{"_id":"MONDO:0008433","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"14439-61-3","chemical_name":"4'-chlorodiazepam","direct_evidence":"therapeutic","mesh_chemical_id":"C028513","pubmed":"11888910","source":"CTD"},{"chemical_name":"4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulfonyldaunorubicin","direct_evidence":"therapeutic","mesh_chemical_id":"C402179","pubmed":"11280756","source":"CTD"},{"chemical_name":"ABT-737","direct_evidence":"therapeutic","mesh_chemical_id":"C501332","pubmed":"19010845","source":"CTD"},{"cas_registry_number":"7440-38-2","chemical_name":"Arsenic","direct_evidence":"marker/mechanism","mesh_chemical_id":"D001151","pubmed":"20049123","source":"CTD"},{"chemical_name":"AVI protocol","direct_evidence":"therapeutic","mesh_chemical_id":"C064082","pubmed":"17166389","source":"CTD"},{"cas_registry_number":"41575-94-4","chemical_name":"Carboplatin","direct_evidence":"therapeutic","mesh_chemical_id":"D016190","pubmed":["11230474","11325490","19262592","20389300","8081707","8741246"],"source":"CTD"},{"cas_registry_number":"15663-27-1","chemical_name":"Cisplatin","direct_evidence":"therapeutic","mesh_chemical_id":"D002945","pubmed":["10815935","15464296","20332701","21519961","21852251","7133078","9890355"],"source":"CTD"},{"cas_registry_number":"50-18-0","chemical_name":"Cyclophosphamide","direct_evidence":"therapeutic","mesh_chemical_id":"D003520","pubmed":["1849442","3568278","6293321"],"source":"CTD"},{"cas_registry_number":"23214-92-8","chemical_name":"Doxorubicin","direct_evidence":"therapeutic","mesh_chemical_id":"D004317","pubmed":["2858016","6293321","7665224"],"source":"CTD"},{"chemical_name":"ECHO protocol","direct_evidence":"therapeutic","mesh_chemical_id":"C035381","pubmed":["6277454","6321685"],"source":"CTD"},{"cas_registry_number":"56420-45-2","chemical_name":"Epirubicin","direct_evidence":"therapeutic","mesh_chemical_id":"D015251","pubmed":["1849442","1964677","8081707"],"source":"CTD"},{"cas_registry_number":"33419-42-0","chemical_name":"Etoposide","direct_evidence":"therapeutic","mesh_chemical_id":"D005047","pubmed":["10815935","11888910","15499612","1849442","20332701","26683772","2858016","3568278","8081707","8098489","8384523","8741246","9890355"],"source":"CTD"},{"chemical_name":"fosbretabulin","direct_evidence":"therapeutic","mesh_chemical_id":"C058728","pubmed":"20389300","source":"CTD"},{"chemical_name":"Gemcitabine","direct_evidence":"therapeutic","mesh_chemical_id":"D000093542","pubmed":["11325490","19262592"],"source":"CTD"},{"chemical_name":"HhAntag691","direct_evidence":"therapeutic","mesh_chemical_id":"C538724","pubmed":"21519961","source":"CTD"},{"cas_registry_number":"3778-73-2","chemical_name":"Ifosfamide","direct_evidence":"therapeutic","mesh_chemical_id":"D007069","pubmed":["10815935","11888910","15499612","2858016","8384523"],"source":"CTD"},{"chemical_name":"Imatinib Mesylate","direct_evidence":"therapeutic","mesh_chemical_id":"D000068877","pubmed":"15499612","source":"CTD"},{"cas_registry_number":"129905-10-8","chemical_name":"inostamycin","direct_evidence":"therapeutic","mesh_chemical_id":"C071861","pubmed":"9818034","source":"CTD"},{"chemical_name":"Irinotecan","direct_evidence":"therapeutic","mesh_chemical_id":"D000077146","pubmed":"21852251","source":"CTD"},{"cas_registry_number":"13010-47-4","chemical_name":"Lomustine","direct_evidence":"therapeutic","mesh_chemical_id":"D008130","pubmed":"6293321","source":"CTD"},{"chemical_name":"ME-344","direct_evidence":"therapeutic","mesh_chemical_id":"C000597890","pubmed":"25411085","source":"CTD"},{"cas_registry_number":"19767-45-4","chemical_name":"Mesna","direct_evidence":"therapeutic","mesh_chemical_id":"D015080","pubmed":"2858016","source":"CTD"},{"cas_registry_number":"59-05-2","chemical_name":"Methotrexate","direct_evidence":"therapeutic","mesh_chemical_id":"D008727","pubmed":"6293321","source":"CTD"},{"cas_registry_number":"364-62-5","chemical_name":"Metoclopramide","direct_evidence":"therapeutic","mesh_chemical_id":"D008787","pubmed":"8384523","source":"CTD"},{"chemical_name":"Nicotine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D009538","pubmed":"20457658","source":"CTD"},{"chemical_name":"Paclitaxel","direct_evidence":"therapeutic","mesh_chemical_id":"D017239","pubmed":["11230474","14760117","20389300","9818034"],"source":"CTD"},{"cas_registry_number":"10043-92-2","chemical_name":"Radon","direct_evidence":"marker/mechanism","mesh_chemical_id":"D011886","pubmed":"22539606","source":"CTD"},{"chemical_name":"shikonin","direct_evidence":"therapeutic","mesh_chemical_id":"C016101","pubmed":"37268198","source":"CTD"},{"cas_registry_number":"50-35-1","chemical_name":"Thalidomide","direct_evidence":"therapeutic","mesh_chemical_id":"D013792","pubmed":"19608997","source":"CTD"},{"cas_registry_number":"123948-87-8","chemical_name":"Topotecan","direct_evidence":"therapeutic","mesh_chemical_id":"D019772","pubmed":["11598410","14760117","15499612","24549232","26683772","9660538"],"source":"CTD"},{"chemical_name":"Vincristine","direct_evidence":"therapeutic","mesh_chemical_id":"D014750","pubmed":["177209","2858016","6293321"],"source":"CTD"},{"cas_registry_number":"53643-48-4","chemical_name":"Vindesine","direct_evidence":"therapeutic","mesh_chemical_id":"D014751","pubmed":"7438123","source":"CTD"},{"chemical_name":"VIP-E protocol","direct_evidence":"therapeutic","mesh_chemical_id":"C091884","pubmed":"9093707","source":"CTD"}],"mesh":"D055752","pathway_related_to_disease":[{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa00230","pathway_name":"Purine metabolism","source":"CTD"},{"inference_gene_symbol":"KMT2A","kegg_pathway_id":"hsa00310","pathway_name":"Lysine degradation","source":"CTD"},{"inference_gene_symbol":"CKB","kegg_pathway_id":"hsa00330","pathway_name":"Arginine and proline metabolism","source":"CTD"},{"inference_gene_symbol":"PTEN","kegg_pathway_id":"hsa00562","pathway_name":"Inositol phosphate metabolism","source":"CTD"},{"inference_gene_symbol":"CKB","kegg_pathway_id":"hsa01100","pathway_name":"Metabolic pathways","source":"CTD"},{"inference_gene_symbol":["EGFR","PTEN"],"kegg_pathway_id":"hsa01521","pathway_name":"EGFR tyrosine kinase inhibitor resistance","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR","RB1","TP53"],"kegg_pathway_id":"hsa01522","pathway_name":"Endocrine resistance","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa01524","pathway_name":"Platinum drug resistance","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","TP53"],"kegg_pathway_id":"hsa04010","pathway_name":"MAPK signaling pathway","source":"CTD"},{"inference_gene_symbol":"EGFR","kegg_pathway_id":"hsa04012","pathway_name":"ErbB signaling pathway","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"kegg_pathway_id":"hsa04014","pathway_name":"Ras signaling pathway","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR","FGFR1","KIT"],"kegg_pathway_id":"hsa04015","pathway_name":"Rap1 signaling pathway","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR"],"kegg_pathway_id":"hsa04020","pathway_name":"Calcium signaling pathway","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04022","pathway_name":"cGMP-PKG signaling pathway","source":"CTD"},{"inference_gene_symbol":["ADCY1","CREBBP","EP300"],"kegg_pathway_id":"hsa04024","pathway_name":"cAMP signaling pathway","source":"CTD"},{"inference_gene_symbol":["CSF3","EGFR","KIT"],"kegg_pathway_id":"hsa04060","pathway_name":"Cytokine-cytokine receptor interaction","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04062","pathway_name":"Chemokine signaling pathway","source":"CTD"},{"inference_gene_symbol":["CREBBP","EGFR","EP300"],"kegg_pathway_id":"hsa04066","pathway_name":"HIF-1 signaling pathway","source":"CTD"},{"inference_gene_symbol":["CREBBP","EGFR","EP300","PTEN"],"kegg_pathway_id":"hsa04068","pathway_name":"FoxO signaling pathway","source":"CTD"},{"inference_gene_symbol":"PTEN","kegg_pathway_id":"hsa04070","pathway_name":"Phosphatidylinositol signaling system","source":"CTD"},{"inference_gene_symbol":["PTEN","TP53"],"kegg_pathway_id":"hsa04071","pathway_name":"Sphingolipid signaling pathway","source":"CTD"},{"inference_gene_symbol":["ADCY1","AVP","EGFR","GRM8","KIT"],"kegg_pathway_id":"hsa04072","pathway_name":"Phospholipase D signaling pathway","source":"CTD"},{"inference_gene_symbol":["GRIK3","GRM8"],"kegg_pathway_id":"hsa04080","pathway_name":"Neuroactive ligand-receptor interaction","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","RB1","TP53"],"kegg_pathway_id":"hsa04110","pathway_name":"Cell cycle","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04114","pathway_name":"Oocyte meiosis","source":"CTD"},{"inference_gene_symbol":["PTEN","TP53"],"kegg_pathway_id":"hsa04115","pathway_name":"p53 signaling pathway","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa04137","pathway_name":"Mitophagy - animal","source":"CTD"},{"inference_gene_symbol":"PTEN","kegg_pathway_id":"hsa04140","pathway_name":"Autophagy - animal","source":"CTD"},{"inference_gene_symbol":["EGFR","KIT"],"kegg_pathway_id":"hsa04144","pathway_name":"Endocytosis","source":"CTD"},{"inference_gene_symbol":"PTEN","kegg_pathway_id":"hsa04150","pathway_name":"mTOR signaling pathway","source":"CTD"},{"inference_gene_symbol":["COL4A2","CSF3","EGFR","FGFR1","KIT","PTEN","TP53"],"kegg_pathway_id":"hsa04151","pathway_name":"PI3K-Akt signaling pathway","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa04210","pathway_name":"Apoptosis","source":"CTD"},{"inference_gene_symbol":["ADCY1","TP53"],"kegg_pathway_id":"hsa04211","pathway_name":"Longevity regulating pathway","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04213","pathway_name":"Longevity regulating pathway - multiple species","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa04216","pathway_name":"Ferroptosis","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04261","pathway_name":"Adrenergic signaling in cardiomyocytes","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04270","pathway_name":"Vascular smooth muscle contraction","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","TP53"],"kegg_pathway_id":"hsa04310","pathway_name":"Wnt signaling pathway","source":"CTD"},{"inference_gene_symbol":"EGFR","kegg_pathway_id":"hsa04320","pathway_name":"Dorso-ventral axis formation","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"kegg_pathway_id":"hsa04330","pathway_name":"Notch signaling pathway","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","ID2"],"kegg_pathway_id":"hsa04350","pathway_name":"TGF-beta signaling pathway","source":"CTD"},{"inference_gene_symbol":["EPHA7","SLIT2"],"kegg_pathway_id":"hsa04360","pathway_name":"Axon guidance","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04371","pathway_name":"Apelin signaling pathway","source":"CTD"},{"inference_gene_symbol":["ID2","SOX2"],"kegg_pathway_id":"hsa04390","pathway_name":"Hippo signaling pathway","source":"CTD"},{"inference_gene_symbol":["COL4A2","EGFR","PTEN"],"kegg_pathway_id":"hsa04510","pathway_name":"Focal adhesion","source":"CTD"},{"inference_gene_symbol":"COL4A2","kegg_pathway_id":"hsa04512","pathway_name":"ECM-receptor interaction","source":"CTD"},{"inference_gene_symbol":"CNTNAP2","kegg_pathway_id":"hsa04514","pathway_name":"Cell adhesion molecules (CAMs)","source":"CTD"},{"inference_gene_symbol":["CREBBP","EGFR","EP300","FGFR1"],"kegg_pathway_id":"hsa04520","pathway_name":"Adherens junction","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR"],"kegg_pathway_id":"hsa04540","pathway_name":"Gap junction","source":"CTD"},{"inference_gene_symbol":["FGFR1","ID2","SOX2"],"kegg_pathway_id":"hsa04550","pathway_name":"Signaling pathways regulating pluripotency of stem cells","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04611","pathway_name":"Platelet activation","source":"CTD"},{"inference_gene_symbol":["CREBBP","CSF3","EP300"],"kegg_pathway_id":"hsa04630","pathway_name":"Jak-STAT signaling pathway","source":"CTD"},{"inference_gene_symbol":["CSF3","KIT"],"kegg_pathway_id":"hsa04640","pathway_name":"Hematopoietic cell lineage","source":"CTD"},{"inference_gene_symbol":"CSF3","kegg_pathway_id":"hsa04657","pathway_name":"IL-17 signaling pathway","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04713","pathway_name":"Circadian entrainment","source":"CTD"},{"inference_gene_symbol":["ADCY1","CREBBP","EP300"],"kegg_pathway_id":"hsa04720","pathway_name":"Long-term potentiation","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa04722","pathway_name":"Neurotrophin signaling pathway","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04723","pathway_name":"Retrograde endocannabinoid signaling","source":"CTD"},{"inference_gene_symbol":["ADCY1","GRIK3","GRM8"],"kegg_pathway_id":"hsa04724","pathway_name":"Glutamatergic synapse","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04725","pathway_name":"Cholinergic synapse","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04727","pathway_name":"GABAergic synapse","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04750","pathway_name":"Inflammatory mediator regulation of TRP channels","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1"],"kegg_pathway_id":"hsa04810","pathway_name":"Regulation of actin cytoskeleton","source":"CTD"},{"inference_gene_symbol":["ADCY1","RIMS2"],"kegg_pathway_id":"hsa04911","pathway_name":"Insulin secretion","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR"],"kegg_pathway_id":"hsa04912","pathway_name":"GnRH signaling pathway","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04913","pathway_name":"Ovarian steroidogenesis","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04914","pathway_name":"Progesterone-mediated oocyte maturation","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR"],"kegg_pathway_id":"hsa04915","pathway_name":"Estrogen signaling pathway","source":"CTD"},{"inference_gene_symbol":["ADCY1","CREBBP","EP300","KIT"],"kegg_pathway_id":"hsa04916","pathway_name":"Melanogenesis","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04918","pathway_name":"Thyroid hormone synthesis","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","TP53"],"kegg_pathway_id":"hsa04919","pathway_name":"Thyroid hormone signaling pathway","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR"],"kegg_pathway_id":"hsa04921","pathway_name":"Oxytocin signaling pathway","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"kegg_pathway_id":"hsa04922","pathway_name":"Glucagon signaling pathway","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04923","pathway_name":"Regulation of lipolysis in adipocytes","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04925","pathway_name":"Aldosterone synthesis and secretion","source":"CTD"},{"inference_gene_symbol":"PTEN","kegg_pathway_id":"hsa04931","pathway_name":"Insulin resistance","source":"CTD"},{"inference_gene_symbol":"COL4A2","kegg_pathway_id":"hsa04933","pathway_name":"AGE-RAGE signaling pathway in diabetic complications","source":"CTD"},{"inference_gene_symbol":"AVP","kegg_pathway_id":"hsa04962","pathway_name":"Vasopressin-regulated water reabsorption","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04970","pathway_name":"Salivary secretion","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04971","pathway_name":"Gastric acid secretion","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04972","pathway_name":"Pancreatic secretion","source":"CTD"},{"inference_gene_symbol":["COL22A1","COL4A2"],"kegg_pathway_id":"hsa04974","pathway_name":"Protein digestion and absorption","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa04976","pathway_name":"Bile secretion","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05014","pathway_name":"Amyotrophic lateral sclerosis (ALS)","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","TP53"],"kegg_pathway_id":"hsa05016","pathway_name":"Huntington's disease","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa05032","pathway_name":"Morphine addiction","source":"CTD"},{"inference_gene_symbol":"EGFR","kegg_pathway_id":"hsa05120","pathway_name":"Epithelial cell signaling in Helicobacter pylori infection","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa05142","pathway_name":"Chagas disease (American trypanosomiasis)","source":"CTD"},{"inference_gene_symbol":"CSF3","kegg_pathway_id":"hsa05144","pathway_name":"Malaria","source":"CTD"},{"inference_gene_symbol":["ADCY1","COL4A2"],"kegg_pathway_id":"hsa05146","pathway_name":"Amoebiasis","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"kegg_pathway_id":"hsa05152","pathway_name":"Tuberculosis","source":"CTD"},{"inference_gene_symbol":["EGFR","TP53"],"kegg_pathway_id":"hsa05160","pathway_name":"Hepatitis C","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","PTEN","RB1","TP53"],"kegg_pathway_id":"hsa05161","pathway_name":"Hepatitis B","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05162","pathway_name":"Measles","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"kegg_pathway_id":"hsa05164","pathway_name":"Influenza A","source":"CTD"},{"inference_gene_symbol":["ADCY1","CREBBP","EP300","RB1","TP53"],"kegg_pathway_id":"hsa05166","pathway_name":"HTLV-I infection","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","TP53"],"kegg_pathway_id":"hsa05168","pathway_name":"Herpes simplex infection","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","RB1","TP53"],"kegg_pathway_id":"hsa05169","pathway_name":"Epstein-Barr virus infection","source":"CTD"},{"inference_gene_symbol":["ADCY1","COL4A2","CREBBP","EGFR","EP300","FGFR1","KIT","PTEN","RB1","RUNX1T1","TP53"],"kegg_pathway_id":"hsa05200","pathway_name":"Pathways in cancer","source":"CTD"},{"inference_gene_symbol":["ID2","KMT2A","RUNX1T1","TP53"],"kegg_pathway_id":"hsa05202","pathway_name":"Transcriptional misregulation in cancer","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","RB1","TP53"],"kegg_pathway_id":"hsa05203","pathway_name":"Viral