{"_id":"MONDO:0000754","_version":1,"ctd":{"chemical_related_to_disease":[{"cas_registry_number":"85721-33-1","chemical_name":"Ciprofloxacin","direct_evidence":"therapeutic","mesh_chemical_id":"D002939","pubmed":"18371140","source":"CTD"},{"chemical_name":"Drugs, Chinese Herbal","direct_evidence":"therapeutic","mesh_chemical_id":"D004365","pubmed":"15043669","source":"CTD"},{"cas_registry_number":"113-15-5","chemical_name":"Ergotamine","direct_evidence":"marker/mechanism","mesh_chemical_id":"D004878","pubmed":"8197748","source":"CTD"}],"mesh":"D012003"},"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:1285","DOID:5295","DOID:4","DOID:7","DOID:77"],"children":[],"def":"\"An anus disease characterized by is an abnormal connection between the epithelialised surface of the anal canal and the perianal skin.\" [url:http\\://en.wikipedia.org/wiki/Anal_fistula]","descendants":[],"doid":"DOID:0060328","name":"anal fistula","parents":["DOID:1285"],"synonyms":{},"xrefs":{"icd10":"K60.3","mesh":"D012003"}},"hpo":{"disease_name":"Anal fistula","orphanet":"228113","phenotype_related_to_disease":[{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040281","hpo_id":"HP:0005218","orphanet_refs":"orphanet:228113"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0000989","orphanet_refs":"orphanet:228113"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0100658","orphanet_refs":"orphanet:228113"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040282","hpo_id":"HP:0500005","orphanet_refs":"orphanet:228113"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040283","hpo_id":"HP:0001974","orphanet_refs":"orphanet:228113"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0001945","orphanet_refs":"orphanet:228113"},{"biocuration":{"date":"2026-06-23","name":"ORPHA:orphadata"},"evidence":"TAS","hp_freq":"HP:0040284","hpo_id":"HP:0025143","orphanet_refs":"orphanet:228113"}]},"mondo":{"ancestors":["MONDO:1040017","MONDO:0004335","MONDO:0700096","MONDO:0005020","MONDO:0000001","MONDO:0024634","MONDO:7770006","MONDO:0001593"],"definition":"An intestinal disorder characterized by an opening in the anal canal to the perianal skin. In the vast majority of cases there is a history of perianal abscess. [https://orcid.org/0000-0002-0587-4693, NCIT:C60785]","label":"anal fistula","mondo":"MONDO:0000754","parents":["MONDO:0001593","MONDO:1040017"],"synonym":{"exact":["anal fistula","anal fistula (disease)","anorectal fistula"]},"xrefs":{"doid":["DOID:0060328"],"gard":["0020568"],"hp":["HP:0010447"],"icd10cm":["K60.3"],"icd11":["foundation:206903882"],"medgen":["61482"],"mesh":["D012003"],"ncit":["C60785"],"orphanet":["228113"],"sctid":["72779005"],"umls":["C0205929"]}},"original_id":["orphanet:228113","UMLS:C0149889","UMLS:C0205929"],"umls":[{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"preferred":"K60.5"},"icd10am":{"preferred":"K60.5"},"icd10cm":{"preferred":["K60.50","K60.5"]},"nci":{"non-preferred":"C60785","preferred":"C60785"},"snomed":{"non-preferred":"72779005","preferred":["72779005","197153005"]},"umls":"C0149889"},{"_license":"https://www.nlm.nih.gov/research/umls/knowledge_sources/metathesaurus/release/license_agreement.html","icd10":{"preferred":"K60.3"},"icd10am":{"preferred":"K60.3"},"icd10cm":{"non-preferred":"K60.30","preferred":["K60.30","K60.3"]},"icd9cm":{"preferred":"565.1"},"mesh":{"preferred":"D012003"},"snomed":{"non-preferred":["367471000","72779005","155792002","197158001","786878009","54046004","197153005","197156002"],"preferred":["197153005","367471000","786878009","54046004"]},"umls":"C0205929"}]}