{"_id":"MONDO:0004976","_version":1,"ctd":{"chemical_related_to_disease":[{"chemical_name":"2,2',4,4'-tetrabromodiphenyl ether","direct_evidence":"marker/mechanism","mesh_chemical_id":"C511295","pubmed":"27159543","source":"CTD"},{"cas_registry_number":"138847-85-5","chemical_name":"2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate","direct_evidence":"therapeutic","mesh_chemical_id":"C071738","pubmed":"24885036","source":"CTD"},{"cas_registry_number":"4170-30-3","chemical_name":"2-butenal","direct_evidence":"marker/mechanism","mesh_chemical_id":"C012796","pubmed":"17319283","source":"CTD"},{"cas_registry_number":"74509-14-1","chemical_name":"2-formyl-5-(hydroxymethyl)pyrrole-1-norleucine","direct_evidence":"marker/mechanism","mesh_chemical_id":"C059571","pubmed":"10965797","source":"CTD"},{"chemical_name":"3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine","direct_evidence":"therapeutic","mesh_chemical_id":"C099630","pubmed":"21867702","source":"CTD"},{"cas_registry_number":"29343-52-0","chemical_name":"4-hydroxy-2-nonenal","direct_evidence":"marker/mechanism","mesh_chemical_id":"C027576","pubmed":"10965797","source":"CTD"},{"cas_registry_number":"39277-47-9","chemical_name":"Agent Orange","direct_evidence":"marker/mechanism","mesh_chemical_id":"D000075182","pubmed":"26923711","source":"CTD"},{"chemical_name":"Agrochemicals","direct_evidence":"marker/mechanism","mesh_chemical_id":"D016573","pubmed":"29852480","source":"CTD"},{"chemical_name":"Air Pollutants","direct_evidence":"marker/mechanism","mesh_chemical_id":"D000393","pubmed":["25544309","38970158"],"source":"CTD"},{"cas_registry_number":"7429-90-5","chemical_name":"Aluminum","direct_evidence":"marker/mechanism","mesh_chemical_id":"D000535","pubmed":["1817796","28337565"],"source":"CTD"},{"chemical_name":"Aluminum Chloride","direct_evidence":"marker/mechanism","mesh_chemical_id":"D000077410","pubmed":"1933693","source":"CTD"},{"cas_registry_number":"50-48-6","chemical_name":"Amitriptyline","direct_evidence":"marker/mechanism","mesh_chemical_id":"D000639","pubmed":"2108779","source":"CTD"},{"chemical_name":"Anticonvulsants","direct_evidence":"marker/mechanism","mesh_chemical_id":"D000927","pubmed":"27561959","source":"CTD"},{"cas_registry_number":"7440-38-2","chemical_name":"Arsenic","direct_evidence":"marker/mechanism","mesh_chemical_id":"D001151","pubmed":"28337565","source":"CTD"},{"cas_registry_number":"50-78-2","chemical_name":"Aspirin","direct_evidence":"therapeutic","mesh_chemical_id":"D001241","pubmed":"25721071","source":"CTD"},{"chemical_name":"Atorvastatin","direct_evidence":"marker/mechanism","mesh_chemical_id":"D000069059","pubmed":"29427042","source":"CTD"},{"cas_registry_number":"71-43-2","chemical_name":"Benzene","direct_evidence":"marker/mechanism","mesh_chemical_id":"D001554","pubmed":"32193761","source":"CTD"},{"chemical_name":"beta-N-methylamino-L-alanine","direct_evidence":"marker/mechanism","mesh_chemical_id":"C001824","pubmed":["23246360","30090328"],"source":"CTD"},{"chemical_name":"beta-N-methylamino-L-alanine","direct_evidence":"therapeutic","mesh_chemical_id":"C001824","pubmed":"29434186","source":"CTD"},{"cas_registry_number":"25614-03-3","chemical_name":"Bromocriptine","direct_evidence":"therapeutic","mesh_chemical_id":"D001971","pubmed":"21867702","source":"CTD"},{"cas_registry_number":"7440-70-2","chemical_name":"Calcium","direct_evidence":"marker/mechanism","mesh_chemical_id":"D002118","pubmed":"1817796","source":"CTD"},{"cas_registry_number":"12789-03-6","chemical_name":"Chlordan","direct_evidence":"marker/mechanism","mesh_chemical_id":"D002706","pubmed":"27159543","source":"CTD"},{"cas_registry_number":"57-88-5","chemical_name":"Cholesterol","direct_evidence":"marker/mechanism","mesh_chemical_id":"D002784","pubmed":"24919836","source":"CTD"},{"cas_registry_number":"6104-58-1","chemical_name":"coomassie Brilliant Blue","direct_evidence":"therapeutic","mesh_chemical_id":"C004692","pubmed":"23583883","source":"CTD"},{"cas_registry_number":"7440-50-8","chemical_name":"Copper","direct_evidence":"marker/mechanism","mesh_chemical_id":"D003300","pubmed":"10694572","source":"CTD"},{"chemical_name":"Cyanobacteria Toxins","direct_evidence":"marker/mechanism","mesh_chemical_id":"D000087522","pubmed":["23246360","24703731"],"source":"CTD"},{"chemical_name":"Cytokines","direct_evidence":"marker/mechanism","mesh_chemical_id":"D016207","pubmed":"28532674","source":"CTD"},{"chemical_name":"Defoliants, Chemical","direct_evidence":"marker/mechanism","mesh_chemical_id":"D003678","pubmed":"26923711","source":"CTD"},{"cas_registry_number":"25167-62-8","chemical_name":"Docosahexaenoic Acids","direct_evidence":"marker/mechanism","mesh_chemical_id":"D004281","pubmed":"26805387","source":"CTD"},{"chemical_name":"Dronabinol","direct_evidence":"therapeutic","mesh_chemical_id":"D013759","pubmed":"15204022","source":"CTD"},{"chemical_name":"Drugs, Chinese Herbal","direct_evidence":"therapeutic","mesh_chemical_id":"D004365","pubmed":"29374221","source":"CTD"},{"cas_registry_number":"89-25-8","chemical_name":"Edaravone","direct_evidence":"therapeutic","mesh_chemical_id":"D000077553","pubmed":["28522181","28872920","29937981","31364409"],"source":"CTD"},{"chemical_name":"Fertilizers","direct_evidence":"marker/mechanism","mesh_chemical_id":"D005308","pubmed":"24979055","source":"CTD"},{"chemical_name":"Flame Retardants","direct_evidence":"marker/mechanism","mesh_chemical_id":"D005411","pubmed":"27159543","source":"CTD"},{"cas_registry_number":"50-00-0","chemical_name":"Formaldehyde","direct_evidence":"marker/mechanism","mesh_chemical_id":"D005557","pubmed":["27418175","28585120"],"source":"CTD"},{"chemical_name":"Herbicides","direct_evidence":"marker/mechanism","mesh_chemical_id":"D006540","pubmed":"22521219","source":"CTD"},{"chemical_name":"Hydrocarbons, Aromatic","direct_evidence":"marker/mechanism","mesh_chemical_id":"D006841","pubmed":"25544309","source":"CTD"},{"chemical_name":"Hydrocarbons, Chlorinated","direct_evidence":"marker/mechanism","mesh_chemical_id":"D006843","pubmed":"22521219","source":"CTD"},{"chemical_name":"imidazolone","direct_evidence":"marker/mechanism","mesh_chemical_id":"C117197","pubmed":"10965797","source":"CTD"},{"chemical_name":"kenpaullone","direct_evidence":"therapeutic","mesh_chemical_id":"C119620","pubmed":"23602540","source":"CTD"},{"cas_registry_number":"7439-92-1","chemical_name":"Lead","direct_evidence":"marker/mechanism","mesh_chemical_id":"D007854","pubmed":["20406759","27377857","28122372"],"source":"CTD"},{"cas_registry_number":"191732-72-6","chemical_name":"Lenalidomide","direct_evidence":"therapeutic","mesh_chemical_id":"D000077269","pubmed":"16510725","source":"CTD"},{"chemical_name":"Levodopa","direct_evidence":"therapeutic","mesh_chemical_id":"D007980","pubmed":["14962622","4743883"],"source":"CTD"},{"cas_registry_number":"7439-93-2","chemical_name":"Lithium","direct_evidence":"therapeutic","mesh_chemical_id":"D008094","pubmed":"18250315","source":"CTD"},{"cas_registry_number":"75330-75-5","chemical_name":"Lovastatin","direct_evidence":"marker/mechanism","mesh_chemical_id":"D008148","pubmed":"29427042","source":"CTD"},{"chemical_name":"Lysophosphatidylcholines","direct_evidence":"marker/mechanism","mesh_chemical_id":"D008244","pubmed":"24919836","source":"CTD"},{"cas_registry_number":"7439-96-5","chemical_name":"Manganese","direct_evidence":"marker/mechanism","mesh_chemical_id":"D008345","pubmed":["1817796","28337565"],"source":"CTD"},{"cas_registry_number":"73-31-4","chemical_name":"Melatonin","direct_evidence":"therapeutic","mesh_chemical_id":"D008550","pubmed":"17014688","source":"CTD"},{"cas_registry_number":"7439-97-6","chemical_name":"Mercury","direct_evidence":"marker/mechanism","mesh_chemical_id":"D008628","pubmed":"27377857","source":"CTD"},{"chemical_name":"Metals, Heavy","direct_evidence":"marker/mechanism","mesh_chemical_id":"D019216","pubmed":"28122372","source":"CTD"},{"cas_registry_number":"75-09-2","chemical_name":"Methylene Chloride","direct_evidence":"marker/mechanism","mesh_chemical_id":"D008752","pubmed":["27418175","32193761"],"source":"CTD"},{"cas_registry_number":"10118-90-8","chemical_name":"Minocycline","direct_evidence":"therapeutic","mesh_chemical_id":"D008911","pubmed":["15159491","15964487","17406652"],"source":"CTD"},{"chemical_name":"Nitrates","direct_evidence":"marker/mechanism","mesh_chemical_id":"D009566","pubmed":"18307039","source":"CTD"},{"cas_registry_number":"10102-43-9","chemical_name":"Nitric Oxide","direct_evidence":"marker/mechanism","mesh_chemical_id":"D009569","pubmed":"29852480","source":"CTD"},{"chemical_name":"Nitrites","direct_evidence":"marker/mechanism","mesh_chemical_id":"D009573","pubmed":"18307039","source":"CTD"},{"cas_registry_number":"10102-44-0","chemical_name":"Nitrogen Dioxide","direct_evidence":"marker/mechanism","mesh_chemical_id":"D009585","pubmed":"29852480","source":"CTD"},{"chemical_name":"Nitrogen Oxides","direct_evidence":"marker/mechanism","mesh_chemical_id":"D009589","pubmed":"38970158","source":"CTD"},{"cas_registry_number":"72-69-5","chemical_name":"Nortriptyline","direct_evidence":"therapeutic","mesh_chemical_id":"D009661","pubmed":"17686041","source":"CTD"},{"chemical_name":"olesoxime","direct_evidence":"therapeutic","mesh_chemical_id":"C522838","pubmed":["17496168","20721828"],"source":"CTD"},{"chemical_name":"Organophosphates","direct_evidence":"marker/mechanism","mesh_chemical_id":"D010755","pubmed":"28070599","source":"CTD"},{"chemical_name":"P7C3 compound","direct_evidence":"therapeutic","mesh_chemical_id":"C552520","pubmed":"23027932","source":"CTD"},{"chemical_name":"Particulate Matter","direct_evidence":"marker/mechanism","mesh_chemical_id":"D052638","pubmed":"38970158","source":"CTD"},{"cas_registry_number":"608-93-5","chemical_name":"pentachlorobenzene","direct_evidence":"marker/mechanism","mesh_chemical_id":"C003060","pubmed":"27159543","source":"CTD"},{"chemical_name":"Pesticides","direct_evidence":"marker/mechanism","mesh_chemical_id":"D010575","pubmed":["22521219","22819005","24979055","27159543","27377857","28122372"],"source":"CTD"},{"chemical_name":"Polychlorinated Biphenyls","direct_evidence":"marker/mechanism","mesh_chemical_id":"D011078","pubmed":"27159543","source":"CTD"},{"cas_registry_number":"81093-37-0","chemical_name":"Pravastatin","direct_evidence":"marker/mechanism","mesh_chemical_id":"D017035","pubmed":"29427042","source":"CTD"},{"cas_registry_number":"60-87-7","chemical_name":"Promethazine","direct_evidence":"therapeutic","mesh_chemical_id":"D011398","pubmed":"17686041","source":"CTD"},{"chemical_name":"Pyrethrins","direct_evidence":"marker/mechanism","mesh_chemical_id":"D011722","pubmed":"22521219","source":"CTD"},{"chemical_name":"Radium","direct_evidence":"marker/mechanism","mesh_chemical_id":"D011883","pubmed":"26923711","source":"CTD"},{"chemical_name":"Reactive Nitrogen Species","direct_evidence":"marker/mechanism","mesh_chemical_id":"D026361","pubmed":"11462792","source":"CTD"},{"chemical_name":"Reactive Oxygen Species","direct_evidence":"marker/mechanism","mesh_chemical_id":"D017382","pubmed":"11462792","source":"CTD"},{"chemical_name":"Resveratrol","direct_evidence":"therapeutic","mesh_chemical_id":"D000077185","pubmed":["24252177","24885036"],"source":"CTD"},{"cas_registry_number":"14899-08-2","chemical_name":"rhodamine B","direct_evidence":"marker/mechanism","mesh_chemical_id":"C029773","pubmed":"40752076","source":"CTD"},{"cas_registry_number":"1744-22-5","chemical_name":"Riluzole","direct_evidence":"therapeutic","mesh_chemical_id":"D019782","pubmed":["10025816","10190739","10828653","17714844","21375347","21867702","22821110","26399668","29937981","31029113"],"source":"CTD"},{"chemical_name":"Rosuvastatin Calcium","direct_evidence":"marker/mechanism","mesh_chemical_id":"D000068718","pubmed":"29427042","source":"CTD"},{"chemical_name":"Selenic Acid","direct_evidence":"marker/mechanism","mesh_chemical_id":"D064586","pubmed":"21134276","source":"CTD"},{"cas_registry_number":"7783-00-8","chemical_name":"Selenious