carcinogenesis","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","TP53"],"kegg_pathway_id":"hsa05205","pathway_name":"Proteoglycans in cancer","source":"CTD"},{"inference_gene_symbol":["CREBBP","EGFR","EP300","PTEN","TP53"],"kegg_pathway_id":"hsa05206","pathway_name":"MicroRNAs in cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05210","pathway_name":"Colorectal cancer","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"kegg_pathway_id":"hsa05211","pathway_name":"Renal cell carcinoma","source":"CTD"},{"inference_gene_symbol":["EGFR","RB1","TP53"],"kegg_pathway_id":"hsa05212","pathway_name":"Pancreatic cancer","source":"CTD"},{"inference_gene_symbol":["EGFR","PTEN","TP53"],"kegg_pathway_id":"hsa05213","pathway_name":"Endometrial cancer","source":"CTD"},{"inference_gene_symbol":["EGFR","PTEN","RB1","TP53"],"kegg_pathway_id":"hsa05214","pathway_name":"Glioma","source":"CTD"},{"inference_gene_symbol":["CREBBP","EGFR","EP300","FGFR1","PTEN","RB1","TP53"],"kegg_pathway_id":"hsa05215","pathway_name":"Prostate cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05216","pathway_name":"Thyroid cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05217","pathway_name":"Basal cell carcinoma","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","PTEN","RB1","TP53"],"kegg_pathway_id":"hsa05218","pathway_name":"Melanoma","source":"CTD"},{"inference_gene_symbol":["EGFR","RB1","TP53"],"kegg_pathway_id":"hsa05219","pathway_name":"Bladder cancer","source":"CTD"},{"inference_gene_symbol":["RB1","TP53"],"kegg_pathway_id":"hsa05220","pathway_name":"Chronic myeloid leukemia","source":"CTD"},{"inference_gene_symbol":["KIT","RUNX1T1"],"kegg_pathway_id":"hsa05221","pathway_name":"Acute myeloid leukemia","source":"CTD"},{"inference_gene_symbol":["COL4A2","PTEN","RB1","TP53"],"kegg_pathway_id":"hsa05222","pathway_name":"Small cell lung cancer","source":"CTD"},{"inference_gene_symbol":["EGFR","RB1","TP53"],"kegg_pathway_id":"hsa05223","pathway_name":"Non-small cell lung cancer","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT","PTEN","RB1","TP53"],"kegg_pathway_id":"hsa05224","pathway_name":"Breast cancer","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT","PTEN","TP53"],"kegg_pathway_id":"hsa05230","pathway_name":"Central carbon metabolism in cancer","source":"CTD"},{"inference_gene_symbol":"EGFR","kegg_pathway_id":"hsa05231","pathway_name":"Choline metabolism in cancer","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa05414","pathway_name":"Dilated cardiomyopathy","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05418","pathway_name":"Fluid shear stress and atherosclerosis","source":"CTD"},{"inference_gene_symbol":"CKB","kegg_pathway_id":"hsa_M00047","pathway_name":"Creatine pathway","source":"CTD"},{"inference_gene_symbol":"RB1","kegg_pathway_id":"hsa_M00692","pathway_name":"Cell cycle - G1/S transition","source":"CTD"},{"inference_gene_symbol":"ADCY1","kegg_pathway_id":"hsa_M00695","pathway_name":"cAMP signaling","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Apoptosis","react_pathway_id":"R-HSA-109581","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","KIF21A","TP53"],"pathway_name":"Hemostasis","react_pathway_id":"R-HSA-109582","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Intrinsic Pathway for Apoptosis","react_pathway_id":"R-HSA-109606","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"PI3K Cascade","react_pathway_id":"R-HSA-109704","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Activation of NOXA and translocation to mitochondria","react_pathway_id":"R-HSA-111448","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Opioid Signalling","react_pathway_id":"R-HSA-111885","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"PKA-mediated phosphorylation of CREB","react_pathway_id":"R-HSA-111931","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Calmodulin induced events","react_pathway_id":"R-HSA-111933","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Ca-dependent events","react_pathway_id":"R-HSA-111996","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"CaM pathway","react_pathway_id":"R-HSA-111997","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"G-protein mediated events","react_pathway_id":"R-HSA-112040","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"PLC beta mediated events","react_pathway_id":"R-HSA-112043","source":"CTD"},{"inference_gene_symbol":["ADCY1","GRIK3"],"pathway_name":"Neurotransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell","react_pathway_id":"R-HSA-112314","source":"CTD"},{"inference_gene_symbol":["ADCY1","GRIK3"],"pathway_name":"Transmission across Chemical Synapses","react_pathway_id":"R-HSA-112315","source":"CTD"},{"inference_gene_symbol":["ADCY1","GRIK3"],"pathway_name":"Neuronal System","react_pathway_id":"R-HSA-112316","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"IRS-mediated signalling","react_pathway_id":"R-HSA-112399","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"SOS-mediated signalling","react_pathway_id":"R-HSA-112412","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Inhibition of replication initiation of damaged DNA by RB1/E2F1","react_pathway_id":"R-HSA-113501","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"E2F mediated regulation of DNA replication","react_pathway_id":"R-HSA-113510","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Activation of BH3-only proteins","react_pathway_id":"R-HSA-114452","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"Downstream signaling events of B Cell Receptor (BCR)","react_pathway_id":"R-HSA-1168372","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"Signaling by FGFR in disease","react_pathway_id":"R-HSA-1226099","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"Signaling by ERBB2","react_pathway_id":"R-HSA-1227986","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Regulation of gene expression by Hypoxia-inducible Factor","react_pathway_id":"R-HSA-1234158","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Regulation of Hypoxia-inducible Factor (HIF) by oxygen","react_pathway_id":"R-HSA-1234174","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants","react_pathway_id":"R-HSA-1236382","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"Signaling by ERBB4","react_pathway_id":"R-HSA-1236394","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"SHC1 events in ERBB2 signaling","react_pathway_id":"R-HSA-1250196","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"PLCG1 events in ERBB2 signaling","react_pathway_id":"R-HSA-1251932","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"PIP3 activates AKT signaling","react_pathway_id":"R-HSA-1257604","source":"CTD"},{"inference_gene_symbol":"SMARCA4","pathway_name":"Interleukin-7 signaling","react_pathway_id":"R-HSA-1266695","source":"CTD"},{"inference_gene_symbol":["COL4A2","CREBBP","EGFR","EP300","EPHA7","FGFR1","INSM1","KIT","SLIT2","SOX2"],"pathway_name":"Developmental Biology","react_pathway_id":"R-HSA-1266738","source":"CTD"},{"inference_gene_symbol":["CSF3","EGFR","FGFR1","KIT","SMARCA4","SOX2","TP53"],"pathway_name":"Cytokine Signaling in Immune system","react_pathway_id":"R-HSA-1280215","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"Adaptive Immune System","react_pathway_id":"R-HSA-1280218","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"RORA activates gene expression","react_pathway_id":"R-HSA-1368082","source":"CTD"},{"inference_gene_symbol":["AVP","CREBBP","EP300"],"pathway_name":"BMAL1:CLOCK,NPAS2 activates circadian gene expression","react_pathway_id":"R-HSA-1368108","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Activation of PUMA and translocation to mitochondria","react_pathway_id":"R-HSA-139915","source":"CTD"},{"inference_gene_symbol":["ADCY1","CKB","CREBBP","EP300","PTEN"],"pathway_name":"Metabolism","react_pathway_id":"R-HSA-1430728","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"Signaling by SCF-KIT","react_pathway_id":"R-HSA-1433557","source":"CTD"},{"inference_gene_symbol":"KIT","pathway_name":"Regulation of KIT signaling","react_pathway_id":"R-HSA-1433559","source":"CTD"},{"inference_gene_symbol":["COL22A1","COL4A2"],"pathway_name":"Extracellular matrix organization","react_pathway_id":"R-HSA-1474244","source":"CTD"},{"inference_gene_symbol":["COL22A1","COL4A2"],"pathway_name":"Collagen formation","react_pathway_id":"R-HSA-1474290","source":"CTD"},{"inference_gene_symbol":"PTEN","pathway_name":"Inositol phosphate metabolism","react_pathway_id":"R-HSA-1483249","source":"CTD"},{"inference_gene_symbol":"PTEN","pathway_name":"PI Metabolism","react_pathway_id":"R-HSA-1483255","source":"CTD"},{"inference_gene_symbol":"PTEN","pathway_name":"Phospholipid metabolism","react_pathway_id":"R-HSA-1483257","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"DAG and IP3 