{"_id":"MONDO:0005072","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"106-99-0","chemical_name":"1,3-butadiene","direct_evidence":"marker/mechanism","mesh_chemical_id":"C031763","pubmed":"15814359","source":"CTD"},{"cas_registry_number":"77679-27-7","chemical_name":"3-Iodobenzylguanidine","direct_evidence":"therapeutic","mesh_chemical_id":"D019797","pubmed":"27515310","source":"CTD"},{"chemical_name":"4-oxofenretinide","direct_evidence":"therapeutic","mesh_chemical_id":"C494898","pubmed":"16540676","source":"CTD"},{"chemical_name":"9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one","direct_evidence":"therapeutic","mesh_chemical_id":"C558529","pubmed":"22789543","source":"CTD"},{"chemical_name":"ABT-737","direct_evidence":"therapeutic","mesh_chemical_id":"C501332","pubmed":"23341456","source":"CTD"},{"cas_registry_number":"494-38-2","chemical_name":"Acridine Orange","direct_evidence":"therapeutic","mesh_chemical_id":"D000165","pubmed":"16814760","source":"CTD"},{"cas_registry_number":"1327-53-3","chemical_name":"Arsenic Trioxide","direct_evidence":"therapeutic","mesh_chemical_id":"D000077237","pubmed":["10428472","10721769","11027660"],"source":"CTD"},{"cas_registry_number":"80-05-7","chemical_name":"bisphenol A","direct_evidence":"marker/mechanism","mesh_chemical_id":"C006780","pubmed":"27366082","source":"CTD"},{"chemical_name":"Bortezomib","direct_evidence":"therapeutic","mesh_chemical_id":"D000069286","pubmed":"18534018","source":"CTD"},{"cas_registry_number":"55-98-1","chemical_name":"Busulfan","direct_evidence":"therapeutic","mesh_chemical_id":"D002066","pubmed":"14595385","source":"CTD"},{"cas_registry_number":"41575-94-4","chemical_name":"Carboplatin","direct_evidence":"therapeutic","mesh_chemical_id":"D016190","pubmed":"15768383","source":"CTD"},{"chemical_name":"Celecoxib","direct_evidence":"therapeutic","mesh_chemical_id":"D000068579","pubmed":"15492235","source":"CTD"},{"cas_registry_number":"15663-27-1","chemical_name":"Cisplatin","direct_evidence":"therapeutic","mesh_chemical_id":"D002945","pubmed":["18353067","2206854","3335892","3813490","8761367"],"source":"CTD"},{"chemical_name":"Crizotinib","direct_evidence":"therapeutic","mesh_chemical_id":"D000077547","pubmed":["22266870","22588779","22789543"],"source":"CTD"},{"cas_registry_number":"50-18-0","chemical_name":"Cyclophosphamide","direct_evidence":"therapeutic","mesh_chemical_id":"D003520","pubmed":["15176712","16115947","18353067","3688893","476599","857581","8761367"],"source":"CTD"},{"cas_registry_number":"4342-03-4","chemical_name":"Dacarbazine","direct_evidence":"therapeutic","mesh_chemical_id":"D003606","pubmed":["3688893","857581"],"source":"CTD"},{"cas_registry_number":"2353-33-5","chemical_name":"Decitabine","direct_evidence":"therapeutic","mesh_chemical_id":"D000077209","pubmed":"7507741","source":"CTD"},{"cas_registry_number":"69222-20-4","chemical_name":"deoxypodophyllotoxin","direct_evidence":"therapeutic","mesh_chemical_id":"C014451","pubmed":"31255282","source":"CTD"},{"cas_registry_number":"15307-86-5","chemical_name":"Diclofenac","direct_evidence":"therapeutic","mesh_chemical_id":"D004008","pubmed":"15492235","source":"CTD"},{"cas_registry_number":"23214-92-8","chemical_name":"Doxorubicin","direct_evidence":"therapeutic","mesh_chemical_id":"D004317","pubmed":["15555623","18353067"],"source":"CTD"},{"cas_registry_number":"33419-42-0","chemical_name":"Etoposide","direct_evidence":"therapeutic","mesh_chemical_id":"D005047","pubmed":["15768383","18353067","3335892","3813490"],"source":"CTD"},{"cas_registry_number":"129453-61-8","chemical_name":"Fulvestrant","direct_evidence":"therapeutic","mesh_chemical_id":"D000077267","pubmed":"27366082","source":"CTD"},{"chemical_name":"ICE protocol 1","direct_evidence":"therapeutic","mesh_chemical_id":"C056638","pubmed":"15176712","source":"CTD"},{"chemical_name":"ICE protocol 3","direct_evidence":"therapeutic","mesh_chemical_id":"C080042","pubmed":"8913079","source":"CTD"},{"cas_registry_number":"3778-73-2","chemical_name":"Ifosfamide","direct_evidence":"therapeutic","mesh_chemical_id":"D007069","pubmed":["2910509","3688893","3819813"],"source":"CTD"},{"chemical_name":"Irinotecan","direct_evidence":"therapeutic","mesh_chemical_id":"D000077146","pubmed":"8761367","source":"CTD"},{"cas_registry_number":"1909-91-7","chemical_name":"isocupressic acid","direct_evidence":"therapeutic","mesh_chemical_id":"C110793","pubmed":"31255282","source":"CTD"},{"cas_registry_number":"4759-48-2","chemical_name":"Isotretinoin","direct_evidence":"therapeutic","mesh_chemical_id":"D015474","pubmed":["17368321","18353067","18839433","19492317","7707116","8214363"],"source":"CTD"},{"chemical_name":"JET protocol","direct_evidence":"therapeutic","mesh_chemical_id":"C066308","pubmed":"2206854","source":"CTD"},{"chemical_name":"(+)-JQ1 compound","direct_evidence":"therapeutic","mesh_chemical_id":"C561695","pubmed":"23430699","source":"CTD"},{"chemical_name":"licochalcone E","direct_evidence":"therapeutic","mesh_chemical_id":"C520147","pubmed":"35092341","source":"CTD"},{"cas_registry_number":"580-72-3","chemical_name":"matairesinol","direct_evidence":"therapeutic","mesh_chemical_id":"C068935","pubmed":"31255282","source":"CTD"},{"cas_registry_number":"148-82-3","chemical_name":"Melphalan","direct_evidence":"therapeutic","mesh_chemical_id":"D008558","pubmed":["14595385","18353067","2327660"],"source":"CTD"},{"cas_registry_number":"19767-45-4","chemical_name":"Mesna","direct_evidence":"therapeutic","mesh_chemical_id":"D015080","pubmed":"3819813","source":"CTD"},{"chemical_name":"MLN 8237","direct_evidence":"therapeutic","mesh_chemical_id":"C550258","pubmed":"22588779","source":"CTD"},{"cas_registry_number":"25154-52-3","chemical_name":"nonylphenol","direct_evidence":"marker/mechanism","mesh_chemical_id":"C025256","pubmed":"27366082","source":"CTD"},{"chemical_name":"nutlin 3","direct_evidence":"therapeutic","mesh_chemical_id":"C482205","pubmed":"22260869","source":"CTD"},{"chemical_name":"NVP-TAE684","direct_evidence":"therapeutic","mesh_chemical_id":"C516714","pubmed":"22588779","source":"CTD"},{"chemical_name":"OC-HDP protocol","direct_evidence":"therapeutic","mesh_chemical_id":"C051760","pubmed":"3561328","source":"CTD"},{"chemical_name":"OPEC OJEC protocol","direct_evidence":"therapeutic","mesh_chemical_id":"C432684","pubmed":["11464894","21214410"],"source":"CTD"},{"cas_registry_number":"57-41-0","chemical_name":"Phenytoin","direct_evidence":"marker/mechanism","mesh_chemical_id":"D010672","pubmed":"1623454","source":"CTD"},{"cas_registry_number":"7440-06-4","chemical_name":"Platinum","direct_evidence":"therapeutic","mesh_chemical_id":"D010984","pubmed":"16814760","source":"CTD"},{"chemical_name":"Platinum Compounds","direct_evidence":"therapeutic","mesh_chemical_id":"D017671","pubmed":["16314621","16814760"],"source":"CTD"},{"chemical_name":"Resveratrol","direct_evidence":"therapeutic","mesh_chemical_id":"D000077185","pubmed":"37482209","source":"CTD"},{"cas_registry_number":"85622-93-1","chemical_name":"Temozolomide","direct_evidence":"therapeutic","mesh_chemical_id":"D000077204","pubmed":"15176712","source":"CTD"},{"cas_registry_number":"52-24-4","chemical_name":"Thiotepa","direct_evidence":"therapeutic","mesh_chemical_id":"D013852","pubmed":"8761367","source":"CTD"},{"cas_registry_number":"123948-87-8","chemical_name":"Topotecan","direct_evidence":"therapeutic","mesh_chemical_id":"D019772","pubmed":"15176712","source":"CTD"},{"cas_registry_number":"97322-87-7","chemical_name":"Troglitazone","direct_evidence":"therapeutic","mesh_chemical_id":"D000077288","pubmed":"16820965","source":"CTD"},{"cas_registry_number":"13220-57-0","chemical_name":"tryptanthrine","direct_evidence":"therapeutic","mesh_chemical_id":"C046243","pubmed":"23500671","source":"CTD"},{"chemical_name":"Vincristine","direct_evidence":"therapeutic","mesh_chemical_id":"D014750","pubmed":["18353067","4294312","857581"],"source":"CTD"},{"cas_registry_number":"53643-48-4","chemical_name":"Vindesine","direct_evidence":"therapeutic","mesh_chemical_id":"D014751","pubmed":["7038420","7438126"],"source":"CTD"},{"chemical_name":"WP 744","direct_evidence":"therapeutic","mesh_chemical_id":"C451735","pubmed":"15555623","source":"CTD"}],"mesh":"D009447","pathway_related_to_disease":[{"inference_gene_symbol":"COX2","kegg_pathway_id":"hsa00190","pathway_name":"Oxidative phosphorylation","source":"CTD"},{"inference_gene_symbol":"NT5E","kegg_pathway_id":"hsa00230","pathway_name":"Purine metabolism","source":"CTD"},{"inference_gene_symbol":"NT5E","kegg_pathway_id":"hsa00240","pathway_name":"Pyrimidine metabolism","source":"CTD"},{"inference_gene_symbol":["DBH","TH"],"kegg_pathway_id":"hsa00350","pathway_name":"Tyrosine metabolism","source":"CTD"},{"inference_gene_symbol":"NT5E","kegg_pathway_id":"hsa00760","pathway_name":"Nicotinate and nicotinamide metabolism","source":"CTD"},{"inference_gene_symbol":["COX2","DBH","NT5E","TH"],"kegg_pathway_id":"hsa01100","pathway_name":"Metabolic pathways","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS"],"kegg_pathway_id":"hsa01521","pathway_name":"EGFR tyrosine kinase inhibitor resistance","source":"CTD"},{"inference_gene_symbol":["CDKN2A","ESR1","GNAS","HRAS","KRAS","MMP9","NRAS"],"kegg_pathway_id":"hsa01522","pathway_name":"Endocrine resistance","source":"CTD"},{"inference_gene_symbol":["IL1B","RELA","TNF"],"kegg_pathway_id":"hsa01523","pathway_name":"Antifolate resistance","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","CDKN2A"],"kegg_pathway_id":"hsa01524","pathway_name":"Platinum drug resistance","source":"CTD"},{"inference_gene_symbol":"ABCB1","kegg_pathway_id":"hsa02010","pathway_name":"ABC transporters","source":"CTD"},{"inference_gene_symbol":"PSMD14","kegg_pathway_id":"hsa03050","pathway_name":"Proteasome","source":"CTD"},{"inference_gene_symbol":"BARD1","kegg_pathway_id":"hsa03440","pathway_name":"Homologous recombination","source":"CTD"},{"inference_gene_symbol":["HRAS","IL1B","KRAS","MYC","NRAS","NTRK1","NTRK2","RELA","TNF"],"kegg_pathway_id":"hsa04010","pathway_name":"MAPK signaling pathway","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","MYC","NRAS","PAK4"],"kegg_pathway_id":"hsa04012","pathway_name":"ErbB signaling pathway","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PAK4","PTPN11","RASSF5","RELA"],"kegg_pathway_id":"hsa04014","pathway_name":"Ras signaling pathway","source":"CTD"},{"inference_gene_symbol":["GNAS","HGF","HRAS","KRAS","MET","NRAS","RASSF5"],"kegg_pathway_id":"hsa04015","pathway_name":"Rap1 signaling pathway","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04020","pathway_name":"Calcium signaling pathway","source":"CTD"},{"inference_gene_symbol":["GNAS","RELA"],"kegg_pathway_id":"hsa04024","pathway_name":"cAMP signaling pathway","source":"CTD"},{"inference_gene_symbol":["HGF","IFNB1","IL1B","MET","TNF","TNFSF10"],"kegg_pathway_id":"hsa04060","pathway_name":"Cytokine-cytokine receptor interaction","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","RELA"],"kegg_pathway_id":"hsa04062","pathway_name":"Chemokine signaling pathway","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","IL1B","RELA","TNF"],"kegg_pathway_id":"hsa04064","pathway_name":"NF-kappa B signaling pathway","source":"CTD"},{"inference_gene_symbol":"RELA","kegg_pathway_id":"hsa04066","pathway_name":"HIF-1 signaling pathway","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","TNFSF10"],"kegg_pathway_id":"hsa04068","pathway_name":"FoxO signaling pathway","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","RELA","TNF"],"kegg_pathway_id":"hsa04071","pathway_name":"Sphingolipid signaling pathway","source":"CTD"},{"inference_gene_symbol":["GNAS","HRAS","KRAS","NRAS","PTPN11"],"kegg_pathway_id":"hsa04072","pathway_name":"Phospholipase D signaling pathway","source":"CTD"},{"inference_gene_symbol":["CDKN2A","CHEK2","MYC"],"kegg_pathway_id":"hsa04110","pathway_name":"Cell cycle","source":"CTD"},{"inference_gene_symbol":"AURKA","kegg_pathway_id":"hsa04114","pathway_name":"Oocyte meiosis","source":"CTD"},{"inference_gene_symbol":["CDKN2A","CHEK2"],"kegg_pathway_id":"hsa04115","pathway_name":"p53 signaling pathway","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3"],"kegg_pathway_id":"hsa04120","pathway_name":"Ubiquitin mediated proteolysis","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PINK1","RELA"],"kegg_pathway_id":"hsa04137","pathway_name":"Mitophagy - animal","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04140","pathway_name":"Autophagy - animal","source":"CTD"},{"inference_gene_symbol":["HRAS","MET","NTRK1"],"kegg_pathway_id":"hsa04144","pathway_name":"Endocytosis","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","TNF"],"kegg_pathway_id":"hsa04150","pathway_name":"mTOR signaling pathway","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","IFNB1","KRAS","MET","MYB","MYC","NRAS","RELA"],"kegg_pathway_id":"hsa04151","pathway_name":"PI3K-Akt signaling