Acid","direct_evidence":"marker/mechanism","mesh_chemical_id":"D020887","pubmed":"23732511","source":"CTD"},{"cas_registry_number":"7782-49-2","chemical_name":"Selenium","direct_evidence":"marker/mechanism","mesh_chemical_id":"D012643","pubmed":["19891121","23732511","28337565","31629180"],"source":"CTD"},{"cas_registry_number":"7782-49-2","chemical_name":"Selenium","direct_evidence":"therapeutic","mesh_chemical_id":"D012643","pubmed":"28641283","source":"CTD"},{"cas_registry_number":"79902-63-9","chemical_name":"Simvastatin","direct_evidence":"marker/mechanism","mesh_chemical_id":"D019821","pubmed":"29427042","source":"CTD"},{"chemical_name":"Solvents","direct_evidence":"marker/mechanism","mesh_chemical_id":"D012997","pubmed":["25544309","27377857","28122372","32193761"],"source":"CTD"},{"cas_registry_number":"50-35-1","chemical_name":"Thalidomide","direct_evidence":"therapeutic","mesh_chemical_id":"D013792","pubmed":["16510725","18425621"],"source":"CTD"},{"cas_registry_number":"62-46-4","chemical_name":"Thioctic Acid","direct_evidence":"therapeutic","mesh_chemical_id":"D008063","pubmed":"28641283","source":"CTD"},{"chemical_name":"Tobacco Smoke Pollution","direct_evidence":"marker/mechanism","mesh_chemical_id":"D014028","pubmed":"27377857","source":"CTD"},{"cas_registry_number":"99-20-7","chemical_name":"Trehalose","direct_evidence":"therapeutic","mesh_chemical_id":"D014199","pubmed":"23851366","source":"CTD"},{"chemical_name":"Triglycerides","direct_evidence":"marker/mechanism","mesh_chemical_id":"D014280","pubmed":"24919836","source":"CTD"},{"cas_registry_number":"4076-02-2","chemical_name":"Unithiol","direct_evidence":"therapeutic","mesh_chemical_id":"D014494","pubmed":"28641283","source":"CTD"},{"chemical_name":"Vehicle Emissions","direct_evidence":"marker/mechanism","mesh_chemical_id":"D001335","pubmed":"29852480","source":"CTD"},{"cas_registry_number":"75-01-4","chemical_name":"Vinyl Chloride","direct_evidence":"marker/mechanism","mesh_chemical_id":"D014752","pubmed":"24552493","source":"CTD"},{"cas_registry_number":"1406-18-4","chemical_name":"Vitamin E","direct_evidence":"marker/mechanism","mesh_chemical_id":"D014810","pubmed":"24919836","source":"CTD"},{"chemical_name":"Water Pollutants, Chemical","direct_evidence":"marker/mechanism","mesh_chemical_id":"D014874","pubmed":"33562464","source":"CTD"}],"mesh":"D000690","pathway_related_to_disease":[{"inference_gene_symbol":["GSR","GSTP1"],"kegg_pathway_id":"hsa00480","pathway_name":"Glutathione metabolism","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa00564","pathway_name":"Glycerophospholipid metabolism","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa00565","pathway_name":"Ether lipid metabolism","source":"CTD"},{"inference_gene_symbol":["PLA2G4A","PTGS2"],"kegg_pathway_id":"hsa00590","pathway_name":"Arachidonic acid metabolism","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa00591","pathway_name":"Linoleic acid metabolism","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa00592","pathway_name":"alpha-Linolenic acid metabolism","source":"CTD"},{"inference_gene_symbol":"GSTP1","kegg_pathway_id":"hsa00980","pathway_name":"Metabolism of xenobiotics by cytochrome P450","source":"CTD"},{"inference_gene_symbol":"GSTP1","kegg_pathway_id":"hsa00982","pathway_name":"Drug metabolism - cytochrome P450","source":"CTD"},{"inference_gene_symbol":["PLA2G4A","PON1","PTGS2"],"kegg_pathway_id":"hsa01100","pathway_name":"Metabolic pathways","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa01522","pathway_name":"Endocrine resistance","source":"CTD"},{"inference_gene_symbol":["GSTP1","TP53"],"kegg_pathway_id":"hsa01524","pathway_name":"Platinum drug resistance","source":"CTD"},{"inference_gene_symbol":["PLA2G4A","TP53"],"kegg_pathway_id":"hsa04010","pathway_name":"MAPK signaling pathway","source":"CTD"},{"inference_gene_symbol":"ERBB4","kegg_pathway_id":"hsa04012","pathway_name":"ErbB signaling pathway","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa04014","pathway_name":"Ras signaling pathway","source":"CTD"},{"inference_gene_symbol":"ERBB4","kegg_pathway_id":"hsa04020","pathway_name":"Calcium signaling pathway","source":"CTD"},{"inference_gene_symbol":["CD40LG","TNFRSF21"],"kegg_pathway_id":"hsa04060","pathway_name":"Cytokine-cytokine receptor interaction","source":"CTD"},{"inference_gene_symbol":["CD40LG","PTGS2"],"kegg_pathway_id":"hsa04064","pathway_name":"NF-kappa B signaling pathway","source":"CTD"},{"inference_gene_symbol":"SOD2","kegg_pathway_id":"hsa04068","pathway_name":"FoxO signaling pathway","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa04071","pathway_name":"Sphingolipid signaling pathway","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa04072","pathway_name":"Phospholipase D signaling pathway","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa04110","pathway_name":"Cell cycle","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa04115","pathway_name":"p53 signaling pathway","source":"CTD"},{"inference_gene_symbol":["MFN1","MFN2","OPTN","SQSTM1","TP53","UBB"],"kegg_pathway_id":"hsa04137","pathway_name":"Mitophagy - animal","source":"CTD"},{"inference_gene_symbol":"NFE2L2","kegg_pathway_id":"hsa04141","pathway_name":"Protein processing in endoplasmic reticulum","source":"CTD"},{"inference_gene_symbol":["CHMP2B","ERBB4"],"kegg_pathway_id":"hsa04144","pathway_name":"Endocytosis","source":"CTD"},{"inference_gene_symbol":"TUBA4A","kegg_pathway_id":"hsa04145","pathway_name":"Phagosome","source":"CTD"},{"inference_gene_symbol":["SOD1","SOD2"],"kegg_pathway_id":"hsa04146","pathway_name":"Peroxisome","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa04151","pathway_name":"PI3K-Akt signaling pathway","source":"CTD"},{"inference_gene_symbol":"PPARGC1A","kegg_pathway_id":"hsa04152","pathway_name":"AMPK signaling pathway","source":"CTD"},{"inference_gene_symbol":["TP53","TUBA4A"],"kegg_pathway_id":"hsa04210","pathway_name":"Apoptosis","source":"CTD"},{"inference_gene_symbol":["PPARGC1A","SOD2","TP53"],"kegg_pathway_id":"hsa04211","pathway_name":"Longevity regulating pathway","source":"CTD"},{"inference_gene_symbol":["SOD1","SOD2"],"kegg_pathway_id":"hsa04213","pathway_name":"Longevity regulating pathway - multiple species","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa04216","pathway_name":"Ferroptosis","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa04270","pathway_name":"Vascular smooth muscle contraction","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa04310","pathway_name":"Wnt signaling pathway","source":"CTD"},{"inference_gene_symbol":["PLA2G4A","PTGS2"],"kegg_pathway_id":"hsa04370","pathway_name":"VEGF signaling pathway","source":"CTD"},{"inference_gene_symbol":["NRF1","PPARGC1A"],"kegg_pathway_id":"hsa04371","pathway_name":"Apelin signaling pathway","source":"CTD"},{"inference_gene_symbol":"SQSTM1","kegg_pathway_id":"hsa04380","pathway_name":"Osteoclast differentiation","source":"CTD"},{"inference_gene_symbol":"CD40LG","kegg_pathway_id":"hsa04514","pathway_name":"Cell adhesion molecules (CAMs)","source":"CTD"},{"inference_gene_symbol":"TUBA4A","kegg_pathway_id":"hsa04530","pathway_name":"Tight junction","source":"CTD"},{"inference_gene_symbol":"TUBA4A","kegg_pathway_id":"hsa04540","pathway_name":"Gap junction","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa04611","pathway_name":"Platelet activation","source":"CTD"},{"inference_gene_symbol":["MFN1","MFN2"],"kegg_pathway_id":"hsa04621","pathway_name":"NOD-like receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":"GFAP","kegg_pathway_id":"hsa04630","pathway_name":"Jak-STAT signaling pathway","source":"CTD"},{"inference_gene_symbol":"PTGS2","kegg_pathway_id":"hsa04657","pathway_name":"IL-17 signaling pathway","source":"CTD"},{"inference_gene_symbol":"CD40LG","kegg_pathway_id":"hsa04660","pathway_name":"T cell receptor signaling pathway","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa04664","pathway_name":"Fc epsilon RI signaling pathway","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa04666","pathway_name":"Fc gamma R-mediated phagocytosis","source":"CTD"},{"inference_gene_symbol":"PTGS2","kegg_pathway_id":"hsa04668","pathway_name":"TNF signaling pathway","source":"CTD"},{"inference_gene_symbol":"CD40LG","kegg_pathway_id":"hsa04672","pathway_name":"Intestinal immune network for IgA production","source":"CTD"},{"inference_gene_symbol":"UNC13A","kegg_pathway_id":"hsa04721","pathway_name":"Synaptic vesicle cycle","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa04722","pathway_name":"Neurotrophin signaling pathway","source":"CTD"},{"inference_gene_symbol":"PTGS2","kegg_pathway_id":"hsa04723","pathway_name":"Retrograde endocannabinoid signaling","source":"CTD"},{"inference_gene_symbol":["PLA2G4A","SLC1A2"],"kegg_pathway_id":"hsa04724","pathway_name":"Glutamatergic synapse","source":"CTD"},{"inference_gene_symbol":["PLA2G4A","PTGS2"],"kegg_pathway_id":"hsa04726","pathway_name":"Serotonergic synapse","source":"CTD"},{"inference_gene_symbol":"SLC6A1","kegg_pathway_id":"hsa04727","pathway_name":"GABAergic synapse","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa04730","pathway_name":"Long-term depression","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa04750","pathway_name":"Inflammatory mediator regulation of TRP channels","source":"CTD"},{"inference_gene_symbol":"PPARGC1A","kegg_pathway_id":"hsa04910","pathway_name":"Insulin signaling pathway","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa04912","pathway_name":"GnRH signaling pathway","source":"CTD"},{"inference_gene_symbol":["PLA2G4A","PTGS2"],"kegg_pathway_id":"hsa04913","pathway_name":"Ovarian steroidogenesis","source":"CTD"},{"inference_gene_symbol":"GSR","kegg_pathway_id":"hsa04918","pathway_name":"Thyroid hormone synthesis","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa04919","pathway_name":"Thyroid hormone signaling pathway","source":"CTD"},{"inference_gene_symbol":"PPARGC1A","kegg_pathway_id":"hsa04920","pathway_name":"Adipocytokine signaling pathway","source":"CTD"},{"inference_gene_symbol":["CAMK1G","PLA2G4A","PTGS2"],"kegg_pathway_id":"hsa04921","pathway_name":"Oxytocin signaling pathway","source":"CTD"},{"inference_gene_symbol":"PPARGC1A","kegg_pathway_id":"hsa04922","pathway_name":"Glucagon signaling pathway","source":"CTD"},{"inference_gene_symbol":"PTGS2","kegg_pathway_id":"hsa04923","pathway_name":"Regulation of lipolysis in adipocytes","source":"CTD"},{"inference_gene_symbol":"CAMK1G","kegg_pathway_id":"hsa04925","pathway_name":"Aldosterone synthesis and secretion","source":"CTD"},{"inference_gene_symbol":["PPARGC1A","PPARGC1B"],"kegg_pathway_id":"hsa04931","pathway_name":"Insulin resistance","source":"CTD"},{"inference_gene_symbol":"UBB","kegg_pathway_id":"hsa05012","pathway_name":"Parkinson's disease","source":"CTD"},{"inference_gene_symbol":["SLC1A2","SOD1","TP53"],"kegg_pathway_id":"hsa05014","pathway_name":"Amyotrophic lateral sclerosis (ALS)","source":"CTD"},{"inference_gene_symbol":["NRF1","PPARGC1A","SOD1","SOD2","TP53"],"kegg_pathway_id":"hsa05016","pathway_name":"Huntington's disease","source":"CTD"},{"inference_gene_symbol":"SOD1","kegg_pathway_id":"hsa05020","pathway_name":"Prion diseases","source":"CTD"},{"inference_gene_symbol":"TUBA4A","kegg_pathway_id":"hsa05130","pathway_name":"Pathogenic Escherichia coli infection","source":"CTD"},{"inference_gene_symbol":"PTGS2","kegg_pathway_id":"hsa05140","pathway_name":"Leishmaniasis","source":"CTD"},{"inference_gene_symbol":"CD40LG","kegg_pathway_id":"hsa05144","pathway_name":"Malaria","source":"CTD"},{"inference_gene_symbol":"CD40LG","kegg_pathway_id":"hsa05145","pathway_name":"Toxoplasmosis","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05160","pathway_name":"Hepatitis C","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05161","pathway_name":"Hepatitis