signaling","react_pathway_id":"R-HSA-1489509","source":"CTD"},{"inference_gene_symbol":"EP300","pathway_name":"Polo-like kinase mediated events","react_pathway_id":"R-HSA-156711","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","TP53"],"pathway_name":"Signaling by NOTCH","react_pathway_id":"R-HSA-157118","source":"CTD"},{"inference_gene_symbol":"CREBBP","pathway_name":"Mitochondrial biogenesis","react_pathway_id":"R-HSA-1592230","source":"CTD"},{"inference_gene_symbol":["ADCY1","AVP","COL4A2","CREBBP","EGFR","EP300","FGFR1","GRM8","KIT","PTEN","SMARCA4","SOX2","TP53"],"pathway_name":"Signal Transduction","react_pathway_id":"R-HSA-162582","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Glucagon signaling in metabolic regulation","react_pathway_id":"R-HSA-163359","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"PKA activation","react_pathway_id":"R-HSA-163615","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Integration of energy metabolism","react_pathway_id":"R-HSA-163685","source":"CTD"},{"inference_gene_symbol":["EP300","RB1","TP53"],"pathway_name":"Cell Cycle","react_pathway_id":"R-HSA-1640170","source":"CTD"},{"inference_gene_symbol":["AVP","CREBBP","EGFR","EP300","FGFR1","KIT"],"pathway_name":"Disease","react_pathway_id":"R-HSA-1643685","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"Signaling by EGFR in Cancer","react_pathway_id":"R-HSA-1643713","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"PKA activation in glucagon signalling","react_pathway_id":"R-HSA-164378","source":"CTD"},{"inference_gene_symbol":["COL22A1","COL4A2"],"pathway_name":"Collagen biosynthesis and modifying enzymes","react_pathway_id":"R-HSA-1650814","source":"CTD"},{"inference_gene_symbol":"CREBBP","pathway_name":"Regulation of cholesterol biosynthesis by SREBP (SREBF)","react_pathway_id":"R-HSA-1655829","source":"CTD"},{"inference_gene_symbol":"PTEN","pathway_name":"Synthesis of PIPs at the plasma membrane","react_pathway_id":"R-HSA-1660499","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"Signalling by NGF","react_pathway_id":"R-HSA-166520","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"PLC-gamma1 signalling","react_pathway_id":"R-HSA-167021","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Signalling to RAS","react_pathway_id":"R-HSA-167044","source":"CTD"},{"inference_gene_symbol":["ADCY1","CREBBP","EGFR","EP300","FGFR1","KIT","PTEN","TP53"],"pathway_name":"Innate Immune System","react_pathway_id":"R-HSA-168249","source":"CTD"},{"inference_gene_symbol":["ADCY1","CREBBP","CSF3","EGFR","EP300","FGFR1","KIT","PTEN","SMARCA4","SOX2","TP53"],"pathway_name":"Immune System","react_pathway_id":"R-HSA-168256","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways","react_pathway_id":"R-HSA-168928","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Prolonged ERK activation events","react_pathway_id":"R-HSA-169893","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Adenylate cyclase activating pathway","react_pathway_id":"R-HSA-170660","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Adenylate cyclase inhibitory pathway","react_pathway_id":"R-HSA-170670","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Frs2-mediated activation","react_pathway_id":"R-HSA-170968","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"ARMS-mediated activation","react_pathway_id":"R-HSA-170984","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"Signaling by EGFR","react_pathway_id":"R-HSA-177929","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"GRB2 events in EGFR signaling","react_pathway_id":"R-HSA-179812","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"GAB1 signalosome","react_pathway_id":"R-HSA-180292","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"SHC1 events in EGFR signaling","react_pathway_id":"R-HSA-180336","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"EGFR downregulation","react_pathway_id":"R-HSA-182971","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Cytosolic sensors of pathogen-associated DNA","react_pathway_id":"R-HSA-1834949","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"Signaling by FGFR1 amplification mutants","react_pathway_id":"R-HSA-1839120","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"Signaling by activated point mutants of FGFR1","react_pathway_id":"R-HSA-1839122","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"FGFR1 mutant receptor activation","react_pathway_id":"R-HSA-1839124","source":"CTD"},{"inference_gene_symbol":"CREBBP","pathway_name":"Organelle biogenesis and maintenance","react_pathway_id":"R-HSA-1852241","source":"CTD"},{"inference_gene_symbol":"PTEN","pathway_name":"Synthesis of IP3 and IP4 in the cytosol","react_pathway_id":"R-HSA-1855204","source":"CTD"},{"inference_gene_symbol":"INSM1","pathway_name":"Regulation of beta-cell development","react_pathway_id":"R-HSA-186712","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"Downstream signal transduction","react_pathway_id":"R-HSA-186763","source":"CTD"},{"inference_gene_symbol":["ADCY1","COL4A2","EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"Signaling by PDGF","react_pathway_id":"R-HSA-186797","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"NGF signalling via TRKA from the plasma membrane","react_pathway_id":"R-HSA-187037","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Signalling to ERKs","react_pathway_id":"R-HSA-187687","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Signalling to p38 via RIT and RIN","react_pathway_id":"R-HSA-187706","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"Signaling by FGFR","react_pathway_id":"R-HSA-190236","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"FGFR1 ligand binding and activation","react_pathway_id":"R-HSA-190242","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"FGFR1b ligand binding and activation","react_pathway_id":"R-HSA-190370","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"FGFR1c ligand binding and activation","react_pathway_id":"R-HSA-190373","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"FGFR1c and Klotho ligand binding and activation","react_pathway_id":"R-HSA-190374","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","TP53"],"pathway_name":"Pre-NOTCH Transcription and Translation","react_pathway_id":"R-HSA-1912408","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","TP53"],"pathway_name":"Pre-NOTCH Expression and Processing","react_pathway_id":"R-HSA-1912422","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Signaling by VEGF","react_pathway_id":"R-HSA-194138","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","SMARCA4","SOX2"],"pathway_name":"Signaling by Wnt","react_pathway_id":"R-HSA-195721","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"GRB2 events in ERBB2 signaling","react_pathway_id":"R-HSA-1963640","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"PI3K events in ERBB2 signaling","react_pathway_id":"R-HSA-1963642","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Signaling by NOTCH1","react_pathway_id":"R-HSA-1980143","source":"CTD"},{"inference_gene_symbol":"EP300","pathway_name":"Signaling by NOTCH2","react_pathway_id":"R-HSA-1980145","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"PI3K/AKT activation","react_pathway_id":"R-HSA-198203","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"PPARA activates gene expression","react_pathway_id":"R-HSA-1989781","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT","PTEN"],"pathway_name":"Negative regulation of the PI3K/AKT network","react_pathway_id":"R-HSA-199418","source":"CTD"},{"inference_gene_symbol":["AVP","EGFR","KIF21A"],"pathway_name":"Membrane Trafficking","react_pathway_id":"R-HSA-199991","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","SMARCA4","SOX2"],"pathway_name":"TCF dependent signaling in response to WNT","react_pathway_id":"R-HSA-201681","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","SMARCA4"],"pathway_name":"Formation of the beta-catenin:TCF transactivating complex","react_pathway_id":"R-HSA-201722","source":"CTD"},{"inference_gene_symbol":"COL4A2","pathway_name":"Assembly of collagen fibrils and other multimeric structures","react_pathway_id":"R-HSA-2022090","source":"CTD"},{"inference_gene_symbol":"PTEN","pathway_name":"TCR signaling","react_pathway_id":"R-HSA-202403","source":"CTD"},{"inference_gene_symbol":"PTEN","pathway_name":"Downstream TCR signaling","react_pathway_id":"R-HSA-202424","source":"CTD"},{"inference_gene_symbol":"CREBBP","pathway_name":"YAP1- and WWTR1 (TAZ)-stimulated gene expression","react_pathway_id":"R-HSA-2032785","source":"CTD"},{"inference_gene_symbol":"INSM1","pathway_name":"Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells","react_pathway_id":"R-HSA-210746","source":"CTD"},{"inference_gene_symbol":"EP300","pathway_name":"Epigenetic regulation of gene expression","react_pathway_id":"R-HSA-212165","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"NOTCH1 Intracellular