pathway","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","HRAS","KRAS","NRAS","NTRK1","RELA","TNF","TNFSF10"],"kegg_pathway_id":"hsa04210","pathway_name":"Apoptosis","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","RELA"],"kegg_pathway_id":"hsa04211","pathway_name":"Longevity regulating pathway","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04213","pathway_name":"Longevity regulating pathway - multiple species","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3"],"kegg_pathway_id":"hsa04215","pathway_name":"Apoptosis - multiple species","source":"CTD"},{"inference_gene_symbol":"COX2","kegg_pathway_id":"hsa04260","pathway_name":"Cardiac muscle contraction","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04261","pathway_name":"Adrenergic signaling in cardiomyocytes","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04270","pathway_name":"Vascular smooth muscle contraction","source":"CTD"},{"inference_gene_symbol":"MYC","kegg_pathway_id":"hsa04310","pathway_name":"Wnt signaling pathway","source":"CTD"},{"inference_gene_symbol":"KRAS","kegg_pathway_id":"hsa04320","pathway_name":"Dorso-ventral axis formation","source":"CTD"},{"inference_gene_symbol":["MYC","TNF"],"kegg_pathway_id":"hsa04350","pathway_name":"TGF-beta signaling pathway","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","MET","NRAS","PAK4","PTPN11","SEMA3B"],"kegg_pathway_id":"hsa04360","pathway_name":"Axon guidance","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04370","pathway_name":"VEGF signaling pathway","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04371","pathway_name":"Apelin signaling pathway","source":"CTD"},{"inference_gene_symbol":["IFNB1","IL1B","RELA","TNF"],"kegg_pathway_id":"hsa04380","pathway_name":"Osteoclast differentiation","source":"CTD"},{"inference_gene_symbol":["BIRC2","MYC","YAP1"],"kegg_pathway_id":"hsa04390","pathway_name":"Hippo signaling pathway","source":"CTD"},{"inference_gene_symbol":"YAP1","kegg_pathway_id":"hsa04392","pathway_name":"Hippo signaling pathway -multiple species","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","HGF","HRAS","MET","PAK4"],"kegg_pathway_id":"hsa04510","pathway_name":"Focal adhesion","source":"CTD"},{"inference_gene_symbol":"CD44","kegg_pathway_id":"hsa04512","pathway_name":"ECM-receptor interaction","source":"CTD"},{"inference_gene_symbol":"MET","kegg_pathway_id":"hsa04520","pathway_name":"Adherens junction","source":"CTD"},{"inference_gene_symbol":["GNAS","HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04540","pathway_name":"Gap junction","source":"CTD"},{"inference_gene_symbol":["HRAS","ISL1","KRAS","MYC","NRAS"],"kegg_pathway_id":"hsa04550","pathway_name":"Signaling pathways regulating pluripotency of stem cells","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04611","pathway_name":"Platelet activation","source":"CTD"},{"inference_gene_symbol":"TNF","kegg_pathway_id":"hsa04612","pathway_name":"Antigen processing and presentation","source":"CTD"},{"inference_gene_symbol":["IFNB1","IL1B","RELA","TNF"],"kegg_pathway_id":"hsa04620","pathway_name":"Toll-like receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","IFNB1","IL1B","RELA","TNF"],"kegg_pathway_id":"hsa04621","pathway_name":"NOD-like receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":["IFNB1","RELA","TNF"],"kegg_pathway_id":"hsa04622","pathway_name":"RIG-I-like receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":["IFNB1","IL1B","RELA"],"kegg_pathway_id":"hsa04623","pathway_name":"Cytosolic DNA-sensing pathway","source":"CTD"},{"inference_gene_symbol":["HRAS","IFNB1","MYC","PTPN11"],"kegg_pathway_id":"hsa04630","pathway_name":"Jak-STAT signaling pathway","source":"CTD"},{"inference_gene_symbol":["CD44","IL1B","TNF"],"kegg_pathway_id":"hsa04640","pathway_name":"Hematopoietic cell lineage","source":"CTD"},{"inference_gene_symbol":["HRAS","IFNB1","KRAS","NRAS","PTPN11","TNF","TNFSF10"],"kegg_pathway_id":"hsa04650","pathway_name":"Natural killer cell mediated cytotoxicity","source":"CTD"},{"inference_gene_symbol":["IL1B","MMP9","RELA","TNF"],"kegg_pathway_id":"hsa04657","pathway_name":"IL-17 signaling pathway","source":"CTD"},{"inference_gene_symbol":["GATA3","RELA"],"kegg_pathway_id":"hsa04658","pathway_name":"Th1 and Th2 cell differentiation","source":"CTD"},{"inference_gene_symbol":["GATA3","IL1B","RELA"],"kegg_pathway_id":"hsa04659","pathway_name":"Th17 cell differentiation","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PAK4","RELA","TNF"],"kegg_pathway_id":"hsa04660","pathway_name":"T cell receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","RELA"],"kegg_pathway_id":"hsa04662","pathway_name":"B cell receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","TNF"],"kegg_pathway_id":"hsa04664","pathway_name":"Fc epsilon RI signaling pathway","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","IL1B","MMP9","RELA","TNF"],"kegg_pathway_id":"hsa04668","pathway_name":"TNF signaling pathway","source":"CTD"},{"inference_gene_symbol":["MMP9","PTPN11","RASSF5"],"kegg_pathway_id":"hsa04670","pathway_name":"Leukocyte transendothelial migration","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04713","pathway_name":"Circadian entrainment","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04720","pathway_name":"Long-term potentiation","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","NTRK1","NTRK2","PTPN11","RELA"],"kegg_pathway_id":"hsa04722","pathway_name":"Neurotrophin signaling pathway","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04724","pathway_name":"Glutamatergic synapse","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04725","pathway_name":"Cholinergic synapse","source":"CTD"},{"inference_gene_symbol":["GNAS","HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04726","pathway_name":"Serotonergic synapse","source":"CTD"},{"inference_gene_symbol":["GNAS","TH"],"kegg_pathway_id":"hsa04728","pathway_name":"Dopaminergic synapse","source":"CTD"},{"inference_gene_symbol":["GNAS","HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04730","pathway_name":"Long-term depression","source":"CTD"},{"inference_gene_symbol":["GNAS","IL1B","NTRK1"],"kegg_pathway_id":"hsa04750","pathway_name":"Inflammatory mediator regulation of TRP channels","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PAK4"],"kegg_pathway_id":"hsa04810","pathway_name":"Regulation of actin cytoskeleton","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04910","pathway_name":"Insulin signaling pathway","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04911","pathway_name":"Insulin secretion","source":"CTD"},{"inference_gene_symbol":["GNAS","HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04912","pathway_name":"GnRH signaling pathway","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04913","pathway_name":"Ovarian steroidogenesis","source":"CTD"},{"inference_gene_symbol":"KRAS","kegg_pathway_id":"hsa04914","pathway_name":"Progesterone-mediated oocyte maturation","source":"CTD"},{"inference_gene_symbol":["ESR1","GNAS","HRAS","KRAS","MMP9","NRAS"],"kegg_pathway_id":"hsa04915","pathway_name":"Estrogen signaling pathway","source":"CTD"},{"inference_gene_symbol":["GNAS","HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04916","pathway_name":"Melanogenesis","source":"CTD"},{"inference_gene_symbol":["ESR1","HRAS","KRAS","NRAS","RELA","TH"],"kegg_pathway_id":"hsa04917","pathway_name":"Prolactin signaling pathway","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04918","pathway_name":"Thyroid hormone synthesis","source":"CTD"},{"inference_gene_symbol":["ESR1","HRAS","KRAS","MYC","NRAS"],"kegg_pathway_id":"hsa04919","pathway_name":"Thyroid hormone signaling pathway","source":"CTD"},{"inference_gene_symbol":["PTPN11","RELA","TNF"],"kegg_pathway_id":"hsa04920","pathway_name":"Adipocytokine signaling pathway","source":"CTD"},{"inference_gene_symbol":["GNAS","HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa04921","pathway_name":"Oxytocin signaling pathway","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04922","pathway_name":"Glucagon signaling pathway","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04923","pathway_name":"Regulation of lipolysis in adipocytes","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04924","pathway_name":"Renin secretion","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04925","pathway_name":"Aldosterone synthesis and secretion","source":"CTD"},{"inference_gene_symbol":"TNF","kegg_pathway_id":"hsa04930","pathway_name":"Type II diabetes mellitus","source":"CTD"},{"inference_gene_symbol":["PTPN11","RELA","TNF"],"kegg_pathway_id":"hsa04931","pathway_name":"Insulin resistance","source":"CTD"},{"inference_gene_symbol":["COX2","IL1B","RELA","TNF"],"kegg_pathway_id":"hsa04932","pathway_name":"Non-alcoholic fatty liver disease (NAFLD)","source":"CTD"},{"inference_gene_symbol":["HRAS","IL1B","KRAS","NRAS","RELA","TNF"],"kegg_pathway_id":"hsa04933","pathway_name":"AGE-RAGE signaling pathway in diabetic complications","source":"CTD"},{"inference_gene_symbol":["IL1B","TNF"],"kegg_pathway_id":"hsa04940","pathway_name":"Type I diabetes mellitus","source":"CTD"},{"inference_gene_symbol":"KRAS","kegg_pathway_id":"hsa04960","pathway_name":"Aldosterone-regulated sodium reabsorption","source":"CTD"},{"inference_gene_symbol":["ESR1","GNAS"],"kegg_pathway_id":"hsa04961","pathway_name":"Endocrine and other factor-regulated calcium reabsorption","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04962","pathway_name":"Vasopressin-regulated water reabsorption","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04970","pathway_name":"Salivary secretion","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04971","pathway_name":"Gastric acid secretion","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa04972","pathway_name":"Pancreatic secretion","source":"CTD"},{"inference_gene_symbol":["ABCB1","GNAS"],"kegg_pathway_id":"hsa04976","pathway_name":"Bile secretion","source":"CTD"},{"inference_gene_symbol":["COX2","IL1B","TNF"],"kegg_pathway_id":"hsa05010","pathway_name":"Alzheimer's disease","source":"CTD"},{"inference_gene_symbol":["COX2","PINK1","TH"],"kegg_pathway_id":"hsa05012","pathway_name":"Parkinson's disease","source":"CTD"},{"inference_gene_symbol":"TNF","kegg_pathway_id":"hsa05014","pathway_name":"Amyotrophic lateral sclerosis (ALS)","source":"CTD"},{"inference_gene_symbol":"COX2","kegg_pathway_id":"hsa05016","pathway_name":"Huntington's disease","source":"CTD"},{"inference_gene_symbol":"IL1B","kegg_pathway_id":"hsa05020","pathway_name":"Prion diseases","source":"CTD"},{"inference_gene_symbol":["GNAS","RELA","TH"],"kegg_pathway_id":"hsa05030","pathway_name":"Cocaine addiction","source":"CTD"},{"inference_gene_symbol":["GNAS","TH"],"kegg_pathway_id":"hsa05031","pathway_name":"Amphetamine addiction","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa05032","pathway_name":"Morphine addiction","source":"CTD"},{"inference_gene_symbol":["GNAS","HRAS","KRAS","NRAS","NTRK2","TH"],"kegg_pathway_id":"hsa05034","pathway_name":"Alcoholism","source":"CTD"},{"inference_gene_symbol":"MET","kegg_pathway_id":"hsa05100","pathway_name":"Bacterial invasion of epithelial cells","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa05110","pathway_name":"Vibrio cholerae infection","source":"CTD"},{"inference_gene_symbol":["MET","PTPN11","RELA"],"kegg_pathway_id":"hsa05120","pathway_name":"Epithelial cell signaling in Helicobacter pylori infection","source":"CTD"},{"inference_gene_symbol":["CD44","RELA"],"kegg_pathway_id":"hsa05131","pathway_name":"Shigellosis","source":"CTD"},{"inference_gene_symbol":["IL1B","RELA"],"kegg_pathway_id":"hsa05132","pathway_name":"Salmonella infection","source":"CTD"},{"inference_gene_symbol":["IL1B","RELA","TNF"],"kegg_pathway_id":"hsa05133","pathway_name":"Pertussis","source":"CTD"},{"inference_gene_symbol":["IL1B","RELA","TNF"],"kegg_pathway_id":"hsa05134","pathway_name":"Legionellosis","source":"CTD"},{"inference_gene_symbol":["IL1B","RELA","TNF"],"kegg_pathway_id":"hsa05140","pathway_name":"Leishmaniasis","source":"CTD"},{"inference_gene_symbol":["GNAS","IFNB1","IL1B","RELA","TNF"],"kegg_pathway_id":"hsa05142","pathway_name":"Chagas disease (American trypanosomiasis)","source":"CTD"},{"inference_gene_symbol":["IL1B","TNF"],"kegg_pathway_id":"hsa05143","pathway_name":"African trypanosomiasis","source":"CTD"},{"inference_gene_symbol":["HGF","IL1B","MET","TNF"],"kegg_pathway_id":"hsa05144","pathway_name":"Malaria","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","RELA","TNF"],"kegg_pathway_id":"hsa05145","pathway_name":"Toxoplasmosis","source":"CTD"},{"inference_gene_symbol":["GNAS","IL1B","RELA","TNF"],"kegg_pathway_id":"hsa05146","pathway_name":"Amoebiasis","source":"CTD"},{"inference_gene_symbol":["IFNB1","IL1B","RELA","TNF"],"kegg_pathway_id":"hsa05152","pathway_name":"Tuberculosis","source":"CTD"},{"inference_gene_symbol":["HRAS","IFNB1","KRAS","NRAS","RELA","TNF"],"kegg_pathway_id":"hsa05160","pathway_name":"Hepatitis