{"_id":"MONDO:0005789","_version":1,"ctd":{"chemical_related_to_disease":{"chemical_name":"Hepatitis B Surface Antigens","direct_evidence":"marker/mechanism","mesh_chemical_id":"D006514","pubmed":"16641257","source":"CTD"},"mesh":"D003699"},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:77","DOID:934","DOID:3118","DOID:4","DOID:409","DOID:7","DOID:2237","DOID:0050117","DOID:1884"],"children":[],"def":"\"A viral hepatitis that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus (Orthohepadnavirus hominoidei). The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma. Hepatitis delta virus, also known as Hepatitis D virus, is not a single viral species but a group of viruses from the genus Deltavirus including Deltavirus italiense, Deltavirus japanense, Deltavirus peruense, Deltavirus taiwanense, Deltavirus togense, Deltavirus carense, Deltavirus cameroonense, Deltavirus senegalense.\" [url:https\\://en.wikipedia.org/wiki/Hepatitis_D, url:https\\://www.cdc.gov/hepatitis-d/about/index.html, url:https\\://www.ncbi.nlm.nih.gov/books/NBK470436/, url:https\\://www.who.int/news-room/fact-sheets/detail/hepatitis-d]","descendants":[],"doid":"DOID:2047","name":"hepatitis D","parents":["DOID:1884"],"synonyms":{"exact":["delta hepatitis"]},"xrefs":{"mesh":"D003699","snomedct_us_2025_09_01":"424460009","umls_cui":"C0011226"}},"hpo":{"disease_name":"Hepatitis delta","orphanet":"402823","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001394","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0012115","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0031964","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000952","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000978","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001289","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001399","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001892","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001945","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002017","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002027","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002039","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0004396","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0004787","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0012378","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0031956","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0033834","orphanet_refs":"orphanet:402823"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001402","orphanet_refs":"orphanet:402823"}]},"mondo":{"MONDO:0100332":{"ncbitaxon":["NCBITaxon:12475"]},"ancestors":["MONDO:0004335","MONDO:0002251","MONDO:0000001","MONDO:0021669","MONDO:7770007","MONDO:0006011","MONDO:0005154","MONDO:7770010","MONDO:0005550","MONDO:7770008","MONDO:0002515","MONDO:0005108","MONDO:7770006","MONDO:0005151","MONDO:0700096","MONDO:0021166","MONDO:0043424","MONDO:0100329","MONDO:0021674"],"definition":"Inflammation of the liver in humans caused by hepatitis delta virus, a defective RNA virus that can only infect hepatitis B patients. For its viral coating, hepatitis delta virus requires the hepatitis B surface antigens produced by these patients. Hepatitis D can occur either concomitantly with (coinfection) or subsequent to (superinfection) hepatitis B infection. Similar to hepatitis B, it is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. [MESH:D003699]","disease_arises_from_feature":{"mondo":["MONDO:0005344"]},"disease_has_infectious_agent":{"ncbitaxon":["NCBITaxon:10407"]},"label":"hepatitis D virus infection","mondo":"MONDO:0005789","parents":["MONDO:0006011","MONDO:0021674"],"synonym":{"exact":["HDV","Hepatitis D","Hepatitis D virus","hepatitis delta","Hepatitis delta virus caused hepatitis","Hepatitis delta virus hepatitis","hepatitis type D"]},"xrefs":{"doid":["DOID:2047"],"efo":["EFO:0007304"],"gard":["0021716"],"icd9":["070.52"],"medgen":["4182"],"mesh":["D003699"],"nord":["2020"],"orphanet":["402823"],"sctid":["707341005"],"umls":["C0011226"]}},"original_id":"orphanet:402823","umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"non-preferred":"D003699"},"snomed":{"non-preferred":"707341005","preferred":"424460009"},"umls":"C0011226"}}