{"_id":"MONDO:0006908","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"25614-03-3","chemical_name":"Bromocriptine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D001971","pubmed":["3226523","4020451","7293648"],"source":"CTD"},{"cas_registry_number":"50-53-3","chemical_name":"Chlorpromazine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D002746","pubmed":"718334","source":"CTD"},{"cas_registry_number":"911-45-5","chemical_name":"Clomiphene","direct_evidence":"marker/mechanism","mesh_chemical_id":"D002996","pubmed":"8731710","source":"CTD"},{"cas_registry_number":"50-02-2","chemical_name":"Dexamethasone","direct_evidence":"therapeutic","mesh_chemical_id":"D003907","pubmed":["12699433","12699434"],"source":"CTD"},{"cas_registry_number":"80529-93-7","chemical_name":"Gadolinium DTPA","direct_evidence":"marker/mechanism","mesh_chemical_id":"D019786","pubmed":"9401663","source":"CTD"},{"cas_registry_number":"9005-49-6","chemical_name":"Heparin","direct_evidence":"marker/mechanism","mesh_chemical_id":"D006493","pubmed":["11958251","15251667","9365341"],"source":"CTD"},{"cas_registry_number":"16051-77-7","chemical_name":"isosorbide-5-mononitrate","direct_evidence":"marker/mechanism","mesh_chemical_id":"C030397","pubmed":"3585391","source":"CTD"},{"cas_registry_number":"87-33-2","chemical_name":"Isosorbide Dinitrate","direct_evidence":"marker/mechanism","mesh_chemical_id":"D007548","pubmed":"11958251","source":"CTD"},{"cas_registry_number":"53714-56-0","chemical_name":"Leuprolide","direct_evidence":"marker/mechanism","mesh_chemical_id":"D016729","pubmed":["12507807","16832587","19842040","8706284","9413812"],"source":"CTD"}],"mesh":"D010899","pathway_related_to_disease":[{"inference_gene_symbol":"CRH","kegg_pathway_id":"hsa04730","pathway_name":"Long-term depression","source":"CTD"},{"inference_gene_symbol":"CRH","kegg_pathway_id":"hsa05034","pathway_name":"Alcoholism","source":"CTD"},{"inference_gene_symbol":"CRH","pathway_name":"Signal Transduction","react_pathway_id":"R-HSA-162582","source":"CTD"},{"inference_gene_symbol":"CRH","pathway_name":"Signaling by GPCR","react_pathway_id":"R-HSA-372790","source":"CTD"},{"inference_gene_symbol":"CRH","pathway_name":"Class B/2 (Secretin family receptors)","react_pathway_id":"R-HSA-373080","source":"CTD"},{"inference_gene_symbol":"CRH","pathway_name":"GPCR downstream signaling","react_pathway_id":"R-HSA-388396","source":"CTD"},{"inference_gene_symbol":"CRH","pathway_name":"G alpha (s) signalling events","react_pathway_id":"R-HSA-418555","source":"CTD"},{"inference_gene_symbol":"CRH","pathway_name":"GPCR ligand binding","react_pathway_id":"R-HSA-500792","source":"CTD"}]},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:3646","DOID:1130","DOID:4","DOID:7","DOID:28","DOID:53"],"children":[],"def":"","descendants":[],"doid":"DOID:1129","name":"pituitary apoplexy","parents":["DOID:1130"],"synonyms":{},"xrefs":{"mesh":"D010899","ncit":"C26853","snomedct_us_2025_09_01":"237701005","umls_cui":"C0032001"}},"hpo":{"disease_name":"Pituitary apoplexy","orphanet":"95613","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0030521","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0030907","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000651","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000802","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000815","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000822","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000876","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001943","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002017","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002315","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002615","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002893","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002902","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0006824","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0008202","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0008245","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0011748","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0030591","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0030595","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000508","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000613","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000622","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000824","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000870","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000980","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001259","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001945","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002921","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0007663","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0011499","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0012378","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0040075","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0100829","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0000845","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0000863","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001262","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001289","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001895","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0002339","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0003118","orphanet_refs":"orphanet:95613"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0100661","orphanet_refs":"orphanet:95613"}]},"mondo":{"ancestors":["MONDO:0005560","MONDO:0000001","MONDO:0002602","MONDO:0003381","MONDO:0015127","MONDO:0001259","MONDO:0002721","MONDO:0005039","MONDO:0005071","MONDO:7770006","MONDO:0005151","MONDO:0700096","MONDO:0005152","MONDO:0019832"],"definition":"A rare, potentially life-threatening disorder caused by acute ischemic infarction or hemorrhage in the pituitary gland. It is most often associated with the presence of a pituitary gland adenoma. Signs and symptoms include headache, vomiting, visual disturbances, and endocrine dysfunction. [NCIT:P378]","label":"pituitary apoplexy","mondo":"MONDO:0006908","parents":["MONDO:0001259","MONDO:0019832"],"synonym":{"exact":["pituitary gland apoplexy"]},"xrefs":{"doid":["DOID:1129"],"efo":["EFO:1001108"],"gard":["0019287"],"icd11":["foundation:1938573221"],"icd9":["253.8"],"meddra":["10056447"],"medgen":["18489"],"mesh":["D010899"],"ncit":["C26853"],"orphanet":["95613"],"sctid":["237701005"],"umls":["C0032001"]}},"original_id":"orphanet:95613","umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"preferred":"D010899"},"nci":{"non-preferred":"C26853","preferred":"C26853"},"snomed":{"non-preferred":"237701005","preferred":"237701005"},"umls":"C0032001"}}