B","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05162","pathway_name":"Measles","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05166","pathway_name":"HTLV-I infection","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05168","pathway_name":"Herpes simplex infection","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05169","pathway_name":"Epstein-Barr virus infection","source":"CTD"},{"inference_gene_symbol":["GSTP1","PTGS2","TP53"],"kegg_pathway_id":"hsa05200","pathway_name":"Pathways in cancer","source":"CTD"},{"inference_gene_symbol":["FUS","TP53"],"kegg_pathway_id":"hsa05202","pathway_name":"Transcriptional misregulation in cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05203","pathway_name":"Viral carcinogenesis","source":"CTD"},{"inference_gene_symbol":["GSTP1","PTGS2"],"kegg_pathway_id":"hsa05204","pathway_name":"Chemical carcinogenesis","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53"],"kegg_pathway_id":"hsa05205","pathway_name":"Proteoglycans in cancer","source":"CTD"},{"inference_gene_symbol":["MIR206","MIR214","MIR23A","PTGS2","TP53"],"kegg_pathway_id":"hsa05206","pathway_name":"MicroRNAs in cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05210","pathway_name":"Colorectal cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05212","pathway_name":"Pancreatic cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05213","pathway_name":"Endometrial cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05214","pathway_name":"Glioma","source":"CTD"},{"inference_gene_symbol":["GSTP1","TP53"],"kegg_pathway_id":"hsa05215","pathway_name":"Prostate cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05216","pathway_name":"Thyroid cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05217","pathway_name":"Basal cell carcinoma","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05218","pathway_name":"Melanoma","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05219","pathway_name":"Bladder cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05220","pathway_name":"Chronic myeloid leukemia","source":"CTD"},{"inference_gene_symbol":["PTGS2","TP53"],"kegg_pathway_id":"hsa05222","pathway_name":"Small cell lung cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05223","pathway_name":"Non-small cell lung cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05224","pathway_name":"Breast cancer","source":"CTD"},{"inference_gene_symbol":"TP53","kegg_pathway_id":"hsa05230","pathway_name":"Central carbon metabolism in cancer","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","kegg_pathway_id":"hsa05231","pathway_name":"Choline metabolism in cancer","source":"CTD"},{"inference_gene_symbol":"CD40LG","kegg_pathway_id":"hsa05310","pathway_name":"Asthma","source":"CTD"},{"inference_gene_symbol":"CD40LG","kegg_pathway_id":"hsa05320","pathway_name":"Autoimmune thyroid disease","source":"CTD"},{"inference_gene_symbol":"CD40LG","kegg_pathway_id":"hsa05322","pathway_name":"Systemic lupus erythematosus","source":"CTD"},{"inference_gene_symbol":"CD40LG","kegg_pathway_id":"hsa05330","pathway_name":"Allograft rejection","source":"CTD"},{"inference_gene_symbol":"CD40LG","kegg_pathway_id":"hsa05340","pathway_name":"Primary immunodeficiency","source":"CTD"},{"inference_gene_symbol":"CD40LG","kegg_pathway_id":"hsa05416","pathway_name":"Viral myocarditis","source":"CTD"},{"inference_gene_symbol":["GSTP1","NFE2L2","SQSTM1","TP53"],"kegg_pathway_id":"hsa05418","pathway_name":"Fluid shear stress and atherosclerosis","source":"CTD"},{"inference_gene_symbol":"CHMP2B","kegg_pathway_id":"hsa_M00412","pathway_name":"ESCRT-III complex","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Apoptosis","react_pathway_id":"R-HSA-109581","source":"CTD"},{"inference_gene_symbol":["MFN1","MFN2","PLA2G4A","SOD1","TP53","TUBA4A"],"pathway_name":"Hemostasis","react_pathway_id":"R-HSA-109582","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Intrinsic Pathway for Apoptosis","react_pathway_id":"R-HSA-109606","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Translesion synthesis by REV1","react_pathway_id":"R-HSA-110312","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template","react_pathway_id":"R-HSA-110313","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Recognition of DNA damage by PCNA-containing replication complex","react_pathway_id":"R-HSA-110314","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Translesion Synthesis by POLH","react_pathway_id":"R-HSA-110320","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Activation of NOXA and translocation to mitochondria","react_pathway_id":"R-HSA-111448","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Opioid Signalling","react_pathway_id":"R-HSA-111885","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"phospho-PLA2 pathway","react_pathway_id":"R-HSA-111995","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Ca-dependent events","react_pathway_id":"R-HSA-111996","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"G-protein mediated events","react_pathway_id":"R-HSA-112040","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"PLC beta mediated events","react_pathway_id":"R-HSA-112043","source":"CTD"},{"inference_gene_symbol":["SLC1A2","SLC6A1"],"pathway_name":"Neurotransmitter Release Cycle","react_pathway_id":"R-HSA-112310","source":"CTD"},{"inference_gene_symbol":"SLC1A2","pathway_name":"Neurotransmitter uptake and Metabolism In Glial Cells","react_pathway_id":"R-HSA-112313","source":"CTD"},{"inference_gene_symbol":["SLC1A2","SLC6A1"],"pathway_name":"Transmission across Chemical Synapses","react_pathway_id":"R-HSA-112315","source":"CTD"},{"inference_gene_symbol":["SLC1A2","SLC6A1"],"pathway_name":"Neuronal System","react_pathway_id":"R-HSA-112316","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"IRS-mediated signalling","react_pathway_id":"R-HSA-112399","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"SOS-mediated signalling","react_pathway_id":"R-HSA-112412","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Activation of BH3-only proteins","react_pathway_id":"R-HSA-114452","source":"CTD"},{"inference_gene_symbol":["SOD1","TUBA4A"],"pathway_name":"Platelet degranulation","react_pathway_id":"R-HSA-114608","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53","UBB"],"pathway_name":"Downstream signaling events of B Cell Receptor (BCR)","react_pathway_id":"R-HSA-1168372","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Activation of NF-kappaB in B cells","react_pathway_id":"R-HSA-1169091","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"ISG15 antiviral mechanism","react_pathway_id":"R-HSA-1169408","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Antiviral mechanism by IFN-stimulated genes","react_pathway_id":"R-HSA-1169410","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Signaling by ERBB2","react_pathway_id":"R-HSA-1227986","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Regulation of Hypoxia-inducible Factor (HIF) by oxygen","react_pathway_id":"R-HSA-1234174","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","react_pathway_id":"R-HSA-1234176","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants","react_pathway_id":"R-HSA-1236382","source":"CTD"},{"inference_gene_symbol":["ERBB4","GFAP","UBB"],"pathway_name":"Signaling by ERBB4","react_pathway_id":"R-HSA-1236394","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"ER-Phagosome pathway","react_pathway_id":"R-HSA-1236974","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Antigen processing-Cross presentation","react_pathway_id":"R-HSA-1236975","source":"CTD"},{"inference_gene_symbol":"ERBB4","pathway_name":"SHC1 events in ERBB2 signaling","react_pathway_id":"R-HSA-1250196","source":"CTD"},{"inference_gene_symbol":"ERBB4","pathway_name":"PI3K events in ERBB4 signaling","react_pathway_id":"R-HSA-1250342","source":"CTD"},{"inference_gene_symbol":"ERBB4","pathway_name":"SHC1 events in ERBB4 signaling","react_pathway_id":"R-HSA-1250347","source":"CTD"},{"inference_gene_symbol":["ERBB4","GFAP"],"pathway_name":"Nuclear signaling by ERBB4","react_pathway_id":"R-HSA-1251985","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Downregulation of ERBB4 signaling","react_pathway_id":"R-HSA-1253288","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53"],"pathway_name":"PIP3 activates AKT signaling","react_pathway_id":"R-HSA-1257604","source":"CTD"},{"inference_gene_symbol":"SMARCA4","pathway_name":"Interleukin-7 signaling","react_pathway_id":"R-HSA-1266695","source":"CTD"},{"inference_gene_symbol":["ERBB4","PPARGC1A","UBB"],"pathway_name":"Developmental Biology","react_pathway_id":"R-HSA-1266738","source":"CTD"},{"inference_gene_symbol":["CD40LG","ERBB4","PTGS2","SMARCA4","SQSTM1","TP53","UBB"],"pathway_name":"Cytokine Signaling in Immune system","react_pathway_id":"R-HSA-1280215","source":"CTD"},{"inference_gene_symbol":["CD40LG","ERBB4","TP53","UBB"],"pathway_name":"Adaptive Immune System","react_pathway_id":"R-HSA-1280218","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Spry regulation of FGF signaling","react_pathway_id":"R-HSA-1295596","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Downregulation of ERBB2:ERBB3 signaling","react_pathway_id":"R-HSA-1358803","source":"CTD"},{"inference_gene_symbol":"PPARGC1A","pathway_name":"RORA activates gene expression","react_pathway_id":"R-HSA-1368082","source":"CTD"},{"inference_gene_symbol":"PPARGC1A","pathway_name":"BMAL1:CLOCK,NPAS2 activates circadian gene expression","react_pathway_id":"R-HSA-1368108","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Activation of PUMA and translocation to mitochondria","react_pathway_id":"R-HSA-139915","source":"CTD"},{"inference_gene_symbol":["ESRRA","GSR","GSTP1","NRF1","PLA2G4A","PON1","PPARGC1A","PPARGC1B","PTGS2","TNFRSF21","UBB"],"pathway_name":"Metabolism","react_pathway_id":"R-HSA-1430728","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53","UBB"],"pathway_name":"Signaling by SCF-KIT","react_pathway_id":"R-HSA-1433557","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Acyl chain remodelling of PC","react_pathway_id":"R-HSA-1482788","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Acyl chain remodeling of CL","react_pathway_id":"R-HSA-1482798","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Acyl chain remodelling of PS","react_pathway_id":"R-HSA-1482801","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Acyl chain remodelling of PE","react_pathway_id":"R-HSA-1482839","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Acyl chain remodelling of PI","react_pathway_id":"R-HSA-1482922","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Acyl chain remodelling of PG","react_pathway_id":"R-HSA-1482925","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Hydrolysis of LPC","react_pathway_id":"R-HSA-1483115","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Synthesis of PA","react_pathway_id":"R-HSA-1483166","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Glycerophospholipid biosynthesis","react_pathway_id":"R-HSA-1483206","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Phospholipid metabolism","react_pathway_id":"R-HSA-1483257","source":"CTD"},{"inference_gene_symbol":"GSTP1","pathway_name":"Phase II conjugation","react_pathway_id":"R-HSA-156580","source":"CTD"},{"inference_gene_symbol":"GSTP1","pathway_name":"Glutathione conjugation","react_pathway_id":"R-HSA-156590","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Signaling by NOTCH","react_pathway_id":"R-HSA-157118","source":"CTD"},{"inference_gene_symbol":"GSR","pathway_name":"Metabolism of nucleotides","react_pathway_id":"R-HSA-15869","source":"CTD"},{"inference_gene_symbol":["ESRRA","NRF1","PPARGC1A","PPARGC1B"],"pathway_name":"Mitochondrial biogenesis","react_pathway_id":"R-HSA-1592230","source":"CTD"},{"inference_gene_symbol":["ERBB4","GFAP","PLA2G4A","SMARCA4","SQSTM1","TP53","UBB"],"pathway_name":"Signal Transduction","react_pathway_id":"R-HSA-162582","source":"CTD"},{"inference_gene_symbol":["CHMP2B","UBB"],"pathway_name":"HIV