C","source":"CTD"},{"inference_gene_symbol":["HRAS","IFNB1","KRAS","MMP9","MYC","NRAS","RELA","TNF"],"kegg_pathway_id":"hsa05161","pathway_name":"Hepatitis B","source":"CTD"},{"inference_gene_symbol":["IFNB1","IL1B","RELA","TNFSF10"],"kegg_pathway_id":"hsa05162","pathway_name":"Measles","source":"CTD"},{"inference_gene_symbol":["IFNB1","IL1B","RELA","TNF","TNFSF10"],"kegg_pathway_id":"hsa05164","pathway_name":"Influenza A","source":"CTD"},{"inference_gene_symbol":["CDKN2A","CHEK2","HRAS","KRAS","MYB","MYC","NRAS","RELA","TERT","TNF"],"kegg_pathway_id":"hsa05166","pathway_name":"HTLV-I infection","source":"CTD"},{"inference_gene_symbol":["IFNB1","IL1B","PTPN11","RELA","TNF"],"kegg_pathway_id":"hsa05168","pathway_name":"Herpes simplex infection","source":"CTD"},{"inference_gene_symbol":["CD44","MYC","PSMD14","RELA"],"kegg_pathway_id":"hsa05169","pathway_name":"Epstein-Barr virus infection","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","CDKN2A","GNAS","HGF","HRAS","KRAS","MET","MMP9","MYC","NRAS","NTRK1","RASSF5","RELA"],"kegg_pathway_id":"hsa05200","pathway_name":"Pathways in cancer","source":"CTD"},{"inference_gene_symbol":["BIRC3","MET","MMP9","MYC","MYCN","NTRK1","RELA"],"kegg_pathway_id":"hsa05202","pathway_name":"Transcriptional misregulation in cancer","source":"CTD"},{"inference_gene_symbol":["CDKN2A","HRAS","KRAS","NRAS","RELA"],"kegg_pathway_id":"hsa05203","pathway_name":"Viral carcinogenesis","source":"CTD"},{"inference_gene_symbol":["CD44","ESR1","HGF","HRAS","KRAS","MET","MMP9","MYC","NRAS","PTPN11","TNF"],"kegg_pathway_id":"hsa05205","pathway_name":"Proteoglycans in cancer","source":"CTD"},{"inference_gene_symbol":["ABCB1","CD44","CDKN2A","HRAS","IGF2BP1","KRAS","MET","MMP9","MYC","NRAS","PAK4"],"kegg_pathway_id":"hsa05206","pathway_name":"MicroRNAs in cancer","source":"CTD"},{"inference_gene_symbol":["KRAS","MYC"],"kegg_pathway_id":"hsa05210","pathway_name":"Colorectal cancer","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PAK4","PTPN11"],"kegg_pathway_id":"hsa05211","pathway_name":"Renal cell carcinoma","source":"CTD"},{"inference_gene_symbol":["CDKN2A","KRAS","RELA"],"kegg_pathway_id":"hsa05212","pathway_name":"Pancreatic cancer","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","MYC","NRAS"],"kegg_pathway_id":"hsa05213","pathway_name":"Endometrial cancer","source":"CTD"},{"inference_gene_symbol":["CDKN2A","HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa05214","pathway_name":"Glioma","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","RELA"],"kegg_pathway_id":"hsa05215","pathway_name":"Prostate cancer","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","MYC","NRAS","NTRK1"],"kegg_pathway_id":"hsa05216","pathway_name":"Thyroid cancer","source":"CTD"},{"inference_gene_symbol":["CDKN2A","HGF","HRAS","KRAS","MET","NRAS"],"kegg_pathway_id":"hsa05218","pathway_name":"Melanoma","source":"CTD"},{"inference_gene_symbol":["CDKN2A","HRAS","KRAS","MMP9","MYC","NRAS"],"kegg_pathway_id":"hsa05219","pathway_name":"Bladder cancer","source":"CTD"},{"inference_gene_symbol":["CDKN2A","HRAS","KRAS","MYC","NRAS","PTPN11","RELA"],"kegg_pathway_id":"hsa05220","pathway_name":"Chronic myeloid leukemia","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","MYC","NRAS","RELA"],"kegg_pathway_id":"hsa05221","pathway_name":"Acute myeloid leukemia","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","MYC","RELA"],"kegg_pathway_id":"hsa05222","pathway_name":"Small cell lung cancer","source":"CTD"},{"inference_gene_symbol":["ALK","CDKN2A","HRAS","KRAS","NRAS","RASSF5"],"kegg_pathway_id":"hsa05223","pathway_name":"Non-small cell lung cancer","source":"CTD"},{"inference_gene_symbol":["ESR1","HRAS","KRAS","MYC","NRAS"],"kegg_pathway_id":"hsa05224","pathway_name":"Breast cancer","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","MET","MYC","NRAS","NTRK1"],"kegg_pathway_id":"hsa05230","pathway_name":"Central carbon metabolism in cancer","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"kegg_pathway_id":"hsa05231","pathway_name":"Choline metabolism in cancer","source":"CTD"},{"inference_gene_symbol":"TNF","kegg_pathway_id":"hsa05310","pathway_name":"Asthma","source":"CTD"},{"inference_gene_symbol":["GATA3","IL1B","RELA","TNF"],"kegg_pathway_id":"hsa05321","pathway_name":"Inflammatory bowel disease (IBD)","source":"CTD"},{"inference_gene_symbol":"TNF","kegg_pathway_id":"hsa05322","pathway_name":"Systemic lupus erythematosus","source":"CTD"},{"inference_gene_symbol":["IL1B","TNF"],"kegg_pathway_id":"hsa05323","pathway_name":"Rheumatoid arthritis","source":"CTD"},{"inference_gene_symbol":"TNF","kegg_pathway_id":"hsa05330","pathway_name":"Allograft rejection","source":"CTD"},{"inference_gene_symbol":["IL1B","TNF"],"kegg_pathway_id":"hsa05332","pathway_name":"Graft-versus-host disease","source":"CTD"},{"inference_gene_symbol":"TNF","kegg_pathway_id":"hsa05410","pathway_name":"Hypertrophic cardiomyopathy (HCM)","source":"CTD"},{"inference_gene_symbol":["GNAS","TNF"],"kegg_pathway_id":"hsa05414","pathway_name":"Dilated cardiomyopathy","source":"CTD"},{"inference_gene_symbol":["IL1B","MMP9","RELA","TNF"],"kegg_pathway_id":"hsa05418","pathway_name":"Fluid shear stress and atherosclerosis","source":"CTD"},{"inference_gene_symbol":["DBH","TH"],"kegg_pathway_id":"hsa_M00042","pathway_name":"Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline","source":"CTD"},{"inference_gene_symbol":"COX2","kegg_pathway_id":"hsa_M00154","pathway_name":"Cytochrome c oxidase","source":"CTD"},{"inference_gene_symbol":"PSMD14","kegg_pathway_id":"hsa_M00341","pathway_name":"Proteasome, 19S regulatory particle (PA700)","source":"CTD"},{"inference_gene_symbol":"YAP1","kegg_pathway_id":"hsa_M00683","pathway_name":"Hippo signaling","source":"CTD"},{"inference_gene_symbol":"RELA","kegg_pathway_id":"hsa_M00686","pathway_name":"Toll-like receptor signaling","source":"CTD"},{"inference_gene_symbol":"CHEK2","kegg_pathway_id":"hsa_M00691","pathway_name":"DNA damage-induced cell cycle checkpoints","source":"CTD"},{"inference_gene_symbol":"GNAS","kegg_pathway_id":"hsa_M00695","pathway_name":"cAMP signaling","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Interleukin-6 signaling","react_pathway_id":"R-HSA-1059683","source":"CTD"},{"inference_gene_symbol":["BIRC2","PSMD14","TNFSF10"],"pathway_name":"Apoptosis","react_pathway_id":"R-HSA-109581","source":"CTD"},{"inference_gene_symbol":["CD44","DOCK8","GATA3","GNAS","HGF","HRAS","IFNB1","KIF1B","KRAS","MYB","NRAS","PTPN11"],"pathway_name":"Hemostasis","react_pathway_id":"R-HSA-109582","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"PI3K Cascade","react_pathway_id":"R-HSA-109704","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"MAPK3 (ERK1) activation","react_pathway_id":"R-HSA-110056","source":"CTD"},{"inference_gene_symbol":"BIRC2","pathway_name":"Apoptotic cleavage of cellular proteins","react_pathway_id":"R-HSA-111465","source":"CTD"},{"inference_gene_symbol":"BCHE","pathway_name":"Neurotransmitter Clearance In The Synaptic Cleft","react_pathway_id":"R-HSA-112311","source":"CTD"},{"inference_gene_symbol":"HRAS","pathway_name":"Neurotransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell","react_pathway_id":"R-HSA-112314","source":"CTD"},{"inference_gene_symbol":["BCHE","HRAS"],"pathway_name":"Transmission across Chemical Synapses","react_pathway_id":"R-HSA-112315","source":"CTD"},{"inference_gene_symbol":["BCHE","HRAS"],"pathway_name":"Neuronal System","react_pathway_id":"R-HSA-112316","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"IRS-mediated signalling","react_pathway_id":"R-HSA-112399","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"RAF-independent MAPK1/3 activation","react_pathway_id":"R-HSA-112409","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"MAPK1 (ERK2) activation","react_pathway_id":"R-HSA-112411","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"SOS-mediated signalling","react_pathway_id":"R-HSA-112412","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"GPVI-mediated activation cascade","react_pathway_id":"R-HSA-114604","source":"CTD"},{"inference_gene_symbol":"HGF","pathway_name":"Platelet degranulation","react_pathway_id":"R-HSA-114608","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11","RELA"],"pathway_name":"Downstream signaling events of B Cell Receptor (BCR)","react_pathway_id":"R-HSA-1168372","source":"CTD"},{"inference_gene_symbol":["PSMD14","RELA"],"pathway_name":"Activation of NF-kappaB in B cells","react_pathway_id":"R-HSA-1169091","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Activation of RAS in B cells","react_pathway_id":"R-HSA-1169092","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Prolactin receptor signaling","react_pathway_id":"R-HSA-1170546","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by FGFR in disease","react_pathway_id":"R-HSA-1226099","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by ERBB2","react_pathway_id":"R-HSA-1227986","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Regulation of Hypoxia-inducible Factor (HIF) by oxygen","react_pathway_id":"R-HSA-1234174","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","react_pathway_id":"R-HSA-1234176","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants","react_pathway_id":"R-HSA-1236382","source":"CTD"},{"inference_gene_symbol":["ESR1","HRAS","KRAS","NRAS","YAP1"],"pathway_name":"Signaling by ERBB4","react_pathway_id":"R-HSA-1236394","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"ER-Phagosome pathway","react_pathway_id":"R-HSA-1236974","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Antigen processing-Cross presentation","react_pathway_id":"R-HSA-1236975","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Cross-presentation of soluble exogenous antigens (endosomes)","react_pathway_id":"R-HSA-1236978","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"SHC1 events in ERBB2 signaling","react_pathway_id":"R-HSA-1250196","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"SHC1 events in ERBB4 signaling","react_pathway_id":"R-HSA-1250347","source":"CTD"},{"inference_gene_symbol":["ESR1","YAP1"],"pathway_name":"Nuclear signaling by ERBB4","react_pathway_id":"R-HSA-1251985","source":"CTD"},{"inference_gene_symbol":["HGF","MET","PTPN11"],"pathway_name":"PIP3 activates AKT signaling","react_pathway_id":"R-HSA-1257604","source":"CTD"},{"inference_gene_symbol":"HGF","pathway_name":"Interleukin-7 signaling","react_pathway_id":"R-HSA-1266695","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","MMP9","NRAS","PAK4","PSMD14","PTPN11","RELA","TNF"],"pathway_name":"Developmental Biology","react_pathway_id":"R-HSA-1266738","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","CD44","GATA3","HGF","HRAS","IFNB1","IL1B","KRAS","MET","MMP9","MYC","NRAS","PSMD14","PTPN11","RELA","TNF"],"pathway_name":"Cytokine Signaling in Immune system","react_pathway_id":"R-HSA-1280215","source":"CTD"},{"inference_gene_symbol":["HACE1","HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11","RELA"],"pathway_name":"Adaptive Immune System","react_pathway_id":"R-HSA-1280218","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Spry regulation of FGF signaling","react_pathway_id":"R-HSA-1295596","source":"CTD"},{"inference_gene_symbol":"TNFSF10","pathway_name":"Ligand-dependent caspase activation","react_pathway_id":"R-HSA-140534","source":"CTD"},{"inference_gene_symbol":"COX2","pathway_name":"The citric acid (TCA) cycle and respiratory electron transport","react_pathway_id":"R-HSA-1428517","source":"CTD"},{"inference_gene_symbol":["ABCB1","BCHE","CD44","COX2","DBH","GNAS","NT5E","PSMD14","TH","YAP1"],"pathway_name":"Metabolism","react_pathway_id":"R-HSA-1430728","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","MMP9","NRAS","PSMD14","PTPN11"],"pathway_name":"Signaling by SCF-KIT","react_pathway_id":"R-HSA-1433557","source":"CTD"},{"inference_gene_symbol":"MMP9","pathway_name":"Collagen degradation","react_pathway_id":"R-HSA-1442490","source":"CTD"},{"inference_gene_symbol":["CD44","MMP9"],"pathway_name":"Degradation of the extracellular matrix","react_pathway_id":"R-HSA-1474228","source":"CTD"},{"inference_gene_symbol":["CD44","MMP9"],"pathway_name":"Extracellular matrix organization","react_pathway_id":"R-HSA-1474244","source":"CTD"},{"inference_gene_symbol":"MMP9","pathway_name":"Collagen formation","react_pathway_id":"R-HSA-1474290","source":"CTD"},{"inference_gene_symbol":"BCHE","pathway_name":"Synthesis of PC","react_pathway_id":"R-HSA-1483191","source":"CTD"},{"inference_gene_symbol":"BCHE","pathway_name":"Glycerophospholipid biosynthesis","react_pathway_id":"R-HSA-1483206","source":"CTD"},{"inference_gene_symbol":"BCHE","pathway_name":"Phospholipid metabolism","react_pathway_id":"R-HSA-1483257","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Cell-Cell communication","react_pathway_id":"R-HSA-1500931","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"Signaling by