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disease","source":"CTD"},{"inference_gene_symbol":"SOD2","pathway_name":"Disease","react_pathway_id":"R-HSA-1643685","source":"CTD"},{"inference_gene_symbol":"SOD2","pathway_name":"Cellular responses to stress","react_pathway_id":"R-HSA-2262752","source":"CTD"},{"inference_gene_symbol":"SOD2","pathway_name":"Detoxification of Reactive Oxygen Species","react_pathway_id":"R-HSA-3299685","source":"CTD"},{"inference_gene_symbol":"SOD2","pathway_name":"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","react_pathway_id":"R-HSA-8862803","source":"CTD"},{"inference_gene_symbol":"SOD2","pathway_name":"Neurodegenerative Diseases","react_pathway_id":"R-HSA-8863678","source":"CTD"}]},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:3963","DOID:50","DOID:170","DOID:4","DOID:162","DOID:305","DOID:0050687","DOID:7","DOID:14566","DOID:28","DOID:1781","DOID:0050686"],"children":[],"def":"\"A thyroid gland carcinoma that is composed of undifferentiated cells.\" [url:https\\://www.ncbi.nlm.nih.gov/pubmed/28707679]","descendants":[],"doid":"DOID:0080522","name":"anaplastic thyroid carcinoma","parents":["DOID:3963"],"synonyms":{"exact":["thyroid gland anaplastic carcinoma"]},"xrefs":{"ncit":"C3878"}},"hpo":{"disease_name":"Anaplastic thyroid carcinoma","orphanet":"142","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040280","hpo_id":"HP:0011779","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0000475","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0000853","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0001609","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0005994","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001605","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002015","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002098","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002716","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002781","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0004894","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0012531","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0100526","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001618","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001824","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002094","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002105","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0010307","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0010622","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0011805","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0012735","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0002575","orphanet_refs":"orphanet:142"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0100836","orphanet_refs":"orphanet:142"}]},"mondo":{"ancestors":["MONDO:0000001","MONDO:0045024","MONDO:0004992","MONDO:0015074","MONDO:0005232","MONDO:0002108","MONDO:7770008","MONDO:0021069","MONDO:0005617","MONDO:0015075","MONDO:0005070","MONDO:0003240","MONDO:7770006","MONDO:0005151","MONDO:0023370","MONDO:0005626","MONDO:0002082","MONDO:0004993","MONDO:0700096"],"definition":"A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive. [NCIT:C3878]","label":"thyroid gland undifferentiated (anaplastic) carcinoma","mondo":"MONDO:0006468","parents":["MONDO:0005232","MONDO:0005617","MONDO:0015075"],"synonym":{"exact":["anaplastic carcinoma of the thyroid","anaplastic carcinoma of the thyroid gland","anaplastic carcinoma of thyroid","anaplastic carcinoma of thyroid gland","anaplastic thyroid cancer","anaplastic thyroid carcinoma","anaplastic thyroid gland carcinoma","Dedifferentiated thyroid gland carcinoma","metaplastic thyroid gland carcinoma","pleomorphic thyroid gland carcinoma","sarcomatoid thyroid gland carcinoma","thyroid gland carcinosarcoma","thyroid gland undifferentiated (anaplastic) carcinoma","thyroid gland undifferentiated carcinoma","undifferentiated (anaplastic) thyroid gland cancer","undifferentiated (anaplastic) thyroid gland carcinoma","undifferentiated carcinoma of the thyroid","undifferentiated carcinoma of the thyroid gland","undifferentiated carcinoma of thyroid","undifferentiated carcinoma of thyroid gland","undifferentiated thyroid carcinoma","undifferentiated thyroid gland carcinoma","undifferentiated thyroid tumor","undifferentiated thyroid tumour"],"related":["THAP","thyroid cancer, anaplastic","thyroid carcinoma, anaplastic"]},"xrefs":{"doid":["DOID:0080522"],"efo":["EFO:1000595"],"gard":["0000664"],"hp":["HP:0011779"],"icd11":["foundation:320540024"],"meddra":["10002240"],"medgen":["116064"],"mesh":["D065646"],"ncit":["C3878"],"oncotree":["THAP"],"orphanet":["142"],"sctid":["255031003"],"umls":["C0238461"]}},"original_id":"orphanet:142","umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"non-preferred":"D065646","preferred":"D065646"},"nci":{"non-preferred":"C3878","preferred":"C3878"},"snomed":{"non-preferred":"255031003","preferred":"255031003"},"umls":"C0238461"}}