Life Cycle","react_pathway_id":"R-HSA-162587","source":"CTD"},{"inference_gene_symbol":["CHMP2B","UBB"],"pathway_name":"Budding and maturation of HIV virion","react_pathway_id":"R-HSA-162588","source":"CTD"},{"inference_gene_symbol":["CHMP2B","UBB"],"pathway_name":"Late Phase of HIV Life Cycle","react_pathway_id":"R-HSA-162599","source":"CTD"},{"inference_gene_symbol":["CHMP2B","UBB"],"pathway_name":"HIV Infection","react_pathway_id":"R-HSA-162906","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Host Interactions of HIV factors","react_pathway_id":"R-HSA-162909","source":"CTD"},{"inference_gene_symbol":"CHMP2B","pathway_name":"Macroautophagy","react_pathway_id":"R-HSA-1632852","source":"CTD"},{"inference_gene_symbol":["OPTN","TP53","TUBA4A","UBB"],"pathway_name":"Cell Cycle","react_pathway_id":"R-HSA-1640170","source":"CTD"},{"inference_gene_symbol":["CHMP2B","ERBB4","SOD2","UBB"],"pathway_name":"Disease","react_pathway_id":"R-HSA-1643685","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by EGFR in Cancer","react_pathway_id":"R-HSA-1643713","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Toll Like Receptor 4 (TLR4) Cascade","react_pathway_id":"R-HSA-166016","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Activated TLR4 signalling","react_pathway_id":"R-HSA-166054","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"MyD88:Mal cascade initiated on plasma membrane","react_pathway_id":"R-HSA-166058","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"MyD88-independent TLR3/TLR4 cascade","react_pathway_id":"R-HSA-166166","source":"CTD"},{"inference_gene_symbol":["ERBB4","SQSTM1","TP53","UBB"],"pathway_name":"Signalling by NGF","react_pathway_id":"R-HSA-166520","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Signalling to RAS","react_pathway_id":"R-HSA-167044","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Toll Like Receptor 9 (TLR9) Cascade","react_pathway_id":"R-HSA-168138","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Toll Like Receptor 10 (TLR10) Cascade","react_pathway_id":"R-HSA-168142","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Toll Like Receptor 3 (TLR3) Cascade","react_pathway_id":"R-HSA-168164","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Toll Like Receptor 5 (TLR5) Cascade","react_pathway_id":"R-HSA-168176","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Toll Like Receptor TLR1:TLR2 Cascade","react_pathway_id":"R-HSA-168179","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Toll Like Receptor 7/8 (TLR7/8) Cascade","react_pathway_id":"R-HSA-168181","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Toll Like Receptor TLR6:TLR2 Cascade","react_pathway_id":"R-HSA-168188","source":"CTD"},{"inference_gene_symbol":["ERBB4","GSTP1","TP53","UBB"],"pathway_name":"Innate Immune System","react_pathway_id":"R-HSA-168249","source":"CTD"},{"inference_gene_symbol":["CD40LG","ERBB4","GSTP1","PTGS2","SMARCA4","SQSTM1","TP53","UBB"],"pathway_name":"Immune System","react_pathway_id":"R-HSA-168256","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Toll-Like Receptors Cascades","react_pathway_id":"R-HSA-168898","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways","react_pathway_id":"R-HSA-168928","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Prolonged ERK activation events","react_pathway_id":"R-HSA-169893","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Regulation of Apoptosis","react_pathway_id":"R-HSA-169911","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by TGF-beta Receptor Complex","react_pathway_id":"R-HSA-170834","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Frs2-mediated activation","react_pathway_id":"R-HSA-170968","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"ARMS-mediated activation","react_pathway_id":"R-HSA-170984","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"APC/C:Cdc20 mediated degradation of Cyclin B","react_pathway_id":"R-HSA-174048","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Autodegradation of Cdh1 by Cdh1:APC/C","react_pathway_id":"R-HSA-174084","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"SCF-beta-TrCP mediated degradation of Emi1","react_pathway_id":"R-HSA-174113","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"APC/C-mediated degradation of cell cycle proteins","react_pathway_id":"R-HSA-174143","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"APC/C:Cdc20 mediated degradation of Securin","react_pathway_id":"R-HSA-174154","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1","react_pathway_id":"R-HSA-174178","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Cdc20:Phospho-APC/C mediated degradation of Cyclin A","react_pathway_id":"R-HSA-174184","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Membrane binding and targetting of GAG proteins","react_pathway_id":"R-HSA-174490","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Synthesis And Processing Of GAG, GAGPOL Polyproteins","react_pathway_id":"R-HSA-174495","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Assembly Of The HIV Virion","react_pathway_id":"R-HSA-175474","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Regulation of APC/C activators between G1/S and early anaphase","react_pathway_id":"R-HSA-176408","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"APC/C:Cdc20 mediated degradation of mitotic proteins","react_pathway_id":"R-HSA-176409","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins","react_pathway_id":"R-HSA-176814","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53","UBB"],"pathway_name":"Signaling by EGFR","react_pathway_id":"R-HSA-177929","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"APC-Cdc20 mediated degradation of Nek2A","react_pathway_id":"R-HSA-179409","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint","react_pathway_id":"R-HSA-179419","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"GRB2 events in EGFR signaling","react_pathway_id":"R-HSA-179812","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53"],"pathway_name":"GAB1 signalosome","react_pathway_id":"R-HSA-180292","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"SHC1 events in EGFR signaling","react_pathway_id":"R-HSA-180336","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Vpu mediated degradation of CD4","react_pathway_id":"R-HSA-180534","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Vif-mediated degradation of APOBEC3G","react_pathway_id":"R-HSA-180585","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Toll Like Receptor 2 (TLR2) Cascade","react_pathway_id":"R-HSA-181438","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"EGFR downregulation","react_pathway_id":"R-HSA-182971","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Cytosolic sensors of pathogen-associated DNA","react_pathway_id":"R-HSA-1834949","source":"CTD"},{"inference_gene_symbol":["ESRRA","NRF1","PPARGC1A","PPARGC1B","TUBA4A"],"pathway_name":"Organelle biogenesis and maintenance","react_pathway_id":"R-HSA-1852241","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53","UBB"],"pathway_name":"Downstream signal transduction","react_pathway_id":"R-HSA-186763","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53","UBB"],"pathway_name":"Signaling by PDGF","react_pathway_id":"R-HSA-186797","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53","UBB"],"pathway_name":"NGF signalling via TRKA from the plasma membrane","react_pathway_id":"R-HSA-187037","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"SCF(Skp2)-mediated degradation of p27/p21","react_pathway_id":"R-HSA-187577","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Signalling to ERKs","react_pathway_id":"R-HSA-187687","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Signalling to p38 via RIT and RIN","react_pathway_id":"R-HSA-187706","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by FGFR","react_pathway_id":"R-HSA-190236","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Pre-NOTCH Transcription and Translation","react_pathway_id":"R-HSA-1912408","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Pre-NOTCH Expression and Processing","react_pathway_id":"R-HSA-1912422","source":"CTD"},{"inference_gene_symbol":["SQSTM1","UBB"],"pathway_name":"p75NTR signals via NF-kB","react_pathway_id":"R-HSA-193639","source":"CTD"},{"inference_gene_symbol":["SQSTM1","UBB"],"pathway_name":"p75 NTR receptor-mediated signalling","react_pathway_id":"R-HSA-193704","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Signaling by VEGF","react_pathway_id":"R-HSA-194138","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Degradation of beta-catenin by the destruction complex","react_pathway_id":"R-HSA-195253","source":"CTD"},{"inference_gene_symbol":["SMARCA4","UBB"],"pathway_name":"Signaling by Wnt","react_pathway_id":"R-HSA-195721","source":"CTD"},{"inference_gene_symbol":"ERBB4","pathway_name":"GRB2 events in ERBB2 signaling","react_pathway_id":"R-HSA-1963640","source":"CTD"},{"inference_gene_symbol":"ERBB4","pathway_name":"PI3K events in ERBB2 signaling","react_pathway_id":"R-HSA-1963642","source":"CTD"},{"inference_gene_symbol":"PTGS2","pathway_name":"Nicotinate metabolism","react_pathway_id":"R-HSA-196807","source":"CTD"},{"inference_gene_symbol":"PTGS2","pathway_name":"Metabolism of water-soluble vitamins and cofactors","react_pathway_id":"R-HSA-196849","source":"CTD"},{"inference_gene_symbol":"PTGS2","pathway_name":"Metabolism of vitamins and cofactors","react_pathway_id":"R-HSA-196854","source":"CTD"},{"inference_gene_symbol":"PTGS2","pathway_name":"Nicotinamide salvaging","react_pathway_id":"R-HSA-197264","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by NOTCH1","react_pathway_id":"R-HSA-1980143","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by NOTCH2","react_pathway_id":"R-HSA-1980145","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53"],"pathway_name":"PI3K/AKT activation","react_pathway_id":"R-HSA-198203","source":"CTD"},{"inference_gene_symbol":"CD40LG","pathway_name":"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","react_pathway_id":"R-HSA-198933","source":"CTD"},{"inference_gene_symbol":["ESRRA","NRF1","PPARGC1A","PPARGC1B","TNFRSF21"],"pathway_name":"PPARA activates gene expression","react_pathway_id":"R-HSA-1989781","source":"CTD"},{"inference_gene_symbol":"ERBB4","pathway_name":"Negative regulation of the PI3K/AKT network","react_pathway_id":"R-HSA-199418","source":"CTD"},{"inference_gene_symbol":"SCFD1","pathway_name":"ER to Golgi Anterograde Transport","react_pathway_id":"R-HSA-199977","source":"CTD"},{"inference_gene_symbol":["CHMP2B","OPTN","PLA2G4A","SCFD1","UBB"],"pathway_name":"Membrane Trafficking","react_pathway_id":"R-HSA-199991","source":"CTD"},{"inference_gene_symbol":["SMARCA4","UBB"],"pathway_name":"TCF dependent signaling in response to WNT","react_pathway_id":"R-HSA-201681","source":"CTD"},{"inference_gene_symbol":"SMARCA4","pathway_name":"Formation of the beta-catenin:TCF transactivating complex","react_pathway_id":"R-HSA-201722","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"TCR signaling","react_pathway_id":"R-HSA-202403","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Downstream TCR signaling","react_pathway_id":"R-HSA-202424","source":"CTD"},{"inference_gene_symbol":"SCFD1","pathway_name":"COPII (Coat Protein 2) Mediated Vesicle Transport","react_pathway_id":"R-HSA-204005","source":"CTD"},{"inference_gene_symbol":["SQSTM1","UBB"],"pathway_name":"Cell death signalling via NRAGE, NRIF and NADE","react_pathway_id":"R-HSA-204998","source":"CTD"},{"inference_gene_symbol":["SQSTM1","UBB"],"pathway_name":"NRIF signals cell death from the nucleus","react_pathway_id":"R-HSA-205043","source":"CTD"},{"inference_gene_symbol":["SQSTM1","UBB"],"pathway_name":"p75NTR recruits signalling complexes","react_pathway_id":"R-HSA-209543","source":"CTD"},{"inference_gene_symbol":["SQSTM1","UBB"],"pathway_name":"NF-kB is activated and signals