{"_id":"MONDO:0005893","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"83150-76-9","chemical_name":"Octreotide","direct_evidence":"therapeutic","mesh_chemical_id":"D015282","pubmed":"2319110","source":"CTD"},{"cas_registry_number":"18883-66-4","chemical_name":"Streptozocin","direct_evidence":"therapeutic","mesh_chemical_id":"D013311","pubmed":["185926","186169","2827466","4261143","4352784"],"source":"CTD"}],"mesh":"D018273"},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:1793","DOID:26","DOID:170","DOID:1799","DOID:4","DOID:162","DOID:7","DOID:14566","DOID:28","DOID:0050686"],"children":[],"def":"\"An islet cell tumor that has_material_basis_in epithelial cells.\" [url:http\\://en.wikipedia.org/wiki/Carcinoma]","descendants":[],"doid":"DOID:1798","name":"pancreatic endocrine carcinoma","parents":["DOID:1799"],"synonyms":{"exact":["carcinoma of endocrine pancreas","Islet cell carcinoma","malignant neoplasm of islets of Langerhans","pancreatic neuroendocrine carcinoma"]},"xrefs":{"gard":"13034","icd10":"C25.4","icd9":"157.4","mesh":"D018273","ncit":"C3770","snomedct_us_2025_09_01":"187794005","umls_cui":"C1328479"}},"mondo":{"ancestors":["MONDO:0024503","MONDO:0019496","MONDO:0004335","MONDO:0002120","MONDO:0000001","MONDO:0045024","MONDO:0005815","MONDO:0002516","MONDO:0004992","MONDO:0006181","MONDO:0021223","MONDO:0001933","MONDO:0021040","MONDO:7770008","MONDO:0021069","MONDO:0005070","MONDO:7770006","MONDO:0005151","MONDO:0005626","MONDO:0023370","MONDO:0009831","MONDO:0002082","MONDO:0002356","MONDO:0004993","MONDO:0700096"],"children":["MONDO:0006347","MONDO:0006348"],"definition":"An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. [NCIT:C3770]","descendants":["MONDO:0006348","MONDO:0006347"],"label":"pancreatic endocrine carcinoma","mondo":"MONDO:0005893","parents":["MONDO:0002120","MONDO:0005815","MONDO:0006181","MONDO:0009831"],"synonym":{"exact":["carcinoma of endocrine pancreas","carcinoma, islet cell, malignant","endocrine pancreas carcinoma","high grade pancreatic neuroendocrine carcinoma","high-grade pancreatic neuroendocrine carcinoma","islet cell cancer","islet cell carcinoma","islet cell carcinoma (morphologic abnormality)","malignant islet cell tumor","malignant islet cell tumour","malignant neoplasm of islets of Langerhans","malignant pancreatic endocrine tumor","malignant pancreatic endocrine tumour","pancreatic endocrine cancer","pancreatic endocrine carcinoma","pancreatic NEC","pancreatic NEC G3","Pancreatic Neuroendocrine cancer","pancreatic neuroendocrine carcinoma","poorly differentiated pancreatic endocrine carcinoma","poorly-differentiated NEN of pancreas","poorly-differentiated neuroendocrine neoplasm of pancreas","poorly-differentiated pancreatic NEN","poorly-differentiated pancreatic neuroendocrine neoplasm"]},"xrefs":{"doid":["DOID:1798"],"efo":["EFO:0007416"],"gard":["0022056"],"icd10cm":["C25.4"],"icd9":["157.4"],"icdo":["8150/3"],"medgen":["233070"],"mesh":["D018273"],"ncit":["C3770"],"orphanet":["506098"],"sctid":["254612002"],"umls":["C1328479"]}},"umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10am":{"non-preferred":"M8150/3"},"icd10cm":{"preferred":"C25.4"},"icd9cm":{"non-preferred":"157.4","preferred":"157.4"},"mesh":{"non-preferred":"D018273"},"nci":{"non-preferred":"C3770"},"snomed":{"non-preferred":["60346004","187794005"],"preferred":["93843007","187794005"]},"umls":"C1328479"}}