NOTCH","react_pathway_id":"R-HSA-157118","source":"CTD"},{"inference_gene_symbol":"TERT","pathway_name":"Telomere Maintenance","react_pathway_id":"R-HSA-157579","source":"CTD"},{"inference_gene_symbol":"NT5E","pathway_name":"Metabolism of nucleotides","react_pathway_id":"R-HSA-15869","source":"CTD"},{"inference_gene_symbol":"MMP9","pathway_name":"Activation of Matrix Metalloproteinases","react_pathway_id":"R-HSA-1592389","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"ZBP1(DAI) mediated induction of type I IFNs","react_pathway_id":"R-HSA-1606322","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","ESR1","GNAS","HGF","HRAS","IGF2BP1","KRAS","MET","MMP9","MYC","NRAS","NTRK1","NTRK2","PSMD14","PTPN11","RELA","TERT","TNF","TNFSF10","YAP1"],"pathway_name":"Signal Transduction","react_pathway_id":"R-HSA-162582","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"HIV Infection","react_pathway_id":"R-HSA-162906","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Host Interactions of HIV factors","react_pathway_id":"R-HSA-162909","source":"CTD"},{"inference_gene_symbol":"CD44","pathway_name":"Glycosaminoglycan metabolism","react_pathway_id":"R-HSA-1630316","source":"CTD"},{"inference_gene_symbol":"COX2","pathway_name":"Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.","react_pathway_id":"R-HSA-163200","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"Glucagon signaling in metabolic regulation","react_pathway_id":"R-HSA-163359","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"Integration of energy metabolism","react_pathway_id":"R-HSA-163685","source":"CTD"},{"inference_gene_symbol":["AURKA","BARD1","CDKN2A","CHEK2","MYC","PSMD14","TERT"],"pathway_name":"Cell Cycle","react_pathway_id":"R-HSA-1640170","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","MYC","NRAS","PSMD14","PTPN11","RELA"],"pathway_name":"Disease","react_pathway_id":"R-HSA-1643685","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by EGFR in Cancer","react_pathway_id":"R-HSA-1643713","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"PKA activation in glucagon signalling","react_pathway_id":"R-HSA-164378","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","PTPN11","RELA"],"pathway_name":"Toll Like Receptor 4 (TLR4) Cascade","react_pathway_id":"R-HSA-166016","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","PTPN11","RELA"],"pathway_name":"Activated TLR4 signalling","react_pathway_id":"R-HSA-166054","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"MyD88:Mal cascade initiated on plasma membrane","react_pathway_id":"R-HSA-166058","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","PTPN11","RELA"],"pathway_name":"MyD88-independent TLR3/TLR4 cascade","react_pathway_id":"R-HSA-166166","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","NTRK1","NTRK2","PSMD14","PTPN11","RELA"],"pathway_name":"Signalling by NGF","react_pathway_id":"R-HSA-166520","source":"CTD"},{"inference_gene_symbol":"NTRK1","pathway_name":"PLC-gamma1 signalling","react_pathway_id":"R-HSA-167021","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","NTRK1","PSMD14"],"pathway_name":"Signalling to RAS","react_pathway_id":"R-HSA-167044","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"Toll Like Receptor 9 (TLR9) Cascade","react_pathway_id":"R-HSA-168138","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"Toll Like Receptor 10 (TLR10) Cascade","react_pathway_id":"R-HSA-168142","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","PTPN11","RELA"],"pathway_name":"Toll Like Receptor 3 (TLR3) Cascade","react_pathway_id":"R-HSA-168164","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"Toll Like Receptor 5 (TLR5) Cascade","react_pathway_id":"R-HSA-168176","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"Toll Like Receptor TLR1:TLR2 Cascade","react_pathway_id":"R-HSA-168179","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"Toll Like Receptor 7/8 (TLR7/8) Cascade","react_pathway_id":"R-HSA-168181","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"Toll Like Receptor TLR6:TLR2 Cascade","react_pathway_id":"R-HSA-168188","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","CD44","HGF","HRAS","IFNB1","IL1B","KRAS","MET","MMP9","NRAS","PSMD14","PTPN11","RELA"],"pathway_name":"Innate Immune System","react_pathway_id":"R-HSA-168249","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","CD44","GATA3","HACE1","HGF","HRAS","IFNB1","IL1B","KRAS","MET","MMP9","MYC","NRAS","PSMD14","PTPN11","RELA","TNF"],"pathway_name":"Immune System","react_pathway_id":"R-HSA-168256","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3"],"pathway_name":"NOD1/2 Signaling Pathway","react_pathway_id":"R-HSA-168638","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3"],"pathway_name":"Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways","react_pathway_id":"R-HSA-168643","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","PTPN11","RELA"],"pathway_name":"Toll-Like Receptors Cascades","react_pathway_id":"R-HSA-168898","source":"CTD"},{"inference_gene_symbol":["IFNB1","RELA"],"pathway_name":"RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways","react_pathway_id":"R-HSA-168928","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","NTRK1","PSMD14"],"pathway_name":"Prolonged ERK activation events","react_pathway_id":"R-HSA-169893","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Regulation of Apoptosis","react_pathway_id":"R-HSA-169911","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"Signaling by TGF-beta Receptor Complex","react_pathway_id":"R-HSA-170834","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","NTRK1","PSMD14"],"pathway_name":"Frs2-mediated activation","react_pathway_id":"R-HSA-170968","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","NTRK1","PSMD14"],"pathway_name":"ARMS-mediated activation","react_pathway_id":"R-HSA-170984","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"p38MAPK events","react_pathway_id":"R-HSA-171007","source":"CTD"},{"inference_gene_symbol":"TERT","pathway_name":"Telomere Extension By Telomerase","react_pathway_id":"R-HSA-171319","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Autodegradation of Cdh1 by Cdh1:APC/C","react_pathway_id":"R-HSA-174084","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"SCF-beta-TrCP mediated degradation of Emi1","react_pathway_id":"R-HSA-174113","source":"CTD"},{"inference_gene_symbol":["AURKA","PSMD14"],"pathway_name":"APC/C-mediated degradation of cell cycle proteins","react_pathway_id":"R-HSA-174143","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"APC/C:Cdc20 mediated degradation of Securin","react_pathway_id":"R-HSA-174154","source":"CTD"},{"inference_gene_symbol":["AURKA","PSMD14"],"pathway_name":"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1","react_pathway_id":"R-HSA-174178","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Cdc20:Phospho-APC/C mediated degradation of Cyclin A","react_pathway_id":"R-HSA-174184","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Regulation of APC/C activators between G1/S and early anaphase","react_pathway_id":"R-HSA-176408","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"APC/C:Cdc20 mediated degradation of mitotic proteins","react_pathway_id":"R-HSA-176409","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","react_pathway_id":"R-HSA-176814","source":"CTD"},{"inference_gene_symbol":"NTRK1","pathway_name":"Retrograde neurotrophin signalling","react_pathway_id":"R-HSA-177504","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"Signaling by EGFR","react_pathway_id":"R-HSA-177929","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","react_pathway_id":"R-HSA-179419","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"GRB2 events in EGFR signaling","react_pathway_id":"R-HSA-179812","source":"CTD"},{"inference_gene_symbol":["HGF","MET","PTPN11"],"pathway_name":"GAB1 signalosome","react_pathway_id":"R-HSA-180292","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"SHC1 events in EGFR signaling","react_pathway_id":"R-HSA-180336","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Vpu mediated degradation of CD4","react_pathway_id":"R-HSA-180534","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Vif-mediated degradation of APOBEC3G","react_pathway_id":"R-HSA-180585","source":"CTD"},{"inference_gene_symbol":"TERT","pathway_name":"Extension of Telomeres","react_pathway_id":"R-HSA-180786","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"RIP-mediated NFkB activation via ZBP1","react_pathway_id":"R-HSA-1810476","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"Toll Like Receptor 2 (TLR2) Cascade","react_pathway_id":"R-HSA-181438","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"Cytosolic sensors of pathogen-associated DNA","react_pathway_id":"R-HSA-1834949","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"Downstream signal transduction","react_pathway_id":"R-HSA-186763","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"Signaling by PDGF","react_pathway_id":"R-HSA-186797","source":"CTD"},{"inference_gene_symbol":["NTRK1","NTRK2"],"pathway_name":"Activation of TRKA receptors","react_pathway_id":"R-HSA-187015","source":"CTD"},{"inference_gene_symbol":["NTRK1","NTRK2"],"pathway_name":"NGF-independant TRKA activation","react_pathway_id":"R-HSA-187024","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","NTRK1","NTRK2","PSMD14","PTPN11"],"pathway_name":"NGF signalling via TRKA from the plasma membrane","react_pathway_id":"R-HSA-187037","source":"CTD"},{"inference_gene_symbol":"NTRK1","pathway_name":"TRKA activation by NGF","react_pathway_id":"R-HSA-187042","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"SCF(Skp2)-mediated degradation of p27/p21","react_pathway_id":"R-HSA-187577","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","NTRK1","PSMD14"],"pathway_name":"Signalling to ERKs","react_pathway_id":"R-HSA-187687","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","NTRK1","PSMD14"],"pathway_name":"Signalling to p38 via RIT and RIN","react_pathway_id":"R-HSA-187706","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"Signaling by FGFR","react_pathway_id":"R-HSA-190236","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"p75NTR signals via NF-kB","react_pathway_id":"R-HSA-193639","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"Regulated proteolysis of p75NTR","react_pathway_id":"R-HSA-193692","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"p75 NTR receptor-mediated signalling","react_pathway_id":"R-HSA-193704","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"Signaling by VEGF","react_pathway_id":"R-HSA-194138","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Degradation of beta-catenin by the destruction complex","react_pathway_id":"R-HSA-195253","source":"CTD"},{"inference_gene_symbol":["MYC","PSMD14","TERT"],"pathway_name":"Signaling by Wnt","react_pathway_id":"R-HSA-195721","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"GRB2 events in ERBB2 signaling","react_pathway_id":"R-HSA-1963640","source":"CTD"},{"inference_gene_symbol":"NT5E","pathway_name":"Nicotinate metabolism","react_pathway_id":"R-HSA-196807","source":"CTD"},{"inference_gene_symbol":"NT5E","pathway_name":"Metabolism of water-soluble vitamins and cofactors","react_pathway_id":"R-HSA-196849","source":"CTD"},{"inference_gene_symbol":"NT5E","pathway_name":"Metabolism of vitamins and cofactors","react_pathway_id":"R-HSA-196854","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"Signaling by NOTCH1","react_pathway_id":"R-HSA-1980143","source":"CTD"},{"inference_gene_symbol":["HGF","MET","NTRK1","PTPN11"],"pathway_name":"PI3K/AKT activation","react_pathway_id":"R-HSA-198203","source":"CTD"},{"inference_gene_symbol":"NTRK1","pathway_name":"Signalling to STAT3","react_pathway_id":"R-HSA-198745","source":"CTD"},{"inference_gene_symbol":"YAP1","pathway_name":"PPARA activates gene expression","react_pathway_id":"R-HSA-1989781","source":"CTD"},{"inference_gene_symbol":["HGF","MET","PTPN11"],"pathway_name":"Negative regulation of the PI3K/AKT network","react_pathway_id":"R-HSA-199418","source":"CTD"},{"inference_gene_symbol":"KIF1B","pathway_name":"Membrane Trafficking","react_pathway_id":"R-HSA-199991","source":"CTD"},{"inference_gene_symbol":["MYC","PSMD14","TERT"],"pathway_name":"TCF dependent signaling in response to WNT","react_pathway_id":"R-HSA-201681","source":"CTD"},{"inference_gene_symbol":["MYC","TERT"],"pathway_name":"Formation of the beta-catenin:TCF transactivating complex","react_pathway_id":"R-HSA-201722","source":"CTD"},{"inference_gene_symbol":"MMP9","pathway_name":"Assembly of collagen fibrils and other multimeric structures","react_pathway_id":"R-HSA-2022090","source":"CTD"},{"inference_gene_symbol":["PSMD14","RELA"],"pathway_name":"TCR signaling","react_pathway_id":"R-HSA-202403","source":"CTD"},{"inference_gene_symbol":["PSMD14","RELA"],"pathway_name":"Downstream TCR signaling","react_pathway_id":"R-HSA-202424","source":"CTD"},{"inference_gene_symbol":["CD44","HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"Cell