survival","react_pathway_id":"R-HSA-209560","source":"CTD"},{"inference_gene_symbol":"SLC1A2","pathway_name":"Astrocytic Glutamate-Glutamine Uptake And Metabolism","react_pathway_id":"R-HSA-210455","source":"CTD"},{"inference_gene_symbol":"SLC1A2","pathway_name":"Glutamate Neurotransmitter Release Cycle","react_pathway_id":"R-HSA-210500","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Regulation of activated PAK-2p34 by proteasome mediated degradation","react_pathway_id":"R-HSA-211733","source":"CTD"},{"inference_gene_symbol":"GSTP1","pathway_name":"Biological oxidations","react_pathway_id":"R-HSA-211859","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"NOTCH1 Intracellular Domain Regulates Transcription","react_pathway_id":"R-HSA-2122947","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Activated NOTCH1 Transmits Signal to the Nucleus","react_pathway_id":"R-HSA-2122948","source":"CTD"},{"inference_gene_symbol":["ESRRA","GSR","TP53","UBB"],"pathway_name":"Generic Transcription Pathway","react_pathway_id":"R-HSA-212436","source":"CTD"},{"inference_gene_symbol":"PON1","pathway_name":"Synthesis of 5-eicosatetraenoic acids","react_pathway_id":"R-HSA-2142688","source":"CTD"},{"inference_gene_symbol":["PLA2G4A","PON1","PTGS2"],"pathway_name":"Arachidonic acid metabolism","react_pathway_id":"R-HSA-2142753","source":"CTD"},{"inference_gene_symbol":"PTGS2","pathway_name":"Synthesis of 15-eicosatetraenoic acid derivatives","react_pathway_id":"R-HSA-2142770","source":"CTD"},{"inference_gene_symbol":["ESRRA","NRF1","PPARGC1A","PPARGC1B"],"pathway_name":"Transcriptional activation of mitochondrial biogenesis","react_pathway_id":"R-HSA-2151201","source":"CTD"},{"inference_gene_symbol":"PPARGC1A","pathway_name":"Activation of PPARGC1A (PGC-1alpha) by phosphorylation","react_pathway_id":"R-HSA-2151209","source":"CTD"},{"inference_gene_symbol":"PTGS2","pathway_name":"Synthesis of Prostaglandins (PG) and Thromboxanes (TX)","react_pathway_id":"R-HSA-2162123","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53","UBB"],"pathway_name":"DAP12 interactions","react_pathway_id":"R-HSA-2172127","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Downregulation of TGF-beta receptor signaling","react_pathway_id":"R-HSA-2173788","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"TGF-beta receptor signaling activates SMADs","react_pathway_id":"R-HSA-2173789","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","react_pathway_id":"R-HSA-2173791","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer","react_pathway_id":"R-HSA-2173793","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Downregulation of SMAD2/3:SMAD4 transcriptional activity","react_pathway_id":"R-HSA-2173795","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription","react_pathway_id":"R-HSA-2173796","source":"CTD"},{"inference_gene_symbol":"ERBB4","pathway_name":"PI3K/AKT Signaling in Cancer","react_pathway_id":"R-HSA-2219528","source":"CTD"},{"inference_gene_symbol":"ERBB4","pathway_name":"Constitutive Signaling by Aberrant PI3K in Cancer","react_pathway_id":"R-HSA-2219530","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Cellular response to hypoxia","react_pathway_id":"R-HSA-2262749","source":"CTD"},{"inference_gene_symbol":["CHMP2B","GSR","GSTP1","SOD1","SOD2","TP53","UBB"],"pathway_name":"Cellular responses to stress","react_pathway_id":"R-HSA-2262752","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)","react_pathway_id":"R-HSA-2404192","source":"CTD"},{"inference_gene_symbol":"GSR","pathway_name":"Selenoamino acid metabolism","react_pathway_id":"R-HSA-2408522","source":"CTD"},{"inference_gene_symbol":"GSR","pathway_name":"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se","react_pathway_id":"R-HSA-2408550","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53","UBB"],"pathway_name":"DAP12 signaling","react_pathway_id":"R-HSA-2424491","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"IGF1R signaling cascade","react_pathway_id":"R-HSA-2428924","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"IRS-related events triggered by IGF1R","react_pathway_id":"R-HSA-2428928","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53","UBB"],"pathway_name":"Fc epsilon receptor (FCERI) signaling","react_pathway_id":"R-HSA-2454202","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Separation of Sister Chromatids","react_pathway_id":"R-HSA-2467813","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Mitotic Metaphase and Anaphase","react_pathway_id":"R-HSA-2555396","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Oxidative Stress Induced Senescence","react_pathway_id":"R-HSA-2559580","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Senescence-Associated Secretory Phenotype (SASP)","react_pathway_id":"R-HSA-2559582","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Cellular Senescence","react_pathway_id":"R-HSA-2559583","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Formation of Senescence-Associated Heterochromatin Foci (SAHF)","react_pathway_id":"R-HSA-2559584","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Oncogene Induced Senescence","react_pathway_id":"R-HSA-2559585","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"DNA Damage/Telomere Stress Induced Senescence","react_pathway_id":"R-HSA-2559586","source":"CTD"},{"inference_gene_symbol":["OPTN","TUBA4A","UBB"],"pathway_name":"Regulation of PLK1 Activity at G2/M Transition","react_pathway_id":"R-HSA-2565942","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Signaling by Leptin","react_pathway_id":"R-HSA-2586552","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by NOTCH1 PEST Domain Mutants in Cancer","react_pathway_id":"R-HSA-2644602","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by NOTCH1 in Cancer","react_pathway_id":"R-HSA-2644603","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Constitutive Signaling by NOTCH1 PEST Domain Mutants","react_pathway_id":"R-HSA-2644606","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Stimuli-sensing channels","react_pathway_id":"R-HSA-2672351","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by NOTCH1 HD Domain Mutants in Cancer","react_pathway_id":"R-HSA-2691230","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Constitutive Signaling by NOTCH1 HD Domain Mutants","react_pathway_id":"R-HSA-2691232","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53"],"pathway_name":"Role of LAT2/NTAL/LAB on calcium mobilization","react_pathway_id":"R-HSA-2730905","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"FCERI mediated MAPK activation","react_pathway_id":"R-HSA-2871796","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"FCERI mediated NF-kB activation","react_pathway_id":"R-HSA-2871837","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer","react_pathway_id":"R-HSA-2894858","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","react_pathway_id":"R-HSA-2894862","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"NOTCH2 Activation and Transmission of Signal to the Nucleus","react_pathway_id":"R-HSA-2979096","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"SUMOylation","react_pathway_id":"R-HSA-2990846","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"SUMO E3 ligases SUMOylate target proteins","react_pathway_id":"R-HSA-3108232","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Regulation of innate immune responses to cytosolic DNA","react_pathway_id":"R-HSA-3134975","source":"CTD"},{"inference_gene_symbol":["ACTL6B","SMARCA4"],"pathway_name":"RMTs methylate histone arginines","react_pathway_id":"R-HSA-3214858","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Glycogen storage diseases","react_pathway_id":"R-HSA-3229121","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"SUMOylation of transcription factors","react_pathway_id":"R-HSA-3232118","source":"CTD"},{"inference_gene_symbol":["ACTL6B","SMARCA4"],"pathway_name":"Chromatin modifying enzymes","react_pathway_id":"R-HSA-3247509","source":"CTD"},{"inference_gene_symbol":["GSR","GSTP1","SOD1","SOD2"],"pathway_name":"Detoxification of Reactive Oxygen Species","react_pathway_id":"R-HSA-3299685","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Glycogen synthesis","react_pathway_id":"R-HSA-3322077","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Autodegradation of the E3 ubiquitin ligase COP1","react_pathway_id":"R-HSA-349425","source":"CTD"},{"inference_gene_symbol":["GSR","TP53","UBB"],"pathway_name":"Transcriptional Regulation by TP53","react_pathway_id":"R-HSA-3700989","source":"CTD"},{"inference_gene_symbol":["ERBB4","PLA2G4A","UBB"],"pathway_name":"Signaling by GPCR","react_pathway_id":"R-HSA-372790","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"NCAM signaling for neurite out-growth","react_pathway_id":"R-HSA-375165","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Deactivation of the beta-catenin transactivating complex","react_pathway_id":"R-HSA-3769402","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Myoclonic epilepsy of Lafora","react_pathway_id":"R-HSA-3785653","source":"CTD"},{"inference_gene_symbol":"TUBA4A","pathway_name":"Loss of Nlp from mitotic centrosomes","react_pathway_id":"R-HSA-380259","source":"CTD"},{"inference_gene_symbol":"TUBA4A","pathway_name":"Recruitment of mitotic centrosome proteins and complexes","react_pathway_id":"R-HSA-380270","source":"CTD"},{"inference_gene_symbol":"TUBA4A","pathway_name":"Loss of proteins required for interphase microtubule organization from the centrosome","react_pathway_id":"R-HSA-380284","source":"CTD"},{"inference_gene_symbol":"TUBA4A","pathway_name":"Centrosome maturation","react_pathway_id":"R-HSA-380287","source":"CTD"},{"inference_gene_symbol":"PPARGC1A","pathway_name":"Transcriptional regulation of white adipocyte differentiation","react_pathway_id":"R-HSA-381340","source":"CTD"},{"inference_gene_symbol":["SLC1A2","SLC6A1","UBB"],"pathway_name":"Transmembrane transport of small molecules","react_pathway_id":"R-HSA-382551","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"ABC-family proteins mediated transport","react_pathway_id":"R-HSA-382556","source":"CTD"},{"inference_gene_symbol":"ESRRA","pathway_name":"Nuclear Receptor transcription pathway","react_pathway_id":"R-HSA-383280","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Beta-catenin independent WNT signaling","react_pathway_id":"R-HSA-3858494","source":"CTD"},{"inference_gene_symbol":"TUBA4A","pathway_name":"Prefoldin mediated transfer of substrate  to CCT/TriC","react_pathway_id":"R-HSA-389957","source":"CTD"},{"inference_gene_symbol":"TUBA4A","pathway_name":"Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding","react_pathway_id":"R-HSA-389958","source":"CTD"},{"inference_gene_symbol":"TUBA4A","pathway_name":"Formation of tubulin folding intermediates by CCT/TriC","react_pathway_id":"R-HSA-389960","source":"CTD"},{"inference_gene_symbol":"TUBA4A","pathway_name":"Post-chaperonin tubulin folding pathway","react_pathway_id":"R-HSA-389977","source":"CTD"},{"inference_gene_symbol":["TP53","TUBA4A"],"pathway_name":"Chaperonin-mediated protein folding","react_pathway_id":"R-HSA-390466","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Association of TriC/CCT with target proteins during biosynthesis","react_pathway_id":"R-HSA-390471","source":"CTD"},{"inference_gene_symbol":["TP53","TUBA4A"],"pathway_name":"Protein folding","react_pathway_id":"R-HSA-391251","source":"CTD"},{"inference_gene_symbol":["SCFD1","TP53","TUBA4A","UBB"],"pathway_name":"Metabolism of proteins","react_pathway_id":"R-HSA-392499","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Signal amplification","react_pathway_id":"R-HSA-392518","source":"CTD"},{"inference_gene_symbol":["ESRRA","NRF1","PPARGC1A","PPARGC1B","TNFRSF21"],"pathway_name":"Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)","react_pathway_id":"R-HSA-400206","source":"CTD"},{"inference_gene_symbol":["PPARGC1A","UBB"],"pathway_name":"Circadian