{"_id":"MONDO:0005817","_version":1,"ctd":{"chemical_related_to_disease":{"cas_registry_number":"59-05-2","chemical_name":"Methotrexate","direct_evidence":"marker/mechanism","mesh_chemical_id":"D008727","pubmed":"11992760","source":"CTD"},"mesh":"D020232"},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:150","DOID:4","DOID:10937"],"children":[],"def":"\"An impulse control disorder that involves abnormalities in memory, social and sexual functioning and idiosyncratic behaviors resulting from damage from trauma or infection to both temporal lobes causing individuals to put objects in their mouths and engage in inappropriate sexual behavior.\" [url:http\\://en.wikipedia.org/wiki/Kl%C3%BCver%E2%80%93Bucy_syndrome, url:http\\://www.ninds.nih.gov/disorders/kluver_bucy/kluver_bucy.htm]","descendants":[],"doid":"DOID:2510","name":"Kluver-Bucy syndrome","parents":["DOID:10937"],"synonyms":{"exact":["Klver-Bucy syndrome"]},"xrefs":{"mesh":"D020232","ncit":"C84802","snomedct_us_2025_09_01":"10651001","umls_cui":"C0270707"}},"mondo":{"ancestors":["MONDO:0005560","MONDO:0005156","MONDO:0000001","MONDO:0002602","MONDO:7770007","MONDO:0020683","MONDO:7770010","MONDO:0020010","MONDO:0005550","MONDO:7770008","MONDO:0001162","MONDO:0005071","MONDO:0024619","MONDO:7770006","MONDO:0700096","MONDO:0021166","MONDO:0002025","MONDO:0019956","MONDO:0020067","MONDO:0002254"],"definition":"Kluver Bucy syndrome is a rare behavioral impairment characterized by inappropriate sexual behaviors and mouthing of objects. Other signs and symptoms include diminished ability to visually recognize objects,loss of normal fear and anger responses, memory loss, distractibility, seizures, and dementia. It is associated with damage to the anterior temporal lobes of the brain. Cases have been reported in association with herpes encephalitis and head trauma. Treatment is symptomatic and may include the use of psychotropic medications. [https://rarediseases.info.nih.gov/diseases/6840/kluver-bucy-syndrome]","excluded_subClassOf":{"mondo":["MONDO:0005084"]},"label":"Kluver-Bucy syndrome","mondo":"MONDO:0005817","parents":["MONDO:0001162","MONDO:0002254","MONDO:0020067"],"synonym":{"exact":["KLüver-Bucy syndrome"],"related":["bilateral temporal lobe disorder","Kluver Bucy syndrome","memory loss, extreme sexual behavior, placidity, and visual distractibility","post-encephalitic Kluver Bucy syndrome (type)","post-traumatic Kluver Bucy syndrome (type)","syndrome, Kluver-Bucy","temporal lobectomy behavior syndrome","temporal lobectomy behaviour syndrome"]},"xrefs":{"doid":["DOID:2510"],"efo":["EFO:0007335"],"gard":["0006840"],"meddra":["10066431"],"medgen":["124361"],"mesh":["D020232"],"ncit":["C84802"],"nord":["1338"],"orphanet":["157823"],"sctid":["10651001"],"umls":["C0270707"]}},"original_id":["UMLS:C0270707","UMLS:C1741120"],"umls":[{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"preferred":"D020232"},"nci":{"preferred":"C84802"},"snomed":{"preferred":"10651001"},"umls":"C0270707"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"preferred":"D020232"},"snomed":{"non-preferred":"10651001","preferred":"10651001"},"umls":"C1741120"}]}