surface interactions at the vascular wall","react_pathway_id":"R-HSA-202733","source":"CTD"},{"inference_gene_symbol":"YAP1","pathway_name":"Signaling by Hippo","react_pathway_id":"R-HSA-2028269","source":"CTD"},{"inference_gene_symbol":"YAP1","pathway_name":"YAP1- and WWTR1 (TAZ)-stimulated gene expression","react_pathway_id":"R-HSA-2032785","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"NF-kB is activated and signals survival","react_pathway_id":"R-HSA-209560","source":"CTD"},{"inference_gene_symbol":["DBH","TH"],"pathway_name":"Amine-derived hormones","react_pathway_id":"R-HSA-209776","source":"CTD"},{"inference_gene_symbol":["DBH","TH"],"pathway_name":"Catecholamine biosynthesis","react_pathway_id":"R-HSA-209905","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"PECAM1 interactions","react_pathway_id":"R-HSA-210990","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"Tie2 Signaling","react_pathway_id":"R-HSA-210993","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Regulation of activated PAK-2p34 by proteasome mediated degradation","react_pathway_id":"R-HSA-211733","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"NOTCH1 Intracellular Domain Regulates Transcription","react_pathway_id":"R-HSA-2122947","source":"CTD"},{"inference_gene_symbol":["AURKA","BARD1","CDKN2A","CHEK2","COX2","ESR1","MYC","YAP1"],"pathway_name":"Generic Transcription Pathway","react_pathway_id":"R-HSA-212436","source":"CTD"},{"inference_gene_symbol":"CD44","pathway_name":"Hyaluronan metabolism","react_pathway_id":"R-HSA-2142845","source":"CTD"},{"inference_gene_symbol":"CD44","pathway_name":"Integrin cell surface interactions","react_pathway_id":"R-HSA-216083","source":"CTD"},{"inference_gene_symbol":"CD44","pathway_name":"Hyaluronan uptake and degradation","react_pathway_id":"R-HSA-2160916","source":"CTD"},{"inference_gene_symbol":"ABCB1","pathway_name":"Abacavir transmembrane transport","react_pathway_id":"R-HSA-2161517","source":"CTD"},{"inference_gene_symbol":"ABCB1","pathway_name":"Abacavir transport and metabolism","react_pathway_id":"R-HSA-2161522","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"DAP12 interactions","react_pathway_id":"R-HSA-2172127","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer","react_pathway_id":"R-HSA-2173793","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription","react_pathway_id":"R-HSA-2173796","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"EGFR Transactivation by Gastrin","react_pathway_id":"R-HSA-2179392","source":"CTD"},{"inference_gene_symbol":["HGF","MET","PTPN11"],"pathway_name":"PI3K/AKT Signaling in Cancer","react_pathway_id":"R-HSA-2219528","source":"CTD"},{"inference_gene_symbol":["HGF","MET","PTPN11"],"pathway_name":"Constitutive Signaling by Aberrant PI3K in Cancer","react_pathway_id":"R-HSA-2219530","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Cellular response to hypoxia","react_pathway_id":"R-HSA-2262749","source":"CTD"},{"inference_gene_symbol":["CDKN2A","IFNB1","PSMD14","RELA"],"pathway_name":"Cellular responses to stress","react_pathway_id":"R-HSA-2262752","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","react_pathway_id":"R-HSA-2404192","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"DAP12 signaling","react_pathway_id":"R-HSA-2424491","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"IGF1R signaling cascade","react_pathway_id":"R-HSA-2428924","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"IRS-related events triggered by IGF1R","react_pathway_id":"R-HSA-2428928","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"SHC-related events triggered by IGF1R","react_pathway_id":"R-HSA-2428933","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11","RELA"],"pathway_name":"Fc epsilon receptor (FCERI) signaling","react_pathway_id":"R-HSA-2454202","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Separation of Sister Chromatids","react_pathway_id":"R-HSA-2467813","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Mitotic Metaphase and Anaphase","react_pathway_id":"R-HSA-2555396","source":"CTD"},{"inference_gene_symbol":["CDKN2A","IFNB1"],"pathway_name":"Oxidative Stress Induced Senescence","react_pathway_id":"R-HSA-2559580","source":"CTD"},{"inference_gene_symbol":["CDKN2A","RELA"],"pathway_name":"Senescence-Associated Secretory Phenotype (SASP)","react_pathway_id":"R-HSA-2559582","source":"CTD"},{"inference_gene_symbol":["CDKN2A","IFNB1","RELA"],"pathway_name":"Cellular Senescence","react_pathway_id":"R-HSA-2559583","source":"CTD"},{"inference_gene_symbol":"CDKN2A","pathway_name":"Oncogene Induced Senescence","react_pathway_id":"R-HSA-2559585","source":"CTD"},{"inference_gene_symbol":"AURKA","pathway_name":"Regulation of PLK1 Activity at G2/M Transition","react_pathway_id":"R-HSA-2565942","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"Signaling by Leptin","react_pathway_id":"R-HSA-2586552","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"Signaling by NOTCH1 PEST Domain Mutants in Cancer","react_pathway_id":"R-HSA-2644602","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"Signaling by NOTCH1 in Cancer","react_pathway_id":"R-HSA-2644603","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"Constitutive Signaling by NOTCH1 PEST Domain Mutants","react_pathway_id":"R-HSA-2644606","source":"CTD"},{"inference_gene_symbol":["HRAS","MMP9"],"pathway_name":"EPH-Ephrin signaling","react_pathway_id":"R-HSA-2682334","source":"CTD"},{"inference_gene_symbol":["HGF","MET","PTPN11"],"pathway_name":"Role of LAT2/NTAL/LAB on calcium mobilization","react_pathway_id":"R-HSA-2730905","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"FCERI mediated MAPK activation","react_pathway_id":"R-HSA-2871796","source":"CTD"},{"inference_gene_symbol":["PSMD14","RELA"],"pathway_name":"FCERI mediated NF-kB activation","react_pathway_id":"R-HSA-2871837","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","react_pathway_id":"R-HSA-2894858","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","react_pathway_id":"R-HSA-2894862","source":"CTD"},{"inference_gene_symbol":["BCHE","ISL1"],"pathway_name":"Peptide hormone metabolism","react_pathway_id":"R-HSA-2980736","source":"CTD"},{"inference_gene_symbol":["AURKA","CDKN2A"],"pathway_name":"SUMOylation","react_pathway_id":"R-HSA-2990846","source":"CTD"},{"inference_gene_symbol":"CDKN2A","pathway_name":"SUMOylation of DNA damage response and repair proteins","react_pathway_id":"R-HSA-3108214","source":"CTD"},{"inference_gene_symbol":["AURKA","CDKN2A"],"pathway_name":"SUMO E3 ligases SUMOylate target proteins","react_pathway_id":"R-HSA-3108232","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"DEx/H-box helicases activate type I IFN and inflammatory cytokines production","react_pathway_id":"R-HSA-3134963","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"PKMTs methylate histone lysines","react_pathway_id":"R-HSA-3214841","source":"CTD"},{"inference_gene_symbol":["ARID1A","ARID1B"],"pathway_name":"RMTs methylate histone arginines","react_pathway_id":"R-HSA-3214858","source":"CTD"},{"inference_gene_symbol":"CDKN2A","pathway_name":"SUMOylation of transcription factors","react_pathway_id":"R-HSA-3232118","source":"CTD"},{"inference_gene_symbol":["ARID1A","ARID1B","RELA"],"pathway_name":"Chromatin modifying enzymes","react_pathway_id":"R-HSA-3247509","source":"CTD"},{"inference_gene_symbol":"TNFSF10","pathway_name":"Regulation by c-FLIP","react_pathway_id":"R-HSA-3371378","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Autodegradation of the E3 ubiquitin ligase COP1","react_pathway_id":"R-HSA-349425","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Regulation of ornithine decarboxylase (ODC)","react_pathway_id":"R-HSA-350562","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Metabolism of polyamines","react_pathway_id":"R-HSA-351202","source":"CTD"},{"inference_gene_symbol":["AURKA","BARD1","CDKN2A","CHEK2","COX2"],"pathway_name":"Transcriptional Regulation by TP53","react_pathway_id":"R-HSA-3700989","source":"CTD"},{"inference_gene_symbol":["GNAS","HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"Signaling by GPCR","react_pathway_id":"R-HSA-372790","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"Class B/2 (Secretin family receptors)","react_pathway_id":"R-HSA-373080","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Netrin-1 signaling","react_pathway_id":"R-HSA-373752","source":"CTD"},{"inference_gene_symbol":"MET","pathway_name":"Semaphorin interactions","react_pathway_id":"R-HSA-373755","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"NCAM signaling for neurite out-growth","react_pathway_id":"R-HSA-375165","source":"CTD"},{"inference_gene_symbol":"PAK4","pathway_name":"Signaling by Robo receptor","react_pathway_id":"R-HSA-376176","source":"CTD"},{"inference_gene_symbol":["RELA","TNF"],"pathway_name":"Transcriptional regulation of white adipocyte differentiation","react_pathway_id":"R-HSA-381340","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion","react_pathway_id":"R-HSA-381676","source":"CTD"},{"inference_gene_symbol":["ABCB1","GNAS","PSMD14"],"pathway_name":"Transmembrane transport of small molecules","react_pathway_id":"R-HSA-382551","source":"CTD"},{"inference_gene_symbol":["ABCB1","PSMD14"],"pathway_name":"ABC-family proteins mediated transport","react_pathway_id":"R-HSA-382556","source":"CTD"},{"inference_gene_symbol":"ESR1","pathway_name":"Nuclear Receptor transcription pathway","react_pathway_id":"R-HSA-383280","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Beta-catenin independent WNT signaling","react_pathway_id":"R-HSA-3858494","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"GPCR downstream signaling","react_pathway_id":"R-HSA-388396","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Costimulation by the CD28 family","react_pathway_id":"R-HSA-388841","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"CTLA4 inhibitory signaling","react_pathway_id":"R-HSA-389513","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"PD-1 signaling","react_pathway_id":"R-HSA-389948","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Signal regulatory protein (SIRP) family interactions","react_pathway_id":"R-HSA-391160","source":"CTD"},{"inference_gene_symbol":["AURKA","BARD1","BCHE","BIRC2","BIRC3","CDKN2A","ESR1","GATA3","ISL1","MYC","PSMD14"],"pathway_name":"Metabolism of proteins","react_pathway_id":"R-HSA-392499","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"Prostacyclin signalling through prostacyclin receptor","react_pathway_id":"R-HSA-392851","source":"CTD"},{"inference_gene_symbol":"HRAS","pathway_name":"EPHB-mediated forward signaling","react_pathway_id":"R-HSA-3928662","source":"CTD"},{"inference_gene_symbol":"MMP9","pathway_name":"EPH-ephrin mediated repulsion of cells","react_pathway_id":"R-HSA-3928665","source":"CTD"},{"inference_gene_symbol":"YAP1","pathway_name":"Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)","react_pathway_id":"R-HSA-400206","source":"CTD"},{"inference_gene_symbol":"ISL1","pathway_name":"Incretin synthesis, secretion, and inactivation","react_pathway_id":"R-HSA-400508","source":"CTD"},{"inference_gene_symbol":"ISL1","pathway_name":"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)","react_pathway_id":"R-HSA-400511","source":"CTD"},{"inference_gene_symbol":"MET","pathway_name":"Sema4D in semaphorin signaling","react_pathway_id":"R-HSA-400685","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"PCP/CE pathway","react_pathway_id":"R-HSA-4086400","source":"CTD"},{"inference_gene_symbol":"MET","pathway_name":"Sema4D mediated inhibition of cell attachment and migration","react_pathway_id":"R-HSA-416550","source":"CTD"},{"inference_gene_symbol":["GNAS","PTPN11"],"pathway_name":"Platelet homeostasis","react_pathway_id":"R-HSA-418346","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"G alpha (s) signalling events","react_pathway_id":"R-HSA-418555","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"G alpha (i) signalling events","react_pathway_id":"R-HSA-418594","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"G alpha (z) signalling events","react_pathway_id":"R-HSA-418597","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Netrin mediated repulsion signals","react_pathway_id":"R-HSA-418886","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"Glucagon-type ligand receptors","react_pathway_id":"R-HSA-420092","source":"CTD"},{"inference_gene_symbol":"BCHE","pathway_name":"Synthesis, secretion, and deacylation of Ghrelin","react_pathway_id":"R-HSA-422085","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"Regulation of insulin secretion","react_pathway_id":"R-HSA-422356","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","MMP9","NRAS","PAK4","PSMD14","PTPN11"],"pathway_name":"Axon