{"_id":"MONDO:0008797","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"54350-48-0","chemical_name":"Etretinate","direct_evidence":"marker/mechanism","mesh_chemical_id":"D005050","pubmed":"2114463","source":"CTD"},{"cas_registry_number":"302-79-4","chemical_name":"Tretinoin","direct_evidence":"marker/mechanism","mesh_chemical_id":"D014212","pubmed":"2114463","source":"CTD"}],"mesh":"D000848","pathway_related_to_disease":[{"inference_gene_symbol":"MSX1","kegg_pathway_id":"hsa05166","pathway_name":"HTLV-I infection","source":"CTD"},{"inference_gene_symbol":"LTBP3","pathway_name":"Extracellular matrix organization","react_pathway_id":"R-HSA-1474244","source":"CTD"},{"inference_gene_symbol":"LTBP3","pathway_name":"Elastic fibre formation","react_pathway_id":"R-HSA-1566948","source":"CTD"},{"inference_gene_symbol":"LTBP3","pathway_name":"Molecules associated with elastic fibres","react_pathway_id":"R-HSA-2129379","source":"CTD"}]},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:1091","DOID:4","DOID:403","DOID:7","DOID:77"],"children":[],"def":"\"A tooth disease that is characterized by complete absence of permanent teeth.\" [url:https\\://rarediseases.info.nih.gov/diseases/5818/index]","descendants":[],"doid":"DOID:13714","name":"anodontia","parents":["DOID:1091"],"synonyms":{"exact":["Complete absence of teeth","Developmental absence of tooth","Total anodontia of permanent and deciduous teeth"]},"xrefs":{"gard":"5818","icd10":"K00.0","icd9":"520.0","mesh":"D000848","mim":"206780","snomedct_us_2025_09_01":"234951001","umls_cui":"C0399352"}},"hpo":{"disease_name":"Anodontia of permanent dentition","inheritance":{"biocuration":{"date":"2009-02-17","name":"HPO:iea"},"evidence":"IEA","hpo_id":"HP:0000007","hpo_name":"Autosomal recessive inheritance","omim_refs":"OMIM:206780","original_disease_id":"OMIM:206780"},"omim":"206780","phenotype_related_to_disease":{"biocuration":{"date":"2009-02-17","name":"HPO:probinson"},"evidence":"TAS","hpo_id":"HP:0000674","omim_refs":"OMIM:206780","original_disease_id":"OMIM:206780"}},"mondo":{"ancestors":["MONDO:0006858","MONDO:0700096","MONDO:7770009","MONDO:0005172","MONDO:0002081","MONDO:0000001","MONDO:0006999","MONDO:0003847","MONDO:7770006","MONDO:7770008"],"children":["MONDO:0021845","MONDO:0043127","MONDO:0043141"],"definition":"Anodontia is an extreme developmental dental anomaly characterized by the complete absence of all teeth. [Orphanet:99797]","descendants":["MONDO:0043127","MONDO:0043141","MONDO:0021845"],"label":"anodontia","mondo":"MONDO:0008797","parents":["MONDO:0003847","MONDO:0006999"],"synonym":{"exact":["complete absence of teeth","developmental absence of tooth","total anodontia of permanent and deciduous teeth"],"related":["absence of permanent teeth"]},"xrefs":{"doid":["DOID:13714"],"gard":["0005818"],"icd11":["foundation:413433873"],"icd9":["520.0"],"meddra":["10002583"],"medgen":["98313"],"mesh":["D000848"],"omim":["206780"],"orphanet":["99797"],"sctid":["16958000"],"umls":["C0399352"]}},"original_id":["UMLS:C5779669","UMLS:C0399352"],"umls":[{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"preferred":"D000848"},"nci":{"preferred":"C220629"},"umls":"C5779669"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"non-preferred":"K00.0"},"icd10am":{"non-preferred":"K00.0"},"icd10cm":{"non-preferred":"K00.0"},"icd9cm":{"non-preferred":"520.0"},"mesh":{"non-preferred":"D000848"},"snomed":{"non-preferred":["196266006","16958000","26624006","234951001","196269004","196265005"],"preferred":["26624006","234951001"]},"umls":"C0399352"}]}