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The infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding.\" [url:https\\://www.cdc.gov/dengue/about/index.html, url:https\\://www.merriam-webster.com/dictionary/dengue#medicalDictionary, url:https\\://www.ncbi.nlm.nih.gov/books/NBK430732/]","descendants":["DOID:0050143","DOID:0050125","DOID:12206"],"doid":"DOID:12205","name":"dengue disease","parents":["DOID:934"],"synonyms":{"exact":["breakbone fever","classic dengue","Dengue Fever"],"related":["classical dengue"]},"xrefs":{"gard":"6254","icd10":"A90","icd9":"061","mesh":"D003715","ncit":"C34528","snomedct_us_2025_09_01":"38362002","umls_cui":"C0011311"}},"hpo":{"disease_name":"Dengue fever","orphanet":"99828","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000225","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000421","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000967","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000978","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000988","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000989","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001254","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001342","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001541","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001873","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001882","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0001945","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002014","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002017","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002027","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002239","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002240","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0002315","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002615","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002829","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0003075","orphanet_refs":"orphanet:99828"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0006543","orphanet_refs":"orphanet:99828"}]},"mondo":{"MONDO:0100332":{"ncbitaxon":["NCBITaxon:12637"]},"ancestors":["MONDO:0700096","MONDO:0000001","MONDO:7770010","MONDO:0005763","MONDO:0005108","MONDO:0005550","MONDO:0100329","MONDO:0100120","MONDO:7770008"],"children":["MONDO:0000259","MONDO:0005358"],"definition":"Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS). 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