Clock","react_pathway_id":"R-HSA-400253","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"PCP/CE pathway","react_pathway_id":"R-HSA-4086400","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Platelet homeostasis","react_pathway_id":"R-HSA-418346","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"ADP signalling through P2Y purinoceptor 1","react_pathway_id":"R-HSA-418592","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Axon guidance","react_pathway_id":"R-HSA-422475","source":"CTD"},{"inference_gene_symbol":"SLC6A1","pathway_name":"Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds","react_pathway_id":"R-HSA-425366","source":"CTD"},{"inference_gene_symbol":"SLC1A2","pathway_name":"Transport of inorganic cations/anions and amino acids/oligopeptides","react_pathway_id":"R-HSA-425393","source":"CTD"},{"inference_gene_symbol":["SLC1A2","SLC6A1"],"pathway_name":"SLC-mediated transmembrane transport","react_pathway_id":"R-HSA-425407","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Platelet sensitization by LDL","react_pathway_id":"R-HSA-432142","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"VEGFA-VEGFR2 Pathway","react_pathway_id":"R-HSA-4420097","source":"CTD"},{"inference_gene_symbol":"SLC6A1","pathway_name":"Na+/Cl- dependent neurotransmitter transporters","react_pathway_id":"R-HSA-442660","source":"CTD"},{"inference_gene_symbol":["SCFD1","UBB"],"pathway_name":"Asparagine N-linked glycosylation","react_pathway_id":"R-HSA-446203","source":"CTD"},{"inference_gene_symbol":["SQSTM1","UBB"],"pathway_name":"Interleukin-1 signaling","react_pathway_id":"R-HSA-446652","source":"CTD"},{"inference_gene_symbol":["ERBB4","PTGS2","SMARCA4","SQSTM1","TP53","UBB"],"pathway_name":"Signaling by Interleukins","react_pathway_id":"R-HSA-449147","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"MAP kinase activation in TLR cascade","react_pathway_id":"R-HSA-450294","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"AUF1 (hnRNP D0) binds and destabilizes mRNA","react_pathway_id":"R-HSA-450408","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Regulation of mRNA stability by proteins that bind AU-rich elements","react_pathway_id":"R-HSA-450531","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Interleukin-2 signaling","react_pathway_id":"R-HSA-451927","source":"CTD"},{"inference_gene_symbol":["OPTN","TP53","TUBA4A","UBB"],"pathway_name":"Mitotic G2-G2/M phases","react_pathway_id":"R-HSA-453274","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Regulation of mitotic cell cycle","react_pathway_id":"R-HSA-453276","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Mitotic G1-G1/S phases","react_pathway_id":"R-HSA-453279","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Asymmetric localization of PCP proteins","react_pathway_id":"R-HSA-4608870","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Degradation of AXIN","react_pathway_id":"R-HSA-4641257","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Degradation of DVL","react_pathway_id":"R-HSA-4641258","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Regulation of FZD by ubiquitination","react_pathway_id":"R-HSA-4641263","source":"CTD"},{"inference_gene_symbol":["ACTL6B","SMARCA4"],"pathway_name":"Chromatin organization","react_pathway_id":"R-HSA-4839726","source":"CTD"},{"inference_gene_symbol":"GSR","pathway_name":"Synthesis and interconversion of nucleotide di- and triphosphates","react_pathway_id":"R-HSA-499943","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Interleukin-3, 5 and GM-CSF signaling","react_pathway_id":"R-HSA-512988","source":"CTD"},{"inference_gene_symbol":["MFN1","MFN2","SQSTM1","UBB"],"pathway_name":"Mitophagy","react_pathway_id":"R-HSA-5205647","source":"CTD"},{"inference_gene_symbol":["MFN1","MFN2","SQSTM1","UBB"],"pathway_name":"Pink/Parkin Mediated Mitophagy","react_pathway_id":"R-HSA-5205685","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"VEGFR2 mediated cell proliferation","react_pathway_id":"R-HSA-5218921","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"N-glycan trimming in the ER and Calnexin/Calreticulin cycle","react_pathway_id":"R-HSA-532668","source":"CTD"},{"inference_gene_symbol":["ESRRA","NRF1","PPARGC1A","PPARGC1B","TNFRSF21"],"pathway_name":"Fatty acid, triacylglycerol, and ketone body metabolism","react_pathway_id":"R-HSA-535734","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Programmed Cell Death","react_pathway_id":"R-HSA-5357801","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Regulation of TNFR1 signaling","react_pathway_id":"R-HSA-5357905","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Hedgehog ligand biogenesis","react_pathway_id":"R-HSA-5358346","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by Hedgehog","react_pathway_id":"R-HSA-5358351","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD","react_pathway_id":"R-HSA-5362768","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Hh mutants abrogate ligand secretion","react_pathway_id":"R-HSA-5387390","source":"CTD"},{"inference_gene_symbol":["ESRRA","NRF1","PLA2G4A","PON1","PPARGC1A","PPARGC1B","PTGS2","TNFRSF21"],"pathway_name":"Metabolism of lipids and lipoproteins","react_pathway_id":"R-HSA-556833","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Dectin-1 mediated noncanonical NF-kB signaling","react_pathway_id":"R-HSA-5607761","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"CLEC7A (Dectin-1) signaling","react_pathway_id":"R-HSA-5607764","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Degradation of GLI1 by the proteasome","react_pathway_id":"R-HSA-5610780","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Degradation of GLI2 by the proteasome","react_pathway_id":"R-HSA-5610783","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"GLI3 is processed to GLI3R by the proteasome","react_pathway_id":"R-HSA-5610785","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Hedgehog 'off' state","react_pathway_id":"R-HSA-5610787","source":"CTD"},{"inference_gene_symbol":"TUBA4A","pathway_name":"Cilium Assembly","react_pathway_id":"R-HSA-5617833","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"ABC transporter disorders","react_pathway_id":"R-HSA-5619084","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Disorders of transmembrane transporters","react_pathway_id":"R-HSA-5619115","source":"CTD"},{"inference_gene_symbol":"TUBA4A","pathway_name":"Anchoring of the basal body to the plasma membrane","react_pathway_id":"R-HSA-5620912","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"C-type lectin receptors (CLRs)","react_pathway_id":"R-HSA-5621481","source":"CTD"},{"inference_gene_symbol":["GSR","TP53"],"pathway_name":"TP53 Regulates Metabolic Genes","react_pathway_id":"R-HSA-5628897","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Hedgehog 'on' state","react_pathway_id":"R-HSA-5632684","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Regulation of TP53 Activity","react_pathway_id":"R-HSA-5633007","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 Regulates Transcription of Cell Death Genes","react_pathway_id":"R-HSA-5633008","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by Ligand-Responsive EGFR Variants in Cancer","react_pathway_id":"R-HSA-5637815","source":"CTD"},{"inference_gene_symbol":["CHMP2B","OPTN","PLA2G4A","SCFD1","UBB"],"pathway_name":"Vesicle-mediated transport","react_pathway_id":"R-HSA-5653656","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Negative regulation of FGFR1 signaling","react_pathway_id":"R-HSA-5654726","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Negative regulation of FGFR2 signaling","react_pathway_id":"R-HSA-5654727","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Negative regulation of FGFR3 signaling","react_pathway_id":"R-HSA-5654732","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Negative regulation of FGFR4 signaling","react_pathway_id":"R-HSA-5654733","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by FGFR1","react_pathway_id":"R-HSA-5654736","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by FGFR2","react_pathway_id":"R-HSA-5654738","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by FGFR3","react_pathway_id":"R-HSA-5654741","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by FGFR4","react_pathway_id":"R-HSA-5654743","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Translesion synthesis by POLK","react_pathway_id":"R-HSA-5655862","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Translesion synthesis by POLI","react_pathway_id":"R-HSA-5656121","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Termination of translesion DNA synthesis","react_pathway_id":"R-HSA-5656169","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Regulation of RAS by GAPs","react_pathway_id":"R-HSA-5658442","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Diseases of carbohydrate metabolism","react_pathway_id":"R-HSA-5663084","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Diseases of signal transduction","react_pathway_id":"R-HSA-5663202","source":"CTD"},{"inference_gene_symbol":["CHMP2B","UBB"],"pathway_name":"Infectious disease","react_pathway_id":"R-HSA-5663205","source":"CTD"},{"inference_gene_symbol":["CD40LG","UBB"],"pathway_name":"TNFR2 non-canonical NF-kB pathway","react_pathway_id":"R-HSA-5668541","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Diseases of metabolism","react_pathway_id":"R-HSA-5668914","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"RAF/MAP kinase cascade","react_pathway_id":"R-HSA-5673001","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Negative regulation of MAPK pathway","react_pathway_id":"R-HSA-5675221","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"NIK-->noncanonical NF-kB signaling","react_pathway_id":"R-HSA-5676590","source":"CTD"},{"inference_gene_symbol":"CD40LG","pathway_name":"TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway","react_pathway_id":"R-HSA-5676594","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Defective CFTR causes cystic fibrosis","react_pathway_id":"R-HSA-5678895","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"MAPK family signaling cascades","react_pathway_id":"R-HSA-5683057","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"MAP3K8 (TPL2)-dependent MAPK1/3 activation","react_pathway_id":"R-HSA-5684264","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"MAPK1/MAPK3 signaling","react_pathway_id":"R-HSA-5684996","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"HDR through Homologous Recombination (HRR)","react_pathway_id":"R-HSA-5685942","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"MAPK6/MAPK4 signaling","react_pathway_id":"R-HSA-5687128","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Deubiquitination","react_pathway_id":"R-HSA-5688426","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"UCH proteinases","react_pathway_id":"R-HSA-5689603","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Josephin domain DUBs","react_pathway_id":"R-HSA-5689877","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Ub-specific processing proteases","react_pathway_id":"R-HSA-5689880","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Ovarian tumor domain proteases","react_pathway_id":"R-HSA-5689896","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Metalloprotease DUBs","react_pathway_id":"R-HSA-5689901","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"DNA Double-Strand Break Repair","react_pathway_id":"R-HSA-5693532","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Homology Directed Repair","react_pathway_id":"R-HSA-5693538","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks","react_pathway_id":"R-HSA-5693565","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)","react_pathway_id":"R-HSA-5693567","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"DNA Double Strand Break Response","react_pathway_id":"R-HSA-5693606","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Processing