Domain Regulates Transcription","react_pathway_id":"R-HSA-2122947","source":"CTD"},{"inference_gene_symbol":["CREBBP","EGFR","EP300","KIT","NDRG1","PTEN","TP53"],"pathway_name":"Generic Transcription Pathway","react_pathway_id":"R-HSA-212436","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR"],"pathway_name":"EGFR interacts with phospholipase C-gamma","react_pathway_id":"R-HSA-212718","source":"CTD"},{"inference_gene_symbol":"CREBBP","pathway_name":"Transcriptional activation of mitochondrial biogenesis","react_pathway_id":"R-HSA-2151201","source":"CTD"},{"inference_gene_symbol":"COL4A2","pathway_name":"Integrin cell surface interactions","react_pathway_id":"R-HSA-216083","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"DAP12 interactions","react_pathway_id":"R-HSA-2172127","source":"CTD"},{"inference_gene_symbol":"COL4A2","pathway_name":"Binding and Uptake of Ligands by Scavenger Receptors","react_pathway_id":"R-HSA-2173782","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"EGFR Transactivation by Gastrin","react_pathway_id":"R-HSA-2179392","source":"CTD"},{"inference_gene_symbol":"EP300","pathway_name":"NOTCH2 intracellular domain regulates transcription","react_pathway_id":"R-HSA-2197563","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"PI3K/AKT Signaling in Cancer","react_pathway_id":"R-HSA-2219528","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Constitutive Signaling by Aberrant PI3K in Cancer","react_pathway_id":"R-HSA-2219530","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Cellular response to hypoxia","react_pathway_id":"R-HSA-2262749","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","RB1","TP53"],"pathway_name":"Cellular responses to stress","react_pathway_id":"R-HSA-2262752","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Condensation of Prophase Chromosomes","react_pathway_id":"R-HSA-2299718","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","react_pathway_id":"R-HSA-2404192","source":"CTD"},{"inference_gene_symbol":["ADCY1","EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"DAP12 signaling","react_pathway_id":"R-HSA-2424491","source":"CTD"},{"inference_gene_symbol":"CREBBP","pathway_name":"Activation of gene expression by SREBF (SREBP)","react_pathway_id":"R-HSA-2426168","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"IGF1R signaling cascade","react_pathway_id":"R-HSA-2428924","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"IRS-related events triggered by IGF1R","react_pathway_id":"R-HSA-2428928","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"Fc epsilon receptor (FCERI) signaling","react_pathway_id":"R-HSA-2454202","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Oxidative Stress Induced Senescence","react_pathway_id":"R-HSA-2559580","source":"CTD"},{"inference_gene_symbol":["RB1","TP53"],"pathway_name":"Cellular Senescence","react_pathway_id":"R-HSA-2559583","source":"CTD"},{"inference_gene_symbol":["RB1","TP53"],"pathway_name":"Formation of Senescence-Associated Heterochromatin Foci (SAHF)","react_pathway_id":"R-HSA-2559584","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Oncogene Induced Senescence","react_pathway_id":"R-HSA-2559585","source":"CTD"},{"inference_gene_symbol":["RB1","TP53"],"pathway_name":"DNA Damage/Telomere Stress Induced Senescence","react_pathway_id":"R-HSA-2559586","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Signaling by Leptin","react_pathway_id":"R-HSA-2586552","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Signaling by NOTCH1 PEST Domain Mutants in Cancer","react_pathway_id":"R-HSA-2644602","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Signaling by NOTCH1 in Cancer","react_pathway_id":"R-HSA-2644603","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Constitutive Signaling by NOTCH1 PEST Domain Mutants","react_pathway_id":"R-HSA-2644606","source":"CTD"},{"inference_gene_symbol":"EPHA7","pathway_name":"EPH-Ephrin signaling","react_pathway_id":"R-HSA-2682334","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"Role of LAT2/NTAL/LAB on calcium mobilization","react_pathway_id":"R-HSA-2730905","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"FCERI mediated MAPK activation","react_pathway_id":"R-HSA-2871796","source":"CTD"},{"inference_gene_symbol":"SOX2","pathway_name":"POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation","react_pathway_id":"R-HSA-2892245","source":"CTD"},{"inference_gene_symbol":"SOX2","pathway_name":"POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation","react_pathway_id":"R-HSA-2892247","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","react_pathway_id":"R-HSA-2894858","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","react_pathway_id":"R-HSA-2894862","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"SUMOylation","react_pathway_id":"R-HSA-2990846","source":"CTD"},{"inference_gene_symbol":"COL4A2","pathway_name":"Scavenging by Class A Receptors","react_pathway_id":"R-HSA-3000480","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"SUMO E3 ligases SUMOylate target proteins","react_pathway_id":"R-HSA-3108232","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production","react_pathway_id":"R-HSA-3134973","source":"CTD"},{"inference_gene_symbol":"KMT2A","pathway_name":"PKMTs methylate histone lysines","react_pathway_id":"R-HSA-3214841","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"HATs acetylate histones","react_pathway_id":"R-HSA-3214847","source":"CTD"},{"inference_gene_symbol":"SMARCA4","pathway_name":"RMTs methylate histone arginines","react_pathway_id":"R-HSA-3214858","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"SUMOylation of transcription factors","react_pathway_id":"R-HSA-3232118","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","KMT2A","SMARCA4"],"pathway_name":"Chromatin modifying enzymes","react_pathway_id":"R-HSA-3247509","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Cellular response to heat stress","react_pathway_id":"R-HSA-3371556","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Attenuation phase","react_pathway_id":"R-HSA-3371568","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"HSF1-dependent transactivation","react_pathway_id":"R-HSA-3371571","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Autodegradation of the E3 ubiquitin ligase COP1","react_pathway_id":"R-HSA-349425","source":"CTD"},{"inference_gene_symbol":"CREBBP","pathway_name":"Notch-HLH transcription pathway","react_pathway_id":"R-HSA-350054","source":"CTD"},{"inference_gene_symbol":"CKB","pathway_name":"Metabolism of polyamines","react_pathway_id":"R-HSA-351202","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","NDRG1","PTEN","TP53"],"pathway_name":"Transcriptional Regulation by TP53","react_pathway_id":"R-HSA-3700989","source":"CTD"},{"inference_gene_symbol":["ADCY1","AVP","EGFR","FGFR1","GRM8","KIT"],"pathway_name":"Signaling by GPCR","react_pathway_id":"R-HSA-372790","source":"CTD"},{"inference_gene_symbol":"AVP","pathway_name":"Class A/1 (Rhodopsin-like receptors)","react_pathway_id":"R-HSA-373076","source":"CTD"},{"inference_gene_symbol":"SLIT2","pathway_name":"Netrin-1 signaling","react_pathway_id":"R-HSA-373752","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1"],"pathway_name":"L1CAM interactions","react_pathway_id":"R-HSA-373760","source":"CTD"},{"inference_gene_symbol":["COL4A2","EGFR","FGFR1","KIT"],"pathway_name":"NCAM signaling for neurite out-growth","react_pathway_id":"R-HSA-375165","source":"CTD"},{"inference_gene_symbol":"AVP","pathway_name":"Peptide ligand-binding receptors","react_pathway_id":"R-HSA-375276","source":"CTD"},{"inference_gene_symbol":"SLIT2","pathway_name":"Signaling by Robo receptor","react_pathway_id":"R-HSA-376176","source":"CTD"},{"inference_gene_symbol":"SOX2","pathway_name":"Deactivation of the beta-catenin transactivating complex","react_pathway_id":"R-HSA-3769402","source":"CTD"},{"inference_gene_symbol":"KHSRP","pathway_name":"ATF4 activates genes","react_pathway_id":"R-HSA-380994","source":"CTD"},{"inference_gene_symbol":"KHSRP","pathway_name":"PERK regulates gene expression","react_pathway_id":"R-HSA-381042","source":"CTD"},{"inference_gene_symbol":"KHSRP","pathway_name":"Unfolded Protein Response (UPR)","react_pathway_id":"R-HSA-381119","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Transcriptional regulation of white adipocyte differentiation","react_pathway_id":"R-HSA-381340","source":"CTD"},{"inference_gene_symbol":["ADCY1","AVP"],"pathway_name":"Transmembrane transport of small molecules","react_pathway_id":"R-HSA-382551","source":"CTD"},{"inference_gene_symbol":["ADCY1","AVP","GRM8"],"pathway_name":"GPCR downstream signaling","react_pathway_id":"R-HSA-388396","source":"CTD"},{"inference_gene_symbol":"AVP","pathway_name":"Vasopressin-like receptors","react_pathway_id":"R-HSA-388479","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Chaperonin-mediated protein