOID:5492","DOID:5494","DOID:5495"],"def":"\"A synovium cancer which develops in the synovial membrane of the joints.\" [url:http\\://en.wikipedia.org/wiki/Synovial_sarcoma, url:http\\://www.cancer.gov/dictionary?cdrid=44626]","descendants":["DOID:5494","DOID:5487","DOID:5495","DOID:5492","DOID:5484","DOID:5488"],"doid":"DOID:5485","name":"synovial sarcoma","parents":["DOID:2706"],"synonyms":{},"xrefs":{"gard":"7721","icdo":"9040/3","mesh":"D013584","mim":"300813","ncit":"C3400","snomedct_us_2025_09_01":"63211008","umls_cui":"C0039101"}},"hpo":{"disease_name":"Sarcoma, synovial","inheritance":{"biocuration":{"date":"2014-01-08","name":"HPO:probinson"},"evidence":"IEA","hpo_id":"HP:0001442","hpo_name":"Typified by somatic mosaicism","omim_refs":"OMIM:300813","original_disease_id":"OMIM:300813"},"omim":"300813","phenotype_related_to_disease":{"biocuration":{"date":"2014-01-08","name":"HPO:probinson"},"evidence":"IEA","hpo_id":"HP:0012570","omim_refs":"OMIM:300813","original_disease_id":"OMIM:300813"}},"mondo":{"ancestors":["MONDO:0018078","MONDO:7770009","MONDO:0000001","MONDO:0045024","MONDO:0044334","MONDO:0004992","MONDO:7770008","MONDO:0005089","MONDO:0005070","MONDO:0023370","MONDO:0024637","MONDO:0700096","MONDO:0006424","MONDO:0003847"],"children":["MONDO:0003465","MONDO:0003467","MONDO:0003468","MONDO:0005067","MONDO:0006027"],"definition":"Synovial sarcoma is an aggressive soft tissue sarcoma, occurring most commonly in adolescents and young adults (15 to 40 years), usually localized near the large joints of the extremities but also in the head and neck, mediastinum and viscera (lung, kidney etc), clinically presenting as a deep seated swelling or a painful mass often with an initial indolent course and is characterized by its local invasiveness and a propensity to metastasize. The origin of synovial sarcoma is likely from multipotent mesenchymal cells and not synovium (contrary to its name). [Orphanet:3273]","descendants":["MONDO:0003469","MONDO:0003468","MONDO:0005067","MONDO:0003465","MONDO:0003467","MONDO:0006027","MONDO:0003466"],"excluded_subClassOf":{"mondo":["MONDO:0002403"]},"has_material_basis_in_germline_mutation_in":{"http":["http://identifiers.org/hgnc/11335"]},"label":"synovial sarcoma","mondo":"MONDO:0010434","parents":["MONDO:0003847","MONDO:0018078"],"synonym":{"exact":["sarcoma, synovial, malignant","synovial sarcoma","synovial sarcoma (disease)","Synovialosarcoma"]},"xrefs":{"doid":["DOID:5485"],"efo":["EFO:0001376"],"gard":["0007721"],"hp":["HP:0012570"],"icd9":["171.9"],"icdo":["9040/3"],"meddra":["10042863"],"medgen":["21050"],"mesh":["D013584"],"nando":["2200061"],"ncit":["C3400"],"omim":["300813"],"oncotree":["SYNS"],"orphanet":["3273"],"sctid":["302851001"],"umls":["C0039101"]}},"umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10am":{"preferred":"M9040/3"},"mesh":{"non-preferred":"D013584","preferred":"D013584"},"nci":{"non-preferred":"C3400","preferred":"C3400"},"snomed":{"non-preferred":["302851001","63211008"],"preferred":["302851001","63211008"]},"umls":"C0039101"}}