{"_id":"MONDO:0007753","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"523-87-5","chemical_name":"Dimenhydrinate","direct_evidence":"therapeutic","mesh_chemical_id":"D004111","pubmed":"12189776","source":"CTD"},{"cas_registry_number":"596-51-0","chemical_name":"Glycopyrrolate","direct_evidence":"therapeutic","mesh_chemical_id":"D006024","pubmed":"12950111","source":"CTD"}],"mesh":"D013547"},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:4","DOID:574","DOID:11465","DOID:863","DOID:7"],"children":[],"def":"\"An autonomic nervous system disease that is characterized by facial sweating and flushing with gustatory stimulation, resulting from a disruption of the auriculotemporal nerve pathways.\" [url:https\\://pubmed.ncbi.nlm.nih.gov/12269550/]","descendants":[],"doid":"DOID:11599","name":"Frey syndrome","parents":["DOID:11465"],"synonyms":{"exact":["Baillarger syndrome","gustatory hyperhidrosis","gustatory sweating"]},"xrefs":{"gard":"6467","mesh":"D013547","mim":"144100","snomedct_us_2025_09_01":"56046002","umls_cui":"C0038994"}},"hpo":{"disease_name":"Hyperhidrosis, gustatory","inheritance":{"biocuration":{"date":"2009-02-17","name":"HPO:iea"},"evidence":"IEA","hpo_id":"HP:0000006","hpo_name":"Autosomal dominant inheritance","omim_refs":"OMIM:144100","original_disease_id":"OMIM:144100"},"omim":"144100","phenotype_related_to_disease":{"biocuration":{"date":"2009-02-17","name":"HPO:probinson"},"evidence":"TAS","hpo_id":"HP:0000975","omim_refs":"OMIM:144100","original_disease_id":"OMIM:144100"}},"mondo":{"ancestors":["MONDO:0001292","MONDO:0700096","MONDO:7770009","MONDO:0000001","MONDO:0005071","MONDO:7770006","MONDO:0002602","MONDO:0003847","MONDO:0003620","MONDO:0100545","MONDO:7770008"],"definition":"An autonomic disorder characterized by excessive sweating of the forehead, upper lip, perioral region, or sternum subsequent to gustatory stimuli. The auriculotemporal syndrome features facial flushing or sweating limited to the distribution of the auriculotemporal nerve and may develop after trauma to the parotid gland, in association with parotid neoplasms, or following their surgical removal. (From Ann Neurol 1997 Dec;42(6):973-5) [MESH:D013547]","label":"Frey syndrome","mondo":"MONDO:0007753","parents":["MONDO:0001292","MONDO:0100545"],"synonym":{"exact":["Baillarger syndrome","Frey syndrome","gustatory hyperhidrosis","gustatory sweating"],"related":["Frey's syndrome","hyperhidrosis gustatory","hyperhidrosis, gustatory","HYPRG"]},"xrefs":{"doid":["DOID:11599"],"efo":["EFO:1000940"],"gard":["0027052"],"medgen":["21041"],"mesh":["D013547"],"omim":["144100"],"orphanet":["662240"],"sctid":["238758008"],"umls":["C0038994"]}},"umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"non-preferred":"D013547","preferred":"D013547"},"snomed":{"non-preferred":["45294007","238758008","56046002"],"preferred":"56046002"},"umls":"C0038994"}}