of DNA double-strand break ends","react_pathway_id":"R-HSA-5693607","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"DNA Damage Recognition in GG-NER","react_pathway_id":"R-HSA-5696394","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Formation of Incision Complex in GG-NER","react_pathway_id":"R-HSA-5696395","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Gap-filling DNA repair synthesis and ligation in GG-NER","react_pathway_id":"R-HSA-5696397","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Nucleotide Excision Repair","react_pathway_id":"R-HSA-5696398","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Global Genome Nucleotide Excision Repair (GG-NER)","react_pathway_id":"R-HSA-5696399","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Dual Incision in GG-NER","react_pathway_id":"R-HSA-5696400","source":"CTD"},{"inference_gene_symbol":["SCFD1","TP53","UBB"],"pathway_name":"Post-translational protein modification","react_pathway_id":"R-HSA-597592","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Formation of TC-NER Pre-Incision Complex","react_pathway_id":"R-HSA-6781823","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Transcription-Coupled Nucleotide Excision Repair (TC-NER)","react_pathway_id":"R-HSA-6781827","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Dual incision in TC-NER","react_pathway_id":"R-HSA-6782135","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Gap-filling DNA repair synthesis and ligation in TC-NER","react_pathway_id":"R-HSA-6782210","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Fanconi Anemia Pathway","react_pathway_id":"R-HSA-6783310","source":"CTD"},{"inference_gene_symbol":"PTGS2","pathway_name":"Interleukin-10 signaling","react_pathway_id":"R-HSA-6783783","source":"CTD"},{"inference_gene_symbol":"ERBB4","pathway_name":"ERBB2 Regulates Cell Motility","react_pathway_id":"R-HSA-6785631","source":"CTD"},{"inference_gene_symbol":["PTGS2","TP53"],"pathway_name":"Interleukin-4 and 13 signaling","react_pathway_id":"R-HSA-6785807","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 Regulates Transcription of Cell Cycle Genes","react_pathway_id":"R-HSA-6791312","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 Regulates Transcription of DNA Repair Genes","react_pathway_id":"R-HSA-6796648","source":"CTD"},{"inference_gene_symbol":"GSTP1","pathway_name":"Neutrophil degranulation","react_pathway_id":"R-HSA-6798695","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release","react_pathway_id":"R-HSA-6803204","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","react_pathway_id":"R-HSA-6803205","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 Regulates Transcription of Caspase Activators and Caspases","react_pathway_id":"R-HSA-6803207","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 Regulates Transcription of Death Receptors and Ligands","react_pathway_id":"R-HSA-6803211","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","react_pathway_id":"R-HSA-6804114","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","react_pathway_id":"R-HSA-6804115","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest","react_pathway_id":"R-HSA-6804116","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Regulation of TP53 Expression","react_pathway_id":"R-HSA-6804754","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Regulation of TP53 Activity through Phosphorylation","react_pathway_id":"R-HSA-6804756","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Regulation of TP53 Degradation","react_pathway_id":"R-HSA-6804757","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Regulation of TP53 Activity through Acetylation","react_pathway_id":"R-HSA-6804758","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Regulation of TP53 Activity through Association with Co-factors","react_pathway_id":"R-HSA-6804759","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Regulation of TP53 Activity through Methylation","react_pathway_id":"R-HSA-6804760","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Regulation of TP53 Expression and Degradation","react_pathway_id":"R-HSA-6806003","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Signaling by MET","react_pathway_id":"R-HSA-6806834","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Negative regulation of MET activity","react_pathway_id":"R-HSA-6807004","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"COPI-independent Golgi-to-ER retrograde traffic","react_pathway_id":"R-HSA-6811436","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Intra-Golgi and retrograde Golgi-to-ER traffic","react_pathway_id":"R-HSA-6811442","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"PI5P Regulates TP53 Acetylation","react_pathway_id":"R-HSA-6811555","source":"CTD"},{"inference_gene_symbol":"ERBB4","pathway_name":"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling","react_pathway_id":"R-HSA-6811558","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"CDT1 association with the CDC6:ORC:origin complex","react_pathway_id":"R-HSA-68827","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Assembly of the pre-replicative complex","react_pathway_id":"R-HSA-68867","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"M/G1 Transition","react_pathway_id":"R-HSA-68874","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Mitotic Anaphase","react_pathway_id":"R-HSA-68882","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"M Phase","react_pathway_id":"R-HSA-68886","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Orc1 removal from chromatin","react_pathway_id":"R-HSA-68949","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"DNA Replication Pre-Initiation","react_pathway_id":"R-HSA-69002","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"CDK-mediated phosphorylation and removal of Cdc6","react_pathway_id":"R-HSA-69017","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Switching of origins to a post-replicative state","react_pathway_id":"R-HSA-69052","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Cyclin E associated events during G1/S transition","react_pathway_id":"R-HSA-69202","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"G1/S Transition","react_pathway_id":"R-HSA-69206","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Ubiquitin-dependent degradation of Cyclin D1","react_pathway_id":"R-HSA-69229","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Cyclin D associated events in G1","react_pathway_id":"R-HSA-69231","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"G1 Phase","react_pathway_id":"R-HSA-69236","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Synthesis of DNA","react_pathway_id":"R-HSA-69239","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"S Phase","react_pathway_id":"R-HSA-69242","source":"CTD"},{"inference_gene_symbol":["OPTN","TP53","TUBA4A","UBB"],"pathway_name":"G2/M Transition","react_pathway_id":"R-HSA-69275","source":"CTD"},{"inference_gene_symbol":["OPTN","TP53","TUBA4A","UBB"],"pathway_name":"Cell Cycle, Mitotic","react_pathway_id":"R-HSA-69278","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Association of licensing factors with the pre-replicative complex","react_pathway_id":"R-HSA-69298","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Removal of licensing factors from origins","react_pathway_id":"R-HSA-69300","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Regulation of DNA replication","react_pathway_id":"R-HSA-69304","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"DNA Replication","react_pathway_id":"R-HSA-69306","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"G2/M DNA damage checkpoint","react_pathway_id":"R-HSA-69473","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"G2/M Checkpoints","react_pathway_id":"R-HSA-69481","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Stabilization of p53","react_pathway_id":"R-HSA-69541","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Transcriptional activation of p53 responsive genes","react_pathway_id":"R-HSA-69560","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"p53-Dependent G1 DNA Damage Response","react_pathway_id":"R-HSA-69563","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"p53-Dependent G1/S DNA damage checkpoint","react_pathway_id":"R-HSA-69580","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A","react_pathway_id":"R-HSA-69601","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"p53-Independent DNA Damage Response","react_pathway_id":"R-HSA-69610","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"p53-Independent G1/S DNA damage checkpoint","react_pathway_id":"R-HSA-69613","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"G1/S DNA Damage Checkpoints","react_pathway_id":"R-HSA-69615","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"Cell Cycle Checkpoints","react_pathway_id":"R-HSA-69620","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Cyclin A:Cdk2-associated events at S phase entry","react_pathway_id":"R-HSA-69656","source":"CTD"},{"inference_gene_symbol":"TP53","pathway_name":"Transcriptional  activation of  cell cycle inhibitor p21","react_pathway_id":"R-HSA-69895","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Glucose metabolism","react_pathway_id":"R-HSA-70326","source":"CTD"},{"inference_gene_symbol":"GSR","pathway_name":"Metabolism of amino acids and derivatives","react_pathway_id":"R-HSA-71291","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Metabolism of carbohydrates","react_pathway_id":"R-HSA-71387","source":"CTD"},{"inference_gene_symbol":"FUS","pathway_name":"mRNA Splicing - Major Pathway","react_pathway_id":"R-HSA-72163","source":"CTD"},{"inference_gene_symbol":"FUS","pathway_name":"mRNA Splicing","react_pathway_id":"R-HSA-72172","source":"CTD"},{"inference_gene_symbol":"FUS","pathway_name":"Processing of Capped Intron-Containing Pre-mRNA","react_pathway_id":"R-HSA-72203","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Death Receptor Signalling","react_pathway_id":"R-HSA-73887","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"DNA Damage Bypass","react_pathway_id":"R-HSA-73893","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"DNA Repair","react_pathway_id":"R-HSA-73894","source":"CTD"},{"inference_gene_symbol":["ESRRA","FUS","GSR","TP53","UBB"],"pathway_name":"Gene Expression","react_pathway_id":"R-HSA-74160","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Insulin receptor signalling cascade","react_pathway_id":"R-HSA-74751","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Signaling by Insulin receptor","react_pathway_id":"R-HSA-74752","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Ubiquitin-dependent degradation of Cyclin D","react_pathway_id":"R-HSA-75815","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"TNF signaling","react_pathway_id":"R-HSA-75893","source":"CTD"},{"inference_gene_symbol":["PLA2G4A","SOD1","TUBA4A"],"pathway_name":"Platelet activation, signaling and aggregation","react_pathway_id":"R-HSA-76002","source":"CTD"},{"inference_gene_symbol":["SOD1","TUBA4A"],"pathway_name":"Response to elevated platelet cytosolic Ca2+","react_pathway_id":"R-HSA-76005","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Gastrin-CREB signalling pathway via PKC and MAPK","react_pathway_id":"R-HSA-881907","source":"CTD"},{"inference_gene_symbol":"ERBB4","pathway_name":"ERBB2 Activates PTK6 Signaling","react_pathway_id":"R-HSA-8847993","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Signaling by PTK6","react_pathway_id":"R-HSA-8848021","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1","react_pathway_id":"R-HSA-8849469","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Protein ubiquitination","react_pathway_id":"R-HSA-8852135","source":"CTD"},{"inference_gene_symbol":["TP53","UBB"],"pathway_name":"The role of GTSE1 in G2/M progression after G2 