{"_id":"MONDO:0005744","_version":1,"ctd":{"chemical_related_to_disease":{"chemical_name":"PVB protocol","direct_evidence":"therapeutic","mesh_chemical_id":"C034483","pubmed":"17048439","source":"CTD"},"mesh":"D018240","pathway_related_to_disease":[{"inference_gene_symbol":"TNFSF8","kegg_pathway_id":"hsa04060","pathway_name":"Cytokine-cytokine receptor interaction","source":"CTD"},{"inference_gene_symbol":"TNFSF8","pathway_name":"Cytokine Signaling in Immune system","react_pathway_id":"R-HSA-1280215","source":"CTD"},{"inference_gene_symbol":"TNFSF8","pathway_name":"Immune System","react_pathway_id":"R-HSA-168256","source":"CTD"},{"inference_gene_symbol":"TNFSF8","pathway_name":"TNFR2 non-canonical NF-kB pathway","react_pathway_id":"R-HSA-5668541","source":"CTD"},{"inference_gene_symbol":"TNFSF8","pathway_name":"TNFs bind their physiological receptors","react_pathway_id":"R-HSA-5669034","source":"CTD"}]},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:4","DOID:14566","DOID:2994","DOID:0050687","DOID:162"],"children":["DOID:5342","DOID:5348"],"def":"\"A germ cell cancer that has_material_basis_in cells that line the yolk sac of the embryo.\" [url:http\\://en.wikipedia.org/wiki/Endodermal_sinus_tumor, url:http\\://en.wikipedia.org/wiki/Germ_cell_tumor, url:http\\://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=876, url:https\\://www.cincinnatichildrens.org/health/y/yolk-sac/]","descendants":["DOID:5348","DOID:5342"],"doid":"DOID:1911","name":"endodermal sinus tumor","parents":["DOID:2994"],"synonyms":{"exact":["endodermal sinus tumour","Hepatoid yolk sac tumour","infantile embryonal carcinoma","Yolk Sac neoplasm","yolk sac tumor","Yolk sac tumour"]},"xrefs":{"icdo":"9071/3","mesh":"D018240","ncit":"C3011","snomedct_us_2025_09_01":"74409009","umls_cui":"C0014145"}},"mondo":{"ancestors":["MONDO:0005040","MONDO:0018201","MONDO:0000001","MONDO:0045024","MONDO:0020539","MONDO:0004992","MONDO:0003578","MONDO:0006290","MONDO:7770008","MONDO:0021656","MONDO:0005070","MONDO:0003113","MONDO:0023370","MONDO:0700096"],"children":["MONDO:0002143","MONDO:0003400","MONDO:0003402","MONDO:0003404","MONDO:0006344","MONDO:0016739","MONDO:0023726"],"definition":"A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum. [NCIT:P378]","descendants":["MONDO:0003402","MONDO:0003905","MONDO:0004494","MONDO:0004547","MONDO:0006344","MONDO:0003401","MONDO:0004402","MONDO:0004453","MONDO:0003759","MONDO:0016739","MONDO:0004198","MONDO:0003400","MONDO:0003907","MONDO:0003906","MONDO:0003399","MONDO:0004543","MONDO:0004493","MONDO:0004178","MONDO:0004219","MONDO:0002143","MONDO:0023726","MONDO:0004106","MONDO:0003404"],"label":"yolk sac tumor","mondo":"MONDO:0005744","parents":["MONDO:0003578"],"synonym":{"exact":["endodermal sinus neoplasm","endodermal sinus tumor","hepatoid yolk sac tumor","yolk Sac neoplasm","yolk Sac tumor","yolk sac tumor","yolk Sac tumor site unspecified","yolk SAC tumor, malignant","yolk Sac tumour site unspecified"]},"xrefs":{"doid":["DOID:1911"],"efo":["EFO:0007252"],"gard":["0000348"],"icdo":["9071/3"],"meddra":["10048251"],"medgen":["41782"],"nando":["2200069"],"ncit":["C3011"],"oncotree":["BYST"],"orphanet":["876"],"sctid":["404081005"],"umls":["C0014145"]}},"original_id":"MESH:D018240","umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10am":{"non-preferred":"M9071/3"},"mesh":{"non-preferred":"D018240","preferred":"D018240"},"nci":{"non-preferred":"C3011","preferred":"C3011"},"snomed":{"non-preferred":["74409009","404081005"],"preferred":["74409009","404081005"]},"umls":"C0014145"}}