{"_id":"MONDO:0008039","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"53-03-2","chemical_name":"Prednisone","direct_evidence":"therapeutic","mesh_chemical_id":"D011241","pubmed":"9699373","source":"CTD"},{"cas_registry_number":"302-04-5","chemical_name":"thiocyanate","direct_evidence":"marker/mechanism","mesh_chemical_id":"C031760","pubmed":"27246648","source":"CTD"},{"cas_registry_number":"30516-87-1","chemical_name":"Zidovudine","direct_evidence":"therapeutic","mesh_chemical_id":"D015215","pubmed":"8413977","source":"CTD"}],"mesh":"D015493"},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:934","DOID:331","DOID:4","DOID:7","DOID:319","DOID:863","DOID:0050117"],"children":[],"def":"\"A viral infectious disease that results in inflammation located in spinal cord, has_material_basis_in human T-cell leukemia virus type 1 (Deltaretrovirus priTlym1), which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.\" [url:http\\://en.wikipedia.org/wiki/Tropical_spastic_paraparesis, url:https\\://www.merckmanuals.com/professional/neurologic-disorders/spinal-cord-disorders/htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp, url:https\\://www.ncbi.nlm.nih.gov/books/NBK560825/, url:https\\://www.ninds.nih.gov/health-information/disorders/htlv-1-associated-myelopathy-hamtropical-spastic-paraparesis-tsp]","descendants":[],"doid":"DOID:321","name":"HTLV-1-associated myelopathy/tropical spastic paraparesis","parents":["DOID:319","DOID:934"],"synonyms":{"exact":["HAM/TSP","HTLV-associated myelopathy","Tropical spastic paralysis","tropical spastic paraparesis","Tropical spastic paraplegia"]},"xrefs":{"icd10":"G04.1","mesh":"D015493","mim":"159580","ncit":"C179058","snomedct_us_2025_09_01":"45129002","umls_cui":"C0030481"}},"hpo":{"disease_name":"Myelopathy, htlv-1-associated","omim":"159580","phenotype_related_to_disease":[{"biocuration":{"date":"2009-02-17","name":"HPO:probinson"},"evidence":"TAS","hpo_id":"HP:0002196","omim_refs":"OMIM:159580","original_disease_id":"OMIM:159580"},{"biocuration":{"date":"2014-11-15","name":"HPO:probinson"},"evidence":"TAS","hpo_id":"HP:0007256","omim_refs":"OMIM:159580","original_disease_id":"OMIM:159580"},{"biocuration":{"date":"2014-11-15","name":"HPO:probinson"},"evidence":"TAS","hpo_id":"HP:0002313","omim_refs":"OMIM:159580","original_disease_id":"OMIM:159580"}]},"mondo":{"ancestors":["MONDO:0700096","MONDO:0000001","MONDO:7770010","MONDO:0005071","MONDO:0005108","MONDO:0005801","MONDO:0020010","MONDO:7770006","MONDO:0005550","MONDO:7770008"],"definition":"Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection. [Orphanet:289326]","disease_has_feature":{"hp":["HP:0001324"]},"label":"tropical spastic paraparesis","mondo":"MONDO:0008039","parents":["MONDO:0005801","MONDO:0020010"],"synonym":{"exact":["HAM/TSP","ham/TSP","HTLV-1-associated myelopathy/tropical spastic paraparesis","Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis","Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis","tropical spastic paraplegia","TSP"],"related":["ham","HTLV-1 associated myelopathy/tropical spastic paraparesis","Human T-cell leukaemia virus type 1 associated myelopathy/tropical spastic paraparesis","Human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis","myelopathy, HTLV-1-associated","tropical spastic paraparesis (formerly)"]},"xrefs":{"doid":["DOID:321"],"efo":["EFO:0007527"],"gard":["0008208"],"icd10cm":["G04.1"],"icd11":["foundation:1043229589"],"icd9":["323.01"],"meddra":["10044696"],"medgen":["18298"],"mesh":["D015493"],"nando":["1200206"],"omim":["159580"],"orphanet":["289326"],"sctid":["714279000"],"umls":["C0030481"]}},"umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"non-preferred":"G04.1"},"icd10am":{"non-preferred":"G04.1"},"icd10cm":{"non-preferred":"G04.1"},"mesh":{"non-preferred":"D015493","preferred":"D015493"},"nci":{"non-preferred":"C179058"},"snomed":{"non-preferred":["45129002","192733005","714279000"],"preferred":["45129002","714279000"]},"umls":"C0030481"}}