folding","react_pathway_id":"R-HSA-390466","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Association of TriC/CCT with target proteins during biosynthesis","react_pathway_id":"R-HSA-390471","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Protein folding","react_pathway_id":"R-HSA-391251","source":"CTD"},{"inference_gene_symbol":["EP300","KHSRP","PTEN","TP53"],"pathway_name":"Metabolism of proteins","react_pathway_id":"R-HSA-392499","source":"CTD"},{"inference_gene_symbol":"EPHA7","pathway_name":"EPHA-mediated growth cone collapse","react_pathway_id":"R-HSA-3928663","source":"CTD"},{"inference_gene_symbol":"EPHA7","pathway_name":"EPH-ephrin mediated repulsion of cells","react_pathway_id":"R-HSA-3928665","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)","react_pathway_id":"R-HSA-400206","source":"CTD"},{"inference_gene_symbol":["AVP","CREBBP","EP300"],"pathway_name":"Circadian Clock","react_pathway_id":"R-HSA-400253","source":"CTD"},{"inference_gene_symbol":"AVP","pathway_name":"G alpha (q) signalling events","react_pathway_id":"R-HSA-416476","source":"CTD"},{"inference_gene_symbol":["ADCY1","AVP"],"pathway_name":"G alpha (s) signalling events","react_pathway_id":"R-HSA-418555","source":"CTD"},{"inference_gene_symbol":["ADCY1","GRM8"],"pathway_name":"G alpha (i) signalling events","react_pathway_id":"R-HSA-418594","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"G alpha (z) signalling events","react_pathway_id":"R-HSA-418597","source":"CTD"},{"inference_gene_symbol":"COL4A2","pathway_name":"NCAM1 interactions","react_pathway_id":"R-HSA-419037","source":"CTD"},{"inference_gene_symbol":"GRM8","pathway_name":"Class C/3 (Metabotropic glutamate/pheromone receptors)","react_pathway_id":"R-HSA-420499","source":"CTD"},{"inference_gene_symbol":["COL4A2","EGFR","EPHA7","FGFR1","KIT","SLIT2"],"pathway_name":"Axon guidance","react_pathway_id":"R-HSA-422475","source":"CTD"},{"inference_gene_symbol":"AVP","pathway_name":"Transport of vitamins, nucleosides, and related molecules","react_pathway_id":"R-HSA-425397","source":"CTD"},{"inference_gene_symbol":"AVP","pathway_name":"SLC-mediated transmembrane transport","react_pathway_id":"R-HSA-425407","source":"CTD"},{"inference_gene_symbol":"SLIT2","pathway_name":"Activation of Rac","react_pathway_id":"R-HSA-428540","source":"CTD"},{"inference_gene_symbol":"SLIT2","pathway_name":"Regulation of Commissural axon pathfinding by Slit and Robo","react_pathway_id":"R-HSA-428542","source":"CTD"},{"inference_gene_symbol":"SLIT2","pathway_name":"Inactivation of Cdc42 and Rac","react_pathway_id":"R-HSA-428543","source":"CTD"},{"inference_gene_symbol":"SLIT2","pathway_name":"Role of Abl in Robo-Slit signaling","react_pathway_id":"R-HSA-428890","source":"CTD"},{"inference_gene_symbol":["ADCY1","AVP"],"pathway_name":"Vasopressin regulates renal water homeostasis via Aquaporins","react_pathway_id":"R-HSA-432040","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Post NMDA receptor activation events","react_pathway_id":"R-HSA-438064","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"VEGFA-VEGFR2 Pathway","react_pathway_id":"R-HSA-4420097","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"CREB phosphorylation through the activation of Adenylate Cyclase","react_pathway_id":"R-HSA-442720","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Activation of NMDA receptor upon glutamate binding and postsynaptic events","react_pathway_id":"R-HSA-442755","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1"],"pathway_name":"Signal transduction by L1","react_pathway_id":"R-HSA-445144","source":"CTD"},{"inference_gene_symbol":["ADCY1","AVP"],"pathway_name":"Aquaporin-mediated transport","react_pathway_id":"R-HSA-445717","source":"CTD"},{"inference_gene_symbol":["CSF3","EGFR","FGFR1","KIT","SMARCA4","SOX2","TP53"],"pathway_name":"Signaling by Interleukins","react_pathway_id":"R-HSA-449147","source":"CTD"},{"inference_gene_symbol":"KHSRP","pathway_name":"Regulation of mRNA stability by proteins that bind AU-rich elements","react_pathway_id":"R-HSA-450531","source":"CTD"},{"inference_gene_symbol":"KHSRP","pathway_name":"KSRP (KHSRP) binds and destabilizes mRNA","react_pathway_id":"R-HSA-450604","source":"CTD"},{"inference_gene_symbol":"GRIK3","pathway_name":"Ionotropic activity of Kainate Receptors","react_pathway_id":"R-HSA-451306","source":"CTD"},{"inference_gene_symbol":"GRIK3","pathway_name":"Activation of Ca-permeable Kainate Receptor","react_pathway_id":"R-HSA-451308","source":"CTD"},{"inference_gene_symbol":"GRIK3","pathway_name":"Activation of Kainate Receptors upon glutamate binding","react_pathway_id":"R-HSA-451326","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Interleukin-2 signaling","react_pathway_id":"R-HSA-451927","source":"CTD"},{"inference_gene_symbol":"SOX2","pathway_name":"Transcriptional regulation of pluripotent stem cells","react_pathway_id":"R-HSA-452723","source":"CTD"},{"inference_gene_symbol":["EP300","TP53"],"pathway_name":"Mitotic G2-G2/M phases","react_pathway_id":"R-HSA-453274","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Mitotic G1-G1/S phases","react_pathway_id":"R-HSA-453279","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","KMT2A","SMARCA4"],"pathway_name":"Chromatin organization","react_pathway_id":"R-HSA-4839726","source":"CTD"},{"inference_gene_symbol":"GRIK3","pathway_name":"Presynaptic function of Kainate receptors","react_pathway_id":"R-HSA-500657","source":"CTD"},{"inference_gene_symbol":["AVP","GRM8"],"pathway_name":"GPCR ligand binding","react_pathway_id":"R-HSA-500792","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Interleukin-3, 5 and GM-CSF signaling","react_pathway_id":"R-HSA-512988","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"VEGFR2 mediated cell proliferation","react_pathway_id":"R-HSA-5218921","source":"CTD"},{"inference_gene_symbol":"EP300","pathway_name":"Positive epigenetic regulation of rRNA expression","react_pathway_id":"R-HSA-5250913","source":"CTD"},{"inference_gene_symbol":"EP300","pathway_name":"B-WICH complex positively regulates rRNA expression","react_pathway_id":"R-HSA-5250924","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Fatty acid, triacylglycerol, and ketone body metabolism","react_pathway_id":"R-HSA-535734","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Programmed Cell Death","react_pathway_id":"R-HSA-5357801","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Signaling by Hedgehog","react_pathway_id":"R-HSA-5358351","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","PTEN"],"pathway_name":"Metabolism of lipids and lipoproteins","react_pathway_id":"R-HSA-556833","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Hedgehog 'off' state","react_pathway_id":"R-HSA-5610787","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Activation of anterior HOX genes in hindbrain development during early embryogenesis","react_pathway_id":"R-HSA-5617472","source":"CTD"},{"inference_gene_symbol":"AVP","pathway_name":"Defective AVP causes neurohypophyseal diabetes insipidus (NDI)","react_pathway_id":"R-HSA-5619099","source":"CTD"},{"inference_gene_symbol":"AVP","pathway_name":"SLC transporter disorders","react_pathway_id":"R-HSA-5619102","source":"CTD"},{"inference_gene_symbol":"AVP","pathway_name":"Disorders of transmembrane transporters","react_pathway_id":"R-HSA-5619115","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Activation of HOX genes during differentiation","react_pathway_id":"R-HSA-5619507","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"C-type lectin receptors (CLRs)","react_pathway_id":"R-HSA-5621481","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"CD209 (DC-SIGN) signaling","react_pathway_id":"R-HSA-5621575","source":"CTD"},{"inference_gene_symbol":["PTEN","TP53"],"pathway_name":"TP53 Regulates Metabolic Genes","react_pathway_id":"R-HSA-5628897","source":"CTD"},{"inference_gene_symbol":["EP300","TP53"],"pathway_name":"Regulation of TP53 Activity","react_pathway_id":"R-HSA-5633007","source":"CTD"},{"inference_gene_symbol":["CREBBP","NDRG1","TP53"],"pathway_name":"TP53 Regulates Transcription of Cell Death Genes","react_pathway_id":"R-HSA-5633008","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"Constitutive Signaling by EGFRvIII","react_pathway_id":"R-HSA-5637810","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"Signaling by EGFRvIII in Cancer","react_pathway_id":"R-HSA-5637812","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"Signaling by Ligand-Responsive EGFR Variants in Cancer","react_pathway_id":"R-HSA-5637815","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"Signaling by Overexpressed Wild-Type EGFR in Cancer","react_pathway_id":"R-HSA-5638302","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"Inhibition of Signaling by Overexpressed EGFR","react_pathway_id":"R-HSA-5638303","source":"CTD"},{"inference_gene_symbol":["AVP","COL4A2","EGFR","KIF21A"],"pathway_name":"Vesicle-mediated