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syndrome characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure. [NCIT:P378]","label":"capillary leak syndrome","mondo":"MONDO:0001956","parents":["MONDO:0001574","MONDO:0002254"],"synonym":{"exact":["acute vascular leak syndrome","AVLS","capillary hyperpermeability syndrome","capillary leak syndrome","Clarkson disease","CLS","idiopathic capillary leak syndrome","SCLS","Systemic Capillary Leak Syndrome","systemic capillary leak syndrome"],"related":["capillary leak syndrome with monoclonal gammopathy","periodic systemic capillary leak syndrome"]},"xrefs":{"doid":["DOID:14400"],"efo":["EFO:1001284"],"gard":["0001084"],"icd9":["448.9"],"meddra":["10007196"],"medgen":["137987"],"mesh":["D019559"],"ncit":["C62578"],"orphanet":["188"],"sctid":["87730004"],"umls":["C0343084"]}},"original_id":["orphanet:188","UMLS:C1382398","UMLS:C0343084"],"umls":[{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","nci":{"preferred":"C219992"},"snomed":{"non-preferred":"1608005","preferred":"1608005"},"umls":"C1382398"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","mesh":{"non-preferred":"D019559","preferred":"D019559"},"nci":{"non-preferred":"C62578","preferred":"C62578"},"snomed":{"non-preferred":"87730004","preferred":"87730004"},"umls":"C0343084"}]}