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Holoprosencephaly is the most commonly identified association, but skeletal, genitourinary and cardiovascular anomalies and situs inversus have been reported.\" [url:https\\://www.ncbi.nlm.nih.gov/pubmed/17438667]","descendants":[],"doid":"DOID:0060341","name":"agnathia-otocephaly complex","parents":["DOID:0080015"],"synonyms":{"exact":["agnathia-holoprosencephaly-situs inversus syndrome","dysgnathia complex agnathia-holoprosencephaly","holoprosencephaly-agnathia","otocephaly"]},"xrefs":{"icd10":"Q18.2","mesh":"C562503","mim":"202650","ordo":"990"}},"hpo":[{"clinical_course":{"biocuration":{"date":"2022-03-12","name":"HPO:probinson"},"evidence":"PCS","freq_denominator":3,"freq_numerator":3,"hpo_id":"HP:0011461","hpo_name":"Fetal onset","numeric_freq":1.0,"original_disease_id":"OMIM:202650","pmid_refs":["PMID:22674740","PMID:22211708","PMID:21294718"]},"disease_name":"Agnathia-Otocephaly 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