guidance","react_pathway_id":"R-HSA-422475","source":"CTD"},{"inference_gene_symbol":"IGF2BP1","pathway_name":"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","react_pathway_id":"R-HSA-428359","source":"CTD"},{"inference_gene_symbol":"PAK4","pathway_name":"Activation of Rac","react_pathway_id":"R-HSA-428540","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"Vasopressin regulates renal water homeostasis via Aquaporins","react_pathway_id":"R-HSA-432040","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Platelet sensitization by LDL","react_pathway_id":"R-HSA-432142","source":"CTD"},{"inference_gene_symbol":"HRAS","pathway_name":"Post NMDA receptor activation events","react_pathway_id":"R-HSA-438064","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"Binding of TCF/LEF:CTNNB1 to target gene promoters","react_pathway_id":"R-HSA-4411364","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"VEGFA-VEGFR2 Pathway","react_pathway_id":"R-HSA-4420097","source":"CTD"},{"inference_gene_symbol":"HRAS","pathway_name":"CREB phosphorylation through the activation of Ras","react_pathway_id":"R-HSA-442742","source":"CTD"},{"inference_gene_symbol":"HRAS","pathway_name":"Activation of NMDA receptor upon glutamate binding and postsynaptic events","react_pathway_id":"R-HSA-442755","source":"CTD"},{"inference_gene_symbol":"HRAS","pathway_name":"Ras activation uopn Ca2+ infux through NMDA receptor","react_pathway_id":"R-HSA-442982","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"Aquaporin-mediated transport","react_pathway_id":"R-HSA-445717","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"TAK1 activates NFkB by phosphorylation and activation of IKKs complex","react_pathway_id":"R-HSA-445989","source":"CTD"},{"inference_gene_symbol":"IL1B","pathway_name":"Interleukin-1 signaling","react_pathway_id":"R-HSA-446652","source":"CTD"},{"inference_gene_symbol":["IL1B","RELA"],"pathway_name":"Interleukin-1 processing","react_pathway_id":"R-HSA-448706","source":"CTD"},{"inference_gene_symbol":["GATA3","HGF","HRAS","IL1B","KRAS","MET","MMP9","MYC","NRAS","PSMD14","PTPN11","RELA","TNF"],"pathway_name":"Signaling by Interleukins","react_pathway_id":"R-HSA-449147","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"AUF1 (hnRNP D0) binds and destabilizes mRNA","react_pathway_id":"R-HSA-450408","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Regulation of mRNA stability by proteins that bind AU-rich elements","react_pathway_id":"R-HSA-450531","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"Interleukin-2 signaling","react_pathway_id":"R-HSA-451927","source":"CTD"},{"inference_gene_symbol":["AURKA","PSMD14"],"pathway_name":"Mitotic G2-G2/M phases","react_pathway_id":"R-HSA-453274","source":"CTD"},{"inference_gene_symbol":["AURKA","PSMD14"],"pathway_name":"Regulation of mitotic cell cycle","react_pathway_id":"R-HSA-453276","source":"CTD"},{"inference_gene_symbol":["CDKN2A","MYC","PSMD14"],"pathway_name":"Mitotic G1-G1/S phases","react_pathway_id":"R-HSA-453279","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Asymmetric localization of PCP proteins","react_pathway_id":"R-HSA-4608870","source":"CTD"},{"inference_gene_symbol":"AURKA","pathway_name":"SUMOylation of DNA replication proteins","react_pathway_id":"R-HSA-4615885","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Degradation of AXIN","react_pathway_id":"R-HSA-4641257","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Degradation of DVL","react_pathway_id":"R-HSA-4641258","source":"CTD"},{"inference_gene_symbol":["ARID1A","ARID1B","RELA"],"pathway_name":"Chromatin organization","react_pathway_id":"R-HSA-4839726","source":"CTD"},{"inference_gene_symbol":"GNAS","pathway_name":"GPCR ligand binding","react_pathway_id":"R-HSA-500792","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"Interleukin-3, 5 and GM-CSF signaling","react_pathway_id":"R-HSA-512988","source":"CTD"},{"inference_gene_symbol":"PINK1","pathway_name":"Mitophagy","react_pathway_id":"R-HSA-5205647","source":"CTD"},{"inference_gene_symbol":"PINK1","pathway_name":"Pink/Parkin Mediated Mitophagy","react_pathway_id":"R-HSA-5205685","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","TNFSF10"],"pathway_name":"RIPK1-mediated regulated necrosis","react_pathway_id":"R-HSA-5213460","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","TNFSF10"],"pathway_name":"Regulated Necrosis","react_pathway_id":"R-HSA-5218859","source":"CTD"},{"inference_gene_symbol":"TNFSF10","pathway_name":"CASP8 activity is inhibited","react_pathway_id":"R-HSA-5218900","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"VEGFR2 mediated cell proliferation","react_pathway_id":"R-HSA-5218921","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"Diseases of Immune System","react_pathway_id":"R-HSA-5260271","source":"CTD"},{"inference_gene_symbol":"YAP1","pathway_name":"Fatty acid, triacylglycerol, and ketone body metabolism","react_pathway_id":"R-HSA-535734","source":"CTD"},{"inference_gene_symbol":"TNFSF10","pathway_name":"Caspase activation via extrinsic apoptotic signalling pathway","react_pathway_id":"R-HSA-5357769","source":"CTD"},{"inference_gene_symbol":"TNF","pathway_name":"TNFR1-induced proapoptotic signaling","react_pathway_id":"R-HSA-5357786","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","PSMD14","TNFSF10"],"pathway_name":"Programmed Cell Death","react_pathway_id":"R-HSA-5357801","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","TNF"],"pathway_name":"Regulation of TNFR1 signaling","react_pathway_id":"R-HSA-5357905","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","TNF"],"pathway_name":"TNFR1-induced NFkappaB signaling pathway","react_pathway_id":"R-HSA-5357956","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Hedgehog ligand biogenesis","react_pathway_id":"R-HSA-5358346","source":"CTD"},{"inference_gene_symbol":["GNAS","PSMD14"],"pathway_name":"Signaling by Hedgehog","react_pathway_id":"R-HSA-5358351","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD","react_pathway_id":"R-HSA-5362768","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Hh mutants abrogate ligand secretion","react_pathway_id":"R-HSA-5387390","source":"CTD"},{"inference_gene_symbol":["BCHE","YAP1"],"pathway_name":"Metabolism of lipids and lipoproteins","react_pathway_id":"R-HSA-556833","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"Diseases associated with the TLR signaling cascade","react_pathway_id":"R-HSA-5602358","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)","react_pathway_id":"R-HSA-5603027","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"IkBA variant leads to EDA-ID","react_pathway_id":"R-HSA-5603029","source":"CTD"},{"inference_gene_symbol":["PSMD14","RELA"],"pathway_name":"Dectin-1 mediated noncanonical NF-kB signaling","react_pathway_id":"R-HSA-5607761","source":"CTD"},{"inference_gene_symbol":["IL1B","PSMD14","RELA"],"pathway_name":"CLEC7A (Dectin-1) signaling","react_pathway_id":"R-HSA-5607764","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Degradation of GLI1 by the proteasome","react_pathway_id":"R-HSA-5610780","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Degradation of GLI2 by the proteasome","react_pathway_id":"R-HSA-5610783","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"GLI3 is processed to GLI3R by the proteasome","react_pathway_id":"R-HSA-5610785","source":"CTD"},{"inference_gene_symbol":["GNAS","PSMD14"],"pathway_name":"Hedgehog 'off' state","react_pathway_id":"R-HSA-5610787","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"ABC transporter disorders","react_pathway_id":"R-HSA-5619084","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Disorders of transmembrane transporters","react_pathway_id":"R-HSA-5619115","source":"CTD"},{"inference_gene_symbol":["HRAS","IL1B","KRAS","NRAS","PSMD14","RELA"],"pathway_name":"C-type lectin receptors (CLRs)","react_pathway_id":"R-HSA-5621481","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","RELA"],"pathway_name":"CD209 (DC-SIGN) signaling","react_pathway_id":"R-HSA-5621575","source":"CTD"},{"inference_gene_symbol":"TNF","pathway_name":"TNFR1-mediated ceramide production","react_pathway_id":"R-HSA-5626978","source":"CTD"},{"inference_gene_symbol":"COX2","pathway_name":"TP53 Regulates Metabolic Genes","react_pathway_id":"R-HSA-5628897","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Hedgehog 'on' state","react_pathway_id":"R-HSA-5632684","source":"CTD"},{"inference_gene_symbol":["AURKA","BARD1","CDKN2A","CHEK2"],"pathway_name":"Regulation of TP53 Activity","react_pathway_id":"R-HSA-5633007","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Constitutive Signaling by EGFRvIII","react_pathway_id":"R-HSA-5637810","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by EGFRvIII in Cancer","react_pathway_id":"R-HSA-5637812","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by Ligand-Responsive EGFR Variants in Cancer","react_pathway_id":"R-HSA-5637815","source":"CTD"},{"inference_gene_symbol":"KIF1B","pathway_name":"Vesicle-mediated transport","react_pathway_id":"R-HSA-5653656","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"Downstream signaling of activated FGFR1","react_pathway_id":"R-HSA-5654687","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"SHC-mediated cascade:FGFR1","react_pathway_id":"R-HSA-5654688","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"PI-3K cascade:FGFR1","react_pathway_id":"R-HSA-5654689","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"FRS-mediated FGFR1 signaling","react_pathway_id":"R-HSA-5654693","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"PI-3K cascade:FGFR2","react_pathway_id":"R-HSA-5654695","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"Downstream signaling of activated FGFR2","react_pathway_id":"R-HSA-5654696","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"SHC-mediated cascade:FGFR2","react_pathway_id":"R-HSA-5654699","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"FRS-mediated FGFR2 signaling","react_pathway_id":"R-HSA-5654700","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"SHC-mediated cascade:FGFR3","react_pathway_id":"R-HSA-5654704","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"FRS-mediated FGFR3 signaling","react_pathway_id":"R-HSA-5654706","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"Downstream signaling of activated FGFR3","react_pathway_id":"R-HSA-5654708","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"PI-3K cascade:FGFR3","react_pathway_id":"R-HSA-5654710","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"FRS-mediated FGFR4 signaling","react_pathway_id":"R-HSA-5654712","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"Downstream signaling of activated FGFR4","react_pathway_id":"R-HSA-5654716","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"SHC-mediated cascade:FGFR4","react_pathway_id":"R-HSA-5654719","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"PI-3K cascade:FGFR4","react_pathway_id":"R-HSA-5654720","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Negative regulation of FGFR1 signaling","react_pathway_id":"R-HSA-5654726","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Negative regulation of FGFR2 signaling","react_pathway_id":"R-HSA-5654727","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Negative regulation of FGFR3 signaling","react_pathway_id":"R-HSA-5654732","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Negative regulation of FGFR4 signaling","react_pathway_id":"R-HSA-5654733","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"Signaling by FGFR1","react_pathway_id":"R-HSA-5654736","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"Signaling by FGFR2","react_pathway_id":"R-HSA-5654738","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"Signaling by FGFR3","react_pathway_id":"R-HSA-5654741","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PTPN11"],"pathway_name":"Signaling by FGFR4","react_pathway_id":"R-HSA-5654743","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by FGFR2 in disease","react_pathway_id":"R-HSA-5655253","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by FGFR4 in disease","react_pathway_id":"R-HSA-5655291","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by FGFR1 in disease","react_pathway_id":"R-HSA-5655302","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by FGFR3 in disease","react_pathway_id":"R-HSA-5655332","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS","PSMD14"],"pathway_name":"Regulation of RAS by GAPs","react_pathway_id":"R-HSA-5658442","source":"CTD"},{"inference_gene_symbol":["IL1B","RELA"],"pathway_name":"CLEC7A/inflammasome pathway","react_pathway_id":"R-HSA-5660668","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","MYC","NRAS","PSMD14","PTPN11"],"pathway_name":"Diseases of signal transduction","react_pathway_id":"R-HSA-5663202","source":"CTD"},{"inference_gene_symbol":["MET","PSMD14"],"pathway_name":"Infectious disease","react_pathway_id":"R-HSA-5663205","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","PSMD14","TNF"],"pathway_name":"TNFR2 