checkpoint","react_pathway_id":"R-HSA-8852276","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"RET signaling","react_pathway_id":"R-HSA-8853659","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis","react_pathway_id":"R-HSA-8854050","source":"CTD"},{"inference_gene_symbol":"OPTN","pathway_name":"TBC/RABGAPs","react_pathway_id":"R-HSA-8854214","source":"CTD"},{"inference_gene_symbol":"TUBA4A","pathway_name":"AURKA Activation by TPX2","react_pathway_id":"R-HSA-8854518","source":"CTD"},{"inference_gene_symbol":"PLA2G4A","pathway_name":"Golgi-to-ER retrograde transport","react_pathway_id":"R-HSA-8856688","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Cargo recognition for clathrin-mediated endocytosis","react_pathway_id":"R-HSA-8856825","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Clathrin-mediated endocytosis","react_pathway_id":"R-HSA-8856828","source":"CTD"},{"inference_gene_symbol":"SOD2","pathway_name":"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","react_pathway_id":"R-HSA-8862803","source":"CTD"},{"inference_gene_symbol":"SOD2","pathway_name":"Neurodegenerative Diseases","react_pathway_id":"R-HSA-8863678","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Downregulation of ERBB2 signaling","react_pathway_id":"R-HSA-8863795","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Synthesis of active ubiquitin: roles of E1 and E2 enzymes","react_pathway_id":"R-HSA-8866652","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"E3 ubiquitin ligases ubiquitinate target proteins","react_pathway_id":"R-HSA-8866654","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"InlB-mediated entry of Listeria monocytogenes into host cell","react_pathway_id":"R-HSA-8875360","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Listeria monocytogenes entry into host cells","react_pathway_id":"R-HSA-8876384","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"InlA-mediated entry of Listeria monocytogenes into host cells","react_pathway_id":"R-HSA-8876493","source":"CTD"},{"inference_gene_symbol":"SLC6A1","pathway_name":"GABA synthesis, release, reuptake and degradation","react_pathway_id":"R-HSA-888590","source":"CTD"},{"inference_gene_symbol":"SLC6A1","pathway_name":"Reuptake of GABA","react_pathway_id":"R-HSA-888593","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"ER Quality Control Compartment (ERQC)","react_pathway_id":"R-HSA-901032","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Calnexin/calreticulin cycle","react_pathway_id":"R-HSA-901042","source":"CTD"},{"inference_gene_symbol":["ERBB4","UBB"],"pathway_name":"Interleukin receptor SHC signaling","react_pathway_id":"R-HSA-912526","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Interferon Signaling","react_pathway_id":"R-HSA-913531","source":"CTD"},{"inference_gene_symbol":["CHMP2B","UBB"],"pathway_name":"Endosomal Sorting Complex Required For Transport (ESCRT)","react_pathway_id":"R-HSA-917729","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Negative regulators of RIG-I/MDA5 signaling","react_pathway_id":"R-HSA-936440","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon","react_pathway_id":"R-HSA-936964","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"IKK complex recruitment mediated by RIP1","react_pathway_id":"R-HSA-937041","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"IRAK2 mediated activation of TAK1 complex","react_pathway_id":"R-HSA-937042","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"TRIF-mediated TLR3/TLR4 signaling","react_pathway_id":"R-HSA-937061","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"TRAF6 mediated induction of TAK1 complex","react_pathway_id":"R-HSA-937072","source":"CTD"},{"inference_gene_symbol":"SCFD1","pathway_name":"Transport to the Golgi and subsequent modification","react_pathway_id":"R-HSA-948021","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation","react_pathway_id":"R-HSA-975138","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"MyD88 dependent cascade initiated on endosome","react_pathway_id":"R-HSA-975155","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation","react_pathway_id":"R-HSA-975163","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"MyD88 cascade initiated on plasma membrane","react_pathway_id":"R-HSA-975871","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Amyloid fiber formation","react_pathway_id":"R-HSA-977225","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Antigen processing: Ubiquitination & Proteasome degradation","react_pathway_id":"R-HSA-983168","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Class I MHC mediated antigen processing & presentation","react_pathway_id":"R-HSA-983169","source":"CTD"},{"inference_gene_symbol":["MFN1","MFN2","TP53"],"pathway_name":"Factors involved in megakaryocyte development and platelet production","react_pathway_id":"R-HSA-983231","source":"CTD"},{"inference_gene_symbol":["ERBB4","TP53","UBB"],"pathway_name":"Signaling by the B Cell Receptor (BCR)","react_pathway_id":"R-HSA-983705","source":"CTD"},{"inference_gene_symbol":"UBB","pathway_name":"Ion channel transport","react_pathway_id":"R-HSA-983712","source":"CTD"}]},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:331","DOID:4","DOID:1289","DOID:231","DOID:863","DOID:7"],"children":["DOID:0050752","DOID:0060193","DOID:0060194","DOID:0060195","DOID:0060196","DOID:0060197","DOID:0060198","DOID:0060199","DOID:0060200","DOID:0060201","DOID:0060202","DOID:0060203","DOID:0060204","DOID:0060205","DOID:0060206","DOID:0060207","DOID:0060209","DOID:0060210","DOID:0060211","DOID:0060212","DOID:0060213","DOID:0060214","DOID:0060355","DOID:0080225","DOID:0080917","DOID:0081378","DOID:0081379","DOID:0081380","DOID:0081381","DOID:0081382","DOID:0110067","DOID:0110068","DOID:0110069","DOID:0111227"],"def":"\"A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.\" [url:http\\://en.wikipedia.org/wiki/Amyotrophic_lateral_sclerosis, url:http\\://www.ninds.nih.gov/disorders/amyotrophiclateralsclerosis/detail_ALS.htm]","descendants":["DOID:0060198","DOID:0111227","DOID:0060194","DOID:0060199","DOID:0081382","DOID:0060205","DOID:0060196","DOID:0060210","DOID:0060201","DOID:0060211","DOID:0081380","DOID:0060200","DOID:0060202","DOID:0080917","DOID:0110067","DOID:0060207","DOID:0060209","DOID:0080225","DOID:0060213","DOID:0060197","DOID:0060195","DOID:0060214","DOID:0060204","DOID:0110069","DOID:0060203","DOID:0060193","DOID:0081381","DOID:0060355","DOID:0060212","DOID:0110068","DOID:0081378","DOID:0081379","DOID:0050752","DOID:0060206"],"doid":"DOID:332","name":"amyotrophic lateral sclerosis","parents":["DOID:231"],"synonyms":{"exact":["ALS","Lou Gehrig's disease","motor neuron disease, bulbar"]},"xrefs":{"gard":"5786","icd10":"G12.21","icd9":"335.20","kegg":"05014","mesh":"D000690","mim":"PS105400","ncit":"C34373","ordo":"803","snomedct_us_2025_09_01":"86044005","umls_cui":"C0002736"}},"hpo":{"disease_name":"Amyotrophic lateral sclerosis","orphanet":"803","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040280","hpo_id":"HP:0007354","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0002180","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0003324","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0007373","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000217","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000708","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000712","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000716","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000739","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001257","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001260","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001347","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001618","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0001824","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002015","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002094","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002307","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002380","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0002878","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0003202","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0003394","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0003470","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0003484","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0003487","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0003693","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0007340","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0008955","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0012378","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0012473","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0012531","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0030192","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0030195","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0030196","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0030878","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0031993","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0100543","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001308","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002145","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002313","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002360","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0002463","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0003376","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0004326","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0009027","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0012764","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0033683","orphanet_refs":"orphanet:803"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0025425","orphanet_refs":"orphanet:803"}]},"mondo":{"ancestors":["MONDO:0005559","MONDO:0700096","MONDO:0003182","MONDO:0000001","MONDO:0005071","MONDO:0020128","MONDO:0002545","MONDO:7770006","MONDO:0002602","MONDO:0019056"],"children":["MONDO:0005144","MONDO:0005145","MONDO:0008782","MONDO:0018687"],"curated_content_resource":{"https":["https://search.clinicalgenome.org/kb/conditions/MONDO:0004976"]},"definition":"Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord. [Orphanet:803]","descendants":["MONDO:0007105","MONDO:0018687","MONDO:0021824","MONDO:0005145","MONDO:0005144","MONDO:0013715","MONDO:0014181","MONDO:0012077","MONDO:0014395","MONDO:0014640","MONDO:0013501","MONDO:0859529","MONDO:0013264","MONDO:0030872","MONDO:0011196","MONDO:0014531","MONDO:0012753","MONDO:0008781","MONDO:0011951","MONDO:0008780","MONDO:0012945","MONDO:0017593","MONDO:0027694","MONDO:0011691","MONDO:0013891","MONDO:0014223","MONDO:0007103","MONDO:0030875","MONDO:0008782","MONDO:0010459","MONDO:0011632","MONDO:0011952","MONDO:0014641","MONDO:0957538","MONDO:0011223","MONDO:0010936","MONDO:0012790","MONDO:0030885"],"disease_has_feature":{"hp":["HP:0007354"]},"label":"amyotrophic lateral sclerosis","mondo":"MONDO:0004976","parents":["MONDO:0003182","MONDO:0020128"],"synonym":{"exact":["ALS","amyotrophic lateral sclerosis","Charcot disease","Lou Gehrig disease"]},"xrefs":{"birnlex":["12566"],"doid":["DOID:332"],"gard":["0005786"],"hp":["HP:0007354"],"icd10cm":["G12.21"],"icd11":["foundation:1982355687"],"icd9":["335.20"],"meddra":["10002026"],"medgen":["274"],"mesh":["D000690"],"nando":["1200002"],"ncit":["C34373"],"nord":["57"],"orphanet":["803"],"sctid":["86044005"],"umls":["C0002736"]}},"original_id":"orphanet:803","umls":{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10cm":{"preferred":"G12.21"},"icd9cm":{"non-preferred":"335.20","preferred":"335.20"},"mesh":{"non-preferred":"D000690","preferred":"D000690"},"nci":{"non-preferred":"C34373","preferred":"C34373"},"snomed":{"non-preferred":"86044005","preferred":"86044005"},"umls":"C0002736"}}