transport","react_pathway_id":"R-HSA-5653656","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"Phospholipase C-mediated cascade: FGFR1","react_pathway_id":"R-HSA-5654219","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"Downstream signaling of activated FGFR1","react_pathway_id":"R-HSA-5654687","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"SHC-mediated cascade:FGFR1","react_pathway_id":"R-HSA-5654688","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"PI-3K cascade:FGFR1","react_pathway_id":"R-HSA-5654689","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"FRS-mediated FGFR1 signaling","react_pathway_id":"R-HSA-5654693","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"Negative regulation of FGFR1 signaling","react_pathway_id":"R-HSA-5654726","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"Signaling by FGFR1","react_pathway_id":"R-HSA-5654736","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"Signaling by FGFR1 in disease","react_pathway_id":"R-HSA-5655302","source":"CTD"},{"inference_gene_symbol":["CREBBP","EGFR","EP300","FGFR1","KIT"],"pathway_name":"Diseases of signal transduction","react_pathway_id":"R-HSA-5663202","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"RAF/MAP kinase cascade","react_pathway_id":"R-HSA-5673001","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"MAPK family signaling cascades","react_pathway_id":"R-HSA-5683057","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"MAPK1/MAPK3 signaling","react_pathway_id":"R-HSA-5684996","source":"CTD"},{"inference_gene_symbol":["EP300","PTEN","TP53"],"pathway_name":"Deubiquitination","react_pathway_id":"R-HSA-5688426","source":"CTD"},{"inference_gene_symbol":["PTEN","TP53"],"pathway_name":"Ub-specific processing proteases","react_pathway_id":"R-HSA-5689880","source":"CTD"},{"inference_gene_symbol":["PTEN","TP53"],"pathway_name":"Ovarian tumor domain proteases","react_pathway_id":"R-HSA-5689896","source":"CTD"},{"inference_gene_symbol":"EP300","pathway_name":"Metalloprotease DUBs","react_pathway_id":"R-HSA-5689901","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"DNA Double-Strand Break Repair","react_pathway_id":"R-HSA-5693532","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks","react_pathway_id":"R-HSA-5693565","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"DNA Double Strand Break Response","react_pathway_id":"R-HSA-5693606","source":"CTD"},{"inference_gene_symbol":"EP300","pathway_name":"Nucleotide Excision Repair","react_pathway_id":"R-HSA-5696398","source":"CTD"},{"inference_gene_symbol":["EP300","PTEN","TP53"],"pathway_name":"Post-translational protein modification","react_pathway_id":"R-HSA-597592","source":"CTD"},{"inference_gene_symbol":"EP300","pathway_name":"Formation of TC-NER Pre-Incision Complex","react_pathway_id":"R-HSA-6781823","source":"CTD"},{"inference_gene_symbol":"EP300","pathway_name":"Transcription-Coupled Nucleotide Excision Repair (TC-NER)","react_pathway_id":"R-HSA-6781827","source":"CTD"},{"inference_gene_symbol":"EP300","pathway_name":"Dual incision in TC-NER","react_pathway_id":"R-HSA-6782135","source":"CTD"},{"inference_gene_symbol":"EP300","pathway_name":"Gap-filling DNA repair synthesis and ligation in TC-NER","react_pathway_id":"R-HSA-6782210","source":"CTD"},{"inference_gene_symbol":"CSF3","pathway_name":"Interleukin-10 signaling","react_pathway_id":"R-HSA-6783783","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"ERBB2 Regulates Cell Motility","react_pathway_id":"R-HSA-6785631","source":"CTD"},{"inference_gene_symbol":["SOX2","TP53"],"pathway_name":"Interleukin-4 and 13 signaling","react_pathway_id":"R-HSA-6785807","source":"CTD"},{"inference_gene_symbol":["EP300","TP53"],"pathway_name":"TP53 Regulates Transcription of Cell Cycle Genes","react_pathway_id":"R-HSA-6791312","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 Regulates Transcription of DNA Repair Genes","react_pathway_id":"R-HSA-6796648","source":"CTD"},{"inference_gene_symbol":["CREBBP","TP53"],"pathway_name":"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release","react_pathway_id":"R-HSA-6803204","source":"CTD"},{"inference_gene_symbol":["NDRG1","TP53"],"pathway_name":"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","react_pathway_id":"R-HSA-6803205","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 Regulates Transcription of Caspase Activators and Caspases","react_pathway_id":"R-HSA-6803207","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 Regulates Transcription of Death Receptors and Ligands","react_pathway_id":"R-HSA-6803211","source":"CTD"},{"inference_gene_symbol":["EP300","TP53"],"pathway_name":"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","react_pathway_id":"R-HSA-6804114","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","react_pathway_id":"R-HSA-6804115","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest","react_pathway_id":"R-HSA-6804116","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Regulation of TP53 Expression","react_pathway_id":"R-HSA-6804754","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Regulation of TP53 Activity through Phosphorylation","react_pathway_id":"R-HSA-6804756","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Regulation of TP53 Degradation","react_pathway_id":"R-HSA-6804757","source":"CTD"},{"inference_gene_symbol":["EP300","TP53"],"pathway_name":"Regulation of TP53 Activity through Acetylation","react_pathway_id":"R-HSA-6804758","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Regulation of TP53 Activity through Association with Co-factors","react_pathway_id":"R-HSA-6804759","source":"CTD"},{"inference_gene_symbol":["EP300","TP53"],"pathway_name":"Regulation of TP53 Activity through Methylation","react_pathway_id":"R-HSA-6804760","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Regulation of TP53 Expression and Degradation","react_pathway_id":"R-HSA-6806003","source":"CTD"},{"inference_gene_symbol":"KIF21A","pathway_name":"COPI-dependent Golgi-to-ER retrograde traffic","react_pathway_id":"R-HSA-6811434","source":"CTD"},{"inference_gene_symbol":"KIF21A","pathway_name":"Intra-Golgi and retrograde Golgi-to-ER traffic","react_pathway_id":"R-HSA-6811442","source":"CTD"},{"inference_gene_symbol":["EP300","TP53"],"pathway_name":"PI5P Regulates TP53 Acetylation","react_pathway_id":"R-HSA-6811555","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling","react_pathway_id":"R-HSA-6811558","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Mitotic Prophase","react_pathway_id":"R-HSA-68875","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"M Phase","react_pathway_id":"R-HSA-68886","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Orc1 removal from chromatin","react_pathway_id":"R-HSA-68949","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Switching of origins to a post-replicative state","react_pathway_id":"R-HSA-69052","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes","react_pathway_id":"R-HSA-69200","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Cyclin E associated events during G1/S transition","react_pathway_id":"R-HSA-69202","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"G1/S Transition","react_pathway_id":"R-HSA-69206","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Cyclin D associated events in G1","react_pathway_id":"R-HSA-69231","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"G1 Phase","react_pathway_id":"R-HSA-69236","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Synthesis of DNA","react_pathway_id":"R-HSA-69239","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"S Phase","react_pathway_id":"R-HSA-69242","source":"CTD"},{"inference_gene_symbol":["EP300","TP53"],"pathway_name":"G2/M Transition","react_pathway_id":"R-HSA-69275","source":"CTD"},{"inference_gene_symbol":["EP300","RB1","TP53"],"pathway_name":"Cell Cycle, Mitotic","react_pathway_id":"R-HSA-69278","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Removal of licensing factors from origins","react_pathway_id":"R-HSA-69300","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Regulation of DNA replication","react_pathway_id":"R-HSA-69304","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"DNA Replication","react_pathway_id":"R-HSA-69306","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"G2/M DNA damage checkpoint","react_pathway_id":"R-HSA-69473","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"G2/M Checkpoints","react_pathway_id":"R-HSA-69481","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Stabilization of p53","react_pathway_id":"R-HSA-69541","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Transcriptional activation of p53 responsive genes","react_pathway_id":"R-HSA-69560","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"p53-Dependent G1 DNA Damage Response","react_pathway_id":"R-HSA-69563","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"p53-Dependent