non-canonical NF-kB pathway","react_pathway_id":"R-HSA-5668541","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"RAF activation","react_pathway_id":"R-HSA-5673000","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"RAF/MAP kinase cascade","react_pathway_id":"R-HSA-5673001","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"MAP2K and MAPK activation","react_pathway_id":"R-HSA-5674135","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Negative regulation of MAPK pathway","react_pathway_id":"R-HSA-5675221","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","TNFSF10"],"pathway_name":"Regulation of necroptotic cell death","react_pathway_id":"R-HSA-5675482","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"NIK-->noncanonical NF-kB signaling","react_pathway_id":"R-HSA-5676590","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3"],"pathway_name":"TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway","react_pathway_id":"R-HSA-5676594","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Defective CFTR causes cystic fibrosis","react_pathway_id":"R-HSA-5678895","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","IGF2BP1","KRAS","MET","MYC","NRAS","PSMD14","PTPN11"],"pathway_name":"MAPK family signaling cascades","react_pathway_id":"R-HSA-5683057","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"MAPK1/MAPK3 signaling","react_pathway_id":"R-HSA-5684996","source":"CTD"},{"inference_gene_symbol":"BARD1","pathway_name":"HDR through Single Strand Annealing (SSA)","react_pathway_id":"R-HSA-5685938","source":"CTD"},{"inference_gene_symbol":"BARD1","pathway_name":"HDR through Homologous Recombination (HRR)","react_pathway_id":"R-HSA-5685942","source":"CTD"},{"inference_gene_symbol":["IGF2BP1","MYC","PSMD14"],"pathway_name":"MAPK6/MAPK4 signaling","react_pathway_id":"R-HSA-5687128","source":"CTD"},{"inference_gene_symbol":["BARD1","BIRC2","BIRC3","ESR1","GATA3","MYC","PSMD14"],"pathway_name":"Deubiquitination","react_pathway_id":"R-HSA-5688426","source":"CTD"},{"inference_gene_symbol":["BARD1","PSMD14"],"pathway_name":"UCH proteinases","react_pathway_id":"R-HSA-5689603","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","GATA3","MYC","PSMD14"],"pathway_name":"Ub-specific processing proteases","react_pathway_id":"R-HSA-5689880","source":"CTD"},{"inference_gene_symbol":"ESR1","pathway_name":"Ovarian tumor domain proteases","react_pathway_id":"R-HSA-5689896","source":"CTD"},{"inference_gene_symbol":["BARD1","PSMD14"],"pathway_name":"Metalloprotease DUBs","react_pathway_id":"R-HSA-5689901","source":"CTD"},{"inference_gene_symbol":["BARD1","CHEK2"],"pathway_name":"DNA Double-Strand Break Repair","react_pathway_id":"R-HSA-5693532","source":"CTD"},{"inference_gene_symbol":"BARD1","pathway_name":"Resolution of D-Loop Structures","react_pathway_id":"R-HSA-5693537","source":"CTD"},{"inference_gene_symbol":"BARD1","pathway_name":"Homology Directed Repair","react_pathway_id":"R-HSA-5693538","source":"CTD"},{"inference_gene_symbol":"BARD1","pathway_name":"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)","react_pathway_id":"R-HSA-5693554","source":"CTD"},{"inference_gene_symbol":["BARD1","CHEK2"],"pathway_name":"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks","react_pathway_id":"R-HSA-5693565","source":"CTD"},{"inference_gene_symbol":"BARD1","pathway_name":"HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)","react_pathway_id":"R-HSA-5693567","source":"CTD"},{"inference_gene_symbol":"BARD1","pathway_name":"Resolution of D-loop Structures through Holliday Junction Intermediates","react_pathway_id":"R-HSA-5693568","source":"CTD"},{"inference_gene_symbol":"BARD1","pathway_name":"Nonhomologous End-Joining (NHEJ)","react_pathway_id":"R-HSA-5693571","source":"CTD"},{"inference_gene_symbol":"BARD1","pathway_name":"Homologous DNA Pairing and Strand Exchange","react_pathway_id":"R-HSA-5693579","source":"CTD"},{"inference_gene_symbol":["BARD1","CHEK2"],"pathway_name":"DNA Double Strand Break Response","react_pathway_id":"R-HSA-5693606","source":"CTD"},{"inference_gene_symbol":"BARD1","pathway_name":"Processing of DNA double-strand break ends","react_pathway_id":"R-HSA-5693607","source":"CTD"},{"inference_gene_symbol":"BARD1","pathway_name":"Presynaptic phase of homologous DNA pairing and strand exchange","react_pathway_id":"R-HSA-5693616","source":"CTD"},{"inference_gene_symbol":["AURKA","BARD1","BIRC2","BIRC3","CDKN2A","ESR1","GATA3","MYC","PSMD14"],"pathway_name":"Post-translational protein modification","react_pathway_id":"R-HSA-597592","source":"CTD"},{"inference_gene_symbol":"COX2","pathway_name":"Respiratory electron transport","react_pathway_id":"R-HSA-611105","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Interleukin-6 family signaling","react_pathway_id":"R-HSA-6783589","source":"CTD"},{"inference_gene_symbol":["IL1B","TNF"],"pathway_name":"Interleukin-10 signaling","react_pathway_id":"R-HSA-6783783","source":"CTD"},{"inference_gene_symbol":["GATA3","HGF","IL1B","MMP9","MYC","TNF"],"pathway_name":"Interleukin-4 and 13 signaling","react_pathway_id":"R-HSA-6785807","source":"CTD"},{"inference_gene_symbol":"AURKA","pathway_name":"TP53 Regulates Transcription of Cell Cycle Genes","react_pathway_id":"R-HSA-6791312","source":"CTD"},{"inference_gene_symbol":["CD44","MMP9","NRAS","PSMD14"],"pathway_name":"Neutrophil degranulation","react_pathway_id":"R-HSA-6798695","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by moderate kinase activity BRAF mutants","react_pathway_id":"R-HSA-6802946","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by high-kinase activity BRAF mutants","react_pathway_id":"R-HSA-6802948","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by RAS mutants","react_pathway_id":"R-HSA-6802949","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by BRAF and RAF fusions","react_pathway_id":"R-HSA-6802952","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"RAS signaling downstream of NF1 loss-of-function variants","react_pathway_id":"R-HSA-6802953","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Paradoxical activation of RAF signaling by kinase inactive BRAF","react_pathway_id":"R-HSA-6802955","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Oncogenic MAPK signaling","react_pathway_id":"R-HSA-6802957","source":"CTD"},{"inference_gene_symbol":"AURKA","pathway_name":"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","react_pathway_id":"R-HSA-6804114","source":"CTD"},{"inference_gene_symbol":["AURKA","BARD1","CHEK2"],"pathway_name":"Regulation of TP53 Activity through Phosphorylation","react_pathway_id":"R-HSA-6804756","source":"CTD"},{"inference_gene_symbol":["CDKN2A","CHEK2"],"pathway_name":"Regulation of TP53 Degradation","react_pathway_id":"R-HSA-6804757","source":"CTD"},{"inference_gene_symbol":"CHEK2","pathway_name":"Regulation of TP53 Activity through Methylation","react_pathway_id":"R-HSA-6804760","source":"CTD"},{"inference_gene_symbol":["CDKN2A","CHEK2"],"pathway_name":"Regulation of TP53 Expression and Degradation","react_pathway_id":"R-HSA-6806003","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PTPN11"],"pathway_name":"Signaling by MET","react_pathway_id":"R-HSA-6806834","source":"CTD"},{"inference_gene_symbol":["HGF","MET"],"pathway_name":"MET Receptor Activation","react_pathway_id":"R-HSA-6806942","source":"CTD"},{"inference_gene_symbol":["HGF","MET"],"pathway_name":"Negative regulation of MET activity","react_pathway_id":"R-HSA-6807004","source":"CTD"},{"inference_gene_symbol":"KIF1B","pathway_name":"COPI-dependent Golgi-to-ER retrograde traffic","react_pathway_id":"R-HSA-6811434","source":"CTD"},{"inference_gene_symbol":"KIF1B","pathway_name":"Intra-Golgi and retrograde Golgi-to-ER traffic","react_pathway_id":"R-HSA-6811442","source":"CTD"},{"inference_gene_symbol":["HGF","MET","PTPN11"],"pathway_name":"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling","react_pathway_id":"R-HSA-6811558","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"CDT1 association with the CDC6:ORC:origin complex","react_pathway_id":"R-HSA-68827","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Assembly of the pre-replicative complex","react_pathway_id":"R-HSA-68867","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"M/G1 Transition","react_pathway_id":"R-HSA-68874","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Mitotic Anaphase","react_pathway_id":"R-HSA-68882","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"M Phase","react_pathway_id":"R-HSA-68886","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Orc1 removal from chromatin","react_pathway_id":"R-HSA-68949","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"DNA Replication Pre-Initiation","react_pathway_id":"R-HSA-69002","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"CDK-mediated phosphorylation and removal of Cdc6","react_pathway_id":"R-HSA-69017","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Switching of origins to a post-replicative state","react_pathway_id":"R-HSA-69052","source":"CTD"},{"inference_gene_symbol":["MYC","PSMD14"],"pathway_name":"Cyclin E associated events during G1/S transition","react_pathway_id":"R-HSA-69202","source":"CTD"},{"inference_gene_symbol":["MYC","PSMD14"],"pathway_name":"G1/S Transition","react_pathway_id":"R-HSA-69206","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Ubiquitin-dependent degradation of Cyclin D1","react_pathway_id":"R-HSA-69229","source":"CTD"},{"inference_gene_symbol":"CDKN2A","pathway_name":"Cyclin D associated events in G1","react_pathway_id":"R-HSA-69231","source":"CTD"},{"inference_gene_symbol":"CDKN2A","pathway_name":"G1 Phase","react_pathway_id":"R-HSA-69236","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Synthesis of DNA","react_pathway_id":"R-HSA-69239","source":"CTD"},{"inference_gene_symbol":["MYC","PSMD14"],"pathway_name":"S Phase","react_pathway_id":"R-HSA-69242","source":"CTD"},{"inference_gene_symbol":["AURKA","PSMD14"],"pathway_name":"G2/M Transition","react_pathway_id":"R-HSA-69275","source":"CTD"},{"inference_gene_symbol":["AURKA","CDKN2A","MYC","PSMD14"],"pathway_name":"Cell Cycle, Mitotic","react_pathway_id":"R-HSA-69278","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Removal of licensing factors from origins","react_pathway_id":"R-HSA-69300","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Regulation of DNA replication","react_pathway_id":"R-HSA-69304","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"DNA Replication","react_pathway_id":"R-HSA-69306","source":"CTD"},{"inference_gene_symbol":"TNFSF10","pathway_name":"Dimerization of procaspase-8","react_pathway_id":"R-HSA-69416","source":"CTD"},{"inference_gene_symbol":["BARD1","CHEK2"],"pathway_name":"G2/M DNA damage checkpoint","react_pathway_id":"R-HSA-69473","source":"CTD"},{"inference_gene_symbol":["BARD1","CHEK2","PSMD14"],"pathway_name":"G2/M Checkpoints","react_pathway_id":"R-HSA-69481","source":"CTD"},{"inference_gene_symbol":["CHEK2","PSMD14"],"pathway_name":"Stabilization of p53","react_pathway_id":"R-HSA-69541","source":"CTD"},{"inference_gene_symbol":["CHEK2","PSMD14"],"pathway_name":"p53-Dependent G1 DNA Damage Response","react_pathway_id":"R-HSA-69563","source":"CTD"},{"inference_gene_symbol":["CHEK2","PSMD14"],"pathway_name":"p53-Dependent G1/S DNA damage checkpoint","react_pathway_id":"R-HSA-69580","source":"CTD"},{"inference_gene_symbol":["CHEK2","PSMD14"],"pathway_name":"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A","react_pathway_id":"R-HSA-69601","source":"CTD"},{"inference_gene_symbol":["CHEK2","PSMD14"],"pathway_name":"p53-Independent DNA Damage Response","react_pathway_id":"R-HSA-69610","source":"CTD"},{"inference_gene_symbol":["CHEK2","PSMD14"],"pathway_name":"p53-Independent G1/S DNA damage checkpoint","react_pathway_id":"R-HSA-69613","source":"CTD"},{"inference_gene_symbol":["CHEK2","PSMD14"],"pathway_name":"G1/S DNA Damage Checkpoints","react_pathway_id":"R-HSA-69615","source":"CTD"},{"inference_gene_symbol":["BARD1","CHEK2","PSMD14"],"pathway_name":"Cell Cycle Checkpoints","react_pathway_id":"R-HSA-69620","source":"CTD"},{"inference_gene_symbol":["MYC","PSMD14"],"pathway_name":"Cyclin A:Cdk2-associated events at S phase entry","react_pathway_id":"R-HSA-69656","source":"CTD"},{"inference_gene_symbol":["DBH","PSMD14","TH"],"pathway_name":"Metabolism of amino acids and derivatives","react_pathway_id":"R-HSA-71291","source":"CTD"},{"inference_gene_symbol":"CD44","pathway_name":"Metabolism of carbohydrates","react_pathway_id":"R-HSA-71387","source":"CTD"},{"inference_gene_symbol":"NT5E","pathway_name":"Pyrimidine catabolism","react_pathway_id":"R-HSA-73621","source":"CTD"},{"inference_gene_symbol":"NT5E","pathway_name":"Purine metabolism","react_pathway_id":"R-HSA-73847","source":"CTD"},{"inference_gene_symbol":"NT5E","pathway_name":"Pyrimidine metabolism","react_pathway_id":"R-HSA-73848","source":"CTD"},{"inference_gene_symbol":"TERT","pathway_name":"Chromosome Maintenance","react_pathway_id":"R-HSA-73886","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","TNF","TNFSF10"],"pathway_name":"Death Receptor Signalling","react_pathway_id":"R-HSA-73887","source":"CTD"},{"inference_gene_symbol":["BARD1","CHEK2"],"pathway_name":"DNA Repair","react_pathway_id":"R-HSA-73894","source":"CTD"},{"inference_gene_symbol":["AURKA","BARD1","CDKN2A","CHEK2","COX2","ESR1","IGF2BP1","MYC","PSMD14","YAP1"],"pathway_name":"Gene Expression","react_pathway_id":"R-HSA-74160","source":"CTD"},{"inference_gene_symbol":"NT5E","pathway_name":"Purine catabolism","react_pathway_id":"R-HSA-74259","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"Insulin receptor signalling cascade","react_pathway_id":"R-HSA-74751","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"Signaling by Insulin receptor","react_pathway_id":"R-HSA-74752","source":"CTD"},{"inference_gene_symbol":"BIRC2","pathway_name":"Apoptotic execution  phase","react_pathway_id":"R-HSA-75153","source":"CTD"},{"inference_gene_symbol":"TNFSF10","pathway_name":"TRAIL  signaling","react_pathway_id":"R-HSA-75158","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"Ubiquitin-dependent degradation of Cyclin D","react_pathway_id":"R-HSA-75815","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","TNF"],"pathway_name":"TNF signaling","react_pathway_id":"R-HSA-75893","source":"CTD"},{"inference_gene_symbol":["HGF","PTPN11"],"pathway_name":"Platelet activation, signaling and aggregation","react_pathway_id":"R-HSA-76002","source":"CTD"},{"inference_gene_symbol":"HGF","pathway_name":"Response to elevated platelet cytosolic Ca2+","react_pathway_id":"R-HSA-76005","source":"CTD"},{"inference_gene_symbol":["CD44","PTPN11"],"pathway_name":"Interferon gamma signaling","react_pathway_id":"R-HSA-877300","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Regulation of IFNG signaling","react_pathway_id":"R-HSA-877312","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"Gastrin-CREB signalling pathway via PKC and MAPK","react_pathway_id":"R-HSA-881907","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by PTK6","react_pathway_id":"R-HSA-8848021","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases","react_pathway_id":"R-HSA-8849471","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS"],"pathway_name":"MET activates RAS signaling","react_pathway_id":"R-HSA-8851805","source":"CTD"},{"inference_gene_symbol":["HGF","MET"],"pathway_name":"MET activates PI3K/AKT signaling","react_pathway_id":"R-HSA-8851907","source":"CTD"},{"inference_gene_symbol":"PSMD14","pathway_name":"The role of GTSE1 in G2/M progression after G2 checkpoint","react_pathway_id":"R-HSA-8852276","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by FGFR3 fusions in cancer","react_pathway_id":"R-HSA-8853334","source":"CTD"},{"inference_gene_symbol":["HRAS","KRAS","NRAS"],"pathway_name":"Signaling by FGFR3 point mutants in cancer","react_pathway_id":"R-HSA-8853338","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11"],"pathway_name":"RET signaling","react_pathway_id":"R-HSA-8853659","source":"CTD"},{"inference_gene_symbol":["AURKA","PSMD14"],"pathway_name":"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis","react_pathway_id":"R-HSA-8854050","source":"CTD"},{"inference_gene_symbol":"AURKA","pathway_name":"AURKA Activation by TPX2","react_pathway_id":"R-HSA-8854518","source":"CTD"},{"inference_gene_symbol":"AURKA","pathway_name":"Interaction between PHLDA1 and AURKA","react_pathway_id":"R-HSA-8854521","source":"CTD"},{"inference_gene_symbol":"KIF1B","pathway_name":"Golgi-to-ER retrograde transport","react_pathway_id":"R-HSA-8856688","source":"CTD"},{"inference_gene_symbol":["ESR1","MYC"],"pathway_name":"Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","react_pathway_id":"R-HSA-8864260","source":"CTD"},{"inference_gene_symbol":["HGF","MET","PTPN11"],"pathway_name":"MET activates PTPN11","react_pathway_id":"R-HSA-8865999","source":"CTD"},{"inference_gene_symbol":"ESR1","pathway_name":"TFAP2 (AP-2) family regulates transcription of growth factors and their receptors","react_pathway_id":"R-HSA-8866910","source":"CTD"},{"inference_gene_symbol":"MYC","pathway_name":"TFAP2 (AP-2) family regulates transcription of cell cycle factors","react_pathway_id":"R-HSA-8866911","source":"CTD"},{"inference_gene_symbol":["HGF","MET"],"pathway_name":"MET activates PTK2 signaling","react_pathway_id":"R-HSA-8874081","source":"CTD"},{"inference_gene_symbol":"MET","pathway_name":"InlB-mediated entry of Listeria monocytogenes into host cell","react_pathway_id":"R-HSA-8875360","source":"CTD"},{"inference_gene_symbol":["HGF","MET"],"pathway_name":"MET interacts with TNS proteins","react_pathway_id":"R-HSA-8875513","source":"CTD"},{"inference_gene_symbol":["HGF","MET"],"pathway_name":"MET activates RAP1 and RAC1","react_pathway_id":"R-HSA-8875555","source":"CTD"},{"inference_gene_symbol":["HGF","MET"],"pathway_name":"MET receptor recycling","react_pathway_id":"R-HSA-8875656","source":"CTD"},{"inference_gene_symbol":["HGF","MET"],"pathway_name":"MET activates STAT3","react_pathway_id":"R-HSA-8875791","source":"CTD"},{"inference_gene_symbol":["HGF","MET"],"pathway_name":"MET promotes cell motility","react_pathway_id":"R-HSA-8875878","source":"CTD"},{"inference_gene_symbol":"MET","pathway_name":"Listeria monocytogenes entry into host cells","react_pathway_id":"R-HSA-8876384","source":"CTD"},{"inference_gene_symbol":["IFNB1","PTPN11"],"pathway_name":"Interferon alpha/beta signaling","react_pathway_id":"R-HSA-909733","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14"],"pathway_name":"Interleukin receptor SHC signaling","react_pathway_id":"R-HSA-912526","source":"CTD"},{"inference_gene_symbol":["IFNB1","PTPN11"],"pathway_name":"Regulation of IFNA signaling","react_pathway_id":"R-HSA-912694","source":"CTD"},{"inference_gene_symbol":["CD44","IFNB1","PTPN11"],"pathway_name":"Interferon Signaling","react_pathway_id":"R-HSA-913531","source":"CTD"},{"inference_gene_symbol":"IFNB1","pathway_name":"TRAF3-dependent IRF activation pathway","react_pathway_id":"R-HSA-918233","source":"CTD"},{"inference_gene_symbol":"IFNB1","pathway_name":"TRAF6 mediated IRF7 activation","react_pathway_id":"R-HSA-933541","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"TRAF6 mediated NF-kB activation","react_pathway_id":"R-HSA-933542","source":"CTD"},{"inference_gene_symbol":"PTPN11","pathway_name":"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","react_pathway_id":"R-HSA-936964","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3"],"pathway_name":"IKK complex recruitment mediated by RIP1","react_pathway_id":"R-HSA-937041","source":"CTD"},{"inference_gene_symbol":["BIRC2","BIRC3","PTPN11","RELA"],"pathway_name":"TRIF-mediated TLR3/TLR4 signaling","react_pathway_id":"R-HSA-937061","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation","react_pathway_id":"R-HSA-975138","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"MyD88 dependent cascade initiated on endosome","react_pathway_id":"R-HSA-975155","source":"CTD"},{"inference_gene_symbol":"RELA","pathway_name":"MyD88 cascade initiated on plasma membrane","react_pathway_id":"R-HSA-975871","source":"CTD"},{"inference_gene_symbol":["HACE1","PSMD14"],"pathway_name":"Antigen processing: Ubiquitination & Proteasome degradation","react_pathway_id":"R-HSA-983168","source":"CTD"},{"inference_gene_symbol":["HACE1","PSMD14"],"pathway_name":"Class I MHC mediated antigen processing & presentation","react_pathway_id":"R-HSA-983169","source":"CTD"},{"inference_gene_symbol":"KIF1B","pathway_name":"Kinesins","react_pathway_id":"R-HSA-983189","source":"CTD"},{"inference_gene_symbol":["DOCK8","GATA3","IFNB1","KIF1B","MYB"],"pathway_name":"Factors involved in megakaryocyte development and platelet production","react_pathway_id":"R-HSA-983231","source":"CTD"},{"inference_gene_symbol":["HGF","HRAS","KRAS","MET","NRAS","PSMD14","PTPN11","RELA"],"pathway_name":"Signaling by the B Cell Receptor (BCR)","react_pathway_id":"R-HSA-983705","source":"CTD"}]},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:2621","DOID:3093","DOID:7","DOID:4","DOID:574","DOID:162","DOID:863","DOID:1192","DOID:14566","DOID:0050686"],"children":["DOID:371","DOID:4160","DOID:4163"],"def":"\"An autonomic nervous system neoplasm that derives_from immature nerve cells.\" [url:http\\://www.cancer.gov/cancertopics/types/neuroblastoma]","descendants":["DOID:5195","DOID:5193","DOID:4160","DOID:0050935","DOID:4163","DOID:7949","DOID:5194","DOID:7951","DOID:371"],"doid":"DOID:769","name":"neuroblastoma","parents":["DOID:2621"],"synonyms":{},"xrefs":{"efo":"0000621","gard":"7185","icdo":"9500/3","mesh":"D009447","ncit":"C3270","ordo":"635","snomedct_us_2025_09_01":"432328008","umls_cui":"C0027819"}},"hpo":{"disease_name":"Neuroblastoma","orphanet":"635","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0003006","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0004375","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0011976","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001824","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001873","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001903","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001945","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002028","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002716","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0003270","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0003334","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0012378","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0031500","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000520","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0000737","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001017","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001482","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001892","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001928","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002098","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002176","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002277","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002653","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002756","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0003281","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0011977","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0011978","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0025435","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0031955","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0000822","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001251","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001336","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0010543","orphanet_refs":"orphanet:635"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0025553","orphanet_refs":"orphanet:635"}]},"mondo":{"ancestors":["MONDO:0000001","MONDO:0045024","MONDO:0021248","MONDO:7770007","MONDO:0021635","MONDO:0005462","MONDO:0021147","MONDO:0005564","MONDO:0021193","MONDO:7770008","MONDO:0005070","MONDO:0005071","MONDO:0006316","MONDO:7770006","MONDO:0023370","MONDO:0700096"],"children":["MONDO:0000551","MONDO:0001095","MONDO:0002749","MONDO:0002899","MONDO:0002900","MONDO:0005598","MONDO:0024340"],"definition":"Neuroblastoma (NB) is the most common solid, extracranial childhood tumor. It is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system. [PMID:32903387]","descendants":["MONDO:0859597","MONDO:0006076","MONDO:0001129","MONDO:0024340","MONDO:0006329","MONDO:0002899","MONDO:0002749","MONDO:0001095","MONDO:0002900","MONDO:0004477","MONDO:0001096","MONDO:0000551","MONDO:0004024","MONDO:0000549","MONDO:0005598"],"disease_arises_from_structure":{"cl":["CL:0000031"]},"excluded_subClassOf":{"mondo":["MONDO:0002366"]},"label":"neuroblastoma","mondo":"MONDO:0005072","parents":["MONDO:0006316","MONDO:0021635"],"synonym":{"exact":["neural Crest tumor, malignant","neuroblastoma","neuroblastoma (Schwannian Stroma-poor)","neuroblastoma, malignant"],"related":["NB"]},"xrefs":{"birnlex":["12631"],"doid":["DOID:769"],"efo":["EFO:0000621"],"gard":["0007185"],"icdo":["9500/3"],"meddra":["10029260"],"medgen":["18012"],"mesh":["D009447"],"nando":["2200040"],"ncit":["C3270"],"oncotree":["NBL"],"orphanet":["635"],"sctid":["432328008"],"umls":["C0027819"]}},"original_id":["orphanet:635","UMLS:C0700095"],"umls":[{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10am":{"preferred":"M9500/3"},"mesh":{"preferred":"D009447"},"nci":{"non-preferred":"C3270","preferred":"C3270"},"snomed":{"non-preferred":["87364003","269507008","189931003","432328008"],"preferred":["432328008","87364003"]},"umls":"C0027819"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","nci":{"non-preferred":"C186547","preferred":"C186547"},"snomed":{"preferred":"87364003"},"umls":"C0700095"}]}