G1/S DNA damage checkpoint","react_pathway_id":"R-HSA-69580","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"G1/S DNA Damage Checkpoints","react_pathway_id":"R-HSA-69615","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Cell Cycle Checkpoints","react_pathway_id":"R-HSA-69620","source":"CTD"},{"inference_gene_symbol":"RB1","pathway_name":"Cyclin A:Cdk2-associated events at S phase entry","react_pathway_id":"R-HSA-69656","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Transcriptional  activation of  cell cycle inhibitor p21","react_pathway_id":"R-HSA-69895","source":"CTD"},{"inference_gene_symbol":"CKB","pathway_name":"Creatine metabolism","react_pathway_id":"R-HSA-71288","source":"CTD"},{"inference_gene_symbol":"CKB","pathway_name":"Metabolism of amino acids and derivatives","react_pathway_id":"R-HSA-71291","source":"CTD"},{"inference_gene_symbol":"ELAVL2","pathway_name":"mRNA Splicing - Major Pathway","react_pathway_id":"R-HSA-72163","source":"CTD"},{"inference_gene_symbol":"ELAVL2","pathway_name":"mRNA Splicing","react_pathway_id":"R-HSA-72172","source":"CTD"},{"inference_gene_symbol":"ELAVL2","pathway_name":"Processing of Capped Intron-Containing Pre-mRNA","react_pathway_id":"R-HSA-72203","source":"CTD"},{"inference_gene_symbol":["EP300","TP53"],"pathway_name":"DNA Repair","react_pathway_id":"R-HSA-73894","source":"CTD"},{"inference_gene_symbol":["CREBBP","EGFR","ELAVL2","EP300","KHSRP","KIT","NDRG1","PTEN","TP53"],"pathway_name":"Gene Expression","react_pathway_id":"R-HSA-74160","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Insulin receptor signalling cascade","react_pathway_id":"R-HSA-74751","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Signaling by Insulin receptor","react_pathway_id":"R-HSA-74752","source":"CTD"},{"inference_gene_symbol":"AVP","pathway_name":"Transport of organic anions","react_pathway_id":"R-HSA-879518","source":"CTD"},{"inference_gene_symbol":["AVP","EGFR","FGFR1","KIT"],"pathway_name":"Gastrin-CREB signalling pathway via PKC and MAPK","react_pathway_id":"R-HSA-881907","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"ERBB2 Activates PTK6 Signaling","react_pathway_id":"R-HSA-8847993","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"Signaling by PTK6","react_pathway_id":"R-HSA-8848021","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"The role of GTSE1 in G2/M progression after G2 checkpoint","react_pathway_id":"R-HSA-8852276","source":"CTD"},{"inference_gene_symbol":"FGFR1","pathway_name":"Signaling by plasma membrane FGFR1 fusions","react_pathway_id":"R-HSA-8853336","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"RET signaling","react_pathway_id":"R-HSA-8853659","source":"CTD"},{"inference_gene_symbol":"KIF21A","pathway_name":"Golgi-to-ER retrograde transport","react_pathway_id":"R-HSA-8856688","source":"CTD"},{"inference_gene_symbol":["AVP","EGFR"],"pathway_name":"Cargo recognition for clathrin-mediated endocytosis","react_pathway_id":"R-HSA-8856825","source":"CTD"},{"inference_gene_symbol":["AVP","EGFR"],"pathway_name":"Clathrin-mediated endocytosis","react_pathway_id":"R-HSA-8856828","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"PTK6 promotes HIF1A stabilization","react_pathway_id":"R-HSA-8857538","source":"CTD"},{"inference_gene_symbol":"EGFR","pathway_name":"Downregulation of ERBB2 signaling","react_pathway_id":"R-HSA-8863795","source":"CTD"},{"inference_gene_symbol":["CREBBP","EGFR","EP300","KIT"],"pathway_name":"Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","react_pathway_id":"R-HSA-8864260","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"Activation of the TFAP2 (AP-2) family of transcription factors","react_pathway_id":"R-HSA-8866907","source":"CTD"},{"inference_gene_symbol":["EGFR","KIT"],"pathway_name":"TFAP2 (AP-2) family regulates transcription of growth factors and their receptors","react_pathway_id":"R-HSA-8866910","source":"CTD"},{"inference_gene_symbol":["COL22A1","COL4A2"],"pathway_name":"Collagen chain trimerization","react_pathway_id":"R-HSA-8948216","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT"],"pathway_name":"Interleukin receptor SHC signaling","react_pathway_id":"R-HSA-912526","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"TRAF3-dependent IRF activation pathway","react_pathway_id":"R-HSA-918233","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300"],"pathway_name":"TRAF6 mediated IRF7 activation","react_pathway_id":"R-HSA-933541","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"GABA receptor activation","react_pathway_id":"R-HSA-977443","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"GABA B receptor activation","react_pathway_id":"R-HSA-977444","source":"CTD"},{"inference_gene_symbol":"KIF21A","pathway_name":"Kinesins","react_pathway_id":"R-HSA-983189","source":"CTD"},{"inference_gene_symbol":["CREBBP","EP300","KIF21A","TP53"],"pathway_name":"Factors involved in megakaryocyte development and platelet production","react_pathway_id":"R-HSA-983231","source":"CTD"},{"inference_gene_symbol":["EGFR","FGFR1","KIT","PTEN","TP53"],"pathway_name":"Signaling by the B Cell Receptor (BCR)","react_pathway_id":"R-HSA-983705","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Activation of GABAB receptors","react_pathway_id":"R-HSA-991365","source":"CTD"},{"inference_gene_symbol":"ADCY1","pathway_name":"Inhibition of adenylate cyclase pathway","react_pathway_id":"R-HSA-997269","source":"CTD"}]},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:1579","DOID:0050615","DOID:3905","DOID:1324","DOID:4","DOID:850","DOID:162","DOID:305","DOID:0050161","DOID:7","DOID:14566","DOID:0050687","DOID:0050686"],"children":["DOID:5411","DOID:5414","DOID:5421"],"def":"\"A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells and is located_in the lung.\" [url:http\\://en.wikipedia.org/wiki/Small-cell_carcinoma]","descendants":["DOID:5411","DOID:5421","DOID:0050917","DOID:5414"],"doid":"DOID:5409","name":"lung small cell carcinoma","parents":["DOID:3905"],"synonyms":{},"xrefs":{"kegg":"05222","mesh":"D055752","mim":"182280","ncit":"C4917","snomedct_us_2025_09_01":"254632001","umls_cui":"C0149925"}},"hpo":{"disease_name":"Small cell cancer of the lung","inheritance":{"biocuration":{"date":"2009-02-17","name":"HPO:iea"},"evidence":"TAS","hpo_id":"HP:0000006","hpo_name":"Autosomal dominant inheritance","omim_refs":"OMIM:182280","original_disease_id":"OMIM:182280"},"omim":"182280","phenotype_related_to_disease":{"biocuration":{"date":"2026-06-19","name":"ORCID:0000-0002-0736-9199"},"evidence":"PCS","hpo_id":"HP:0030357","original_disease_id":"OMIM:182280","pmid_refs":"PMID:26168399"}},"mondo":{"ancestors":["MONDO:0019496","MONDO:0000270","MONDO:0002120","MONDO:0000001","MONDO:0045024","MONDO:0005138","MONDO:0005275","MONDO:0004992","MONDO:0008903","MONDO:0005087","MONDO:7770008","MONDO:0000402","MONDO:0005454","MONDO:0021069","MONDO:0005070","MONDO:0021117","MONDO:7770006","MONDO:0005151","MONDO:0005626","MONDO:0023370","MONDO:0002082","MONDO:0021350","MONDO:0004993","MONDO:0003274","MONDO:0700096","MONDO:0020641","MONDO:0000376"],"children":["MONDO:0003437","MONDO:0003438"],"definition":"Small cell lung cancer (SCLC) is a highly aggressive malignant neoplasm, accounting for 10-15% of lung cancer cases, characterized byrapid growth, and early metastasis. SCLC usually manifests as a large hilar mass with bulky mediastinal lymphadenopathy presenting clinically with chest pain, persistent cough, dyspnea, wheezing, hoarseness, hemoptysis, loss of appetite, weight loss, and neurological and endocrine paraneoplastic syndromes. SCLC is primarily reported in elderly people with a history of long-term tobacco exposure. [Orphanet:70573]","descendants":["MONDO:0003437","MONDO:0000532","MONDO:0003438"],"label":"small cell lung carcinoma","mondo":"MONDO:0008433","parents":["MONDO:0000402","MONDO:0005138","MONDO:0005454"],"synonym":{"exact":["lung oat cell carcinoma","lung small cell carcinoma","lung small cell neuroendocrine carcinoma","oat cell carcinoma of lung","oat cell carcinoma of the lung","oat cell lung carcinoma","small cell cancer of the lung, somatic","small cell carcinoma of lung","small cell carcinoma of the lung","Small cell lung cancer","small cell lung cancer","small cell neuroendocrine carcinoma of lung","small cell neuroendocrine carcinoma of the lung","small-cell cancer of lung"],"related":["SCLC1"]},"xrefs":{"doid":["DOID:5409","DOID:5411"],"efo":["EFO:0000702"],"gard":["0009344"],"icd11":["foundation:1800431439"],"icd9":["162.9"],"medgen":["57450"],"mesh":["D055752"],"ncit":["C4917"],"omim":["182280"],"oncotree":["SCLC"],"orphanet":["70573"],"sctid":["254632001"],"umls":["C0149925"]}},"umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"non-preferred":"D055752","preferred":"D055752"},"nci":{"non-preferred":"C4917","preferred":"C4917"},"snomed":{"non-preferred":["254632001","254633006"],"preferred